Catalog No.
YHK95201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu355-Glu485
Predicted molecular weight
17.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N4X5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1914, AFAP1-like protein 2, Actin filament-associated protein 1-like 2, AFAP1L2, XB130
Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy., PMID:37733919
High XB130 expression in renal cell carcinoma is strongly associated with poor prognosis., PMID:37729738
Proteomics of immune cells from liver tumors reveals immunotherapy targets., PMID:37388918
AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway., PMID:36631800
Adaptor protein XB130 regulates the aggressiveness of cholangiocarcinoma., PMID:34780466
XB130 Plays an Essential Role in Folliculogenesis Through Mediating Interactions Between Microfilament and Microtubule Systems in Thyrocytes., PMID:34652970
Disulfiram Synergizes with SRC Inhibitors to Suppress the Growth of Pancreatic Ductal Adenocarcinoma Cells in Vitro and in Vivo., PMID:34471060
The Clinicopathological Results of Thyroid Cancer With BRAFV600E Mutation in the Young Population of Fukushima., PMID:32827026
XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the proliferation and metastasis of non-small-cell lung cancer cells., PMID:32159887
Knockdown of XB130 restrains cancer stem cell-like phenotype through inhibition of Wnt/β-Catenin signaling in breast cancer., PMID:31219645
The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice., PMID:30667096
Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure., PMID:30521666
Actin Filament-Associated Protein 1-Like 1 Mediates Proliferation and Survival in Non-Small Cell Lung Cancer Cells., PMID:29323101
Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population., PMID:29212154
XB130 enhances invasion and migration of human colorectal cancer cells by promoting epithelial‑mesenchymal transition., PMID:28849225
Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima., PMID:28351223
Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration., PMID:27835612
XB130 is overexpressed in prostate cancer and involved in cell growth and invasion., PMID:27509056
XB130: A novel adaptor protein in cancer signal transduction., PMID:26998266
XB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival., PMID:26446840
Expression of XB130 in human ductal breast cancer., PMID:26191231
XB130 expression in human osteosarcoma: a clinical and experimental study., PMID:26045762
XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells., PMID:25980441
Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk., PMID:25892537
XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis., PMID:24995146
Prognostic significance of XB130 expression in surgically resected pancreatic ductal adenocarcinoma., PMID:24581082
XB130 promotes proliferation and invasion of gastric cancer cells., PMID:24387290
XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells., PMID:23527086
XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt., PMID:22928011
Silencing of XB130 is associated with both the prognosis and chemosensitivity of gastric cancer., PMID:22927913
XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma., PMID:22805860
Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma., PMID:22190283
AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes., PMID:21333378
XB130, a novel adaptor protein, promotes thyroid tumor growth., PMID:21224076
XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway., PMID:19060924
Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells., PMID:18844995
XB130, a novel adaptor protein for signal transduction., PMID:17412687
For research use only. Not for human or drug use.
