Catalog No.
YHK94901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg526-Asn751
Predicted molecular weight
27.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96RP9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Elongation factor G1, GFM, GFM1, EFG1, mEF-G 1, Elongation factor G, mitochondrial, EF-Gmt, EFG, hEFG1, Elongation factor G 1, mitochondrial
Mitochondrial Proteome Reveals Metabolic Tuning by Restricted Insulin Signaling to Promote Longevity in Caenorhabditis elegans., PMID:40136535
Polydatin and Nicotinamide Prevent Iron Accumulation and Lipid Peroxidation in Cellular Models of Mitochondrial Diseases., PMID:40002401
Evaluation of GFM1 mutations pathogenicity through in silico tools, RNA sequencing and mitophagy pahtway in GFM1 knockout cells., PMID:39952508
Detection of Genetic Variations in Children with Tetralogy of Fallot Using Whole Exome Sequencing Technology Integrated Bioinformatics Analysis., PMID:39653367
High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan., PMID:39368088
Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production., PMID:38927630
Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation., PMID:38786005
The first case of combined oxidative phosphorylation deficiency-1 due to a GFM1 mutation in the Serbian population: a case report and literature review., PMID:38204316
Translation Fidelity and Respiration Deficits in CLPP-Deficient Tissues: Mechanistic Insights from Mitochondrial Complexome Profiling., PMID:38139332
The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes., PMID:35954215
Whole exome sequencing identifies a novel compound heterozygous GFM1 variant underlying developmental delay, dystonia, polymicrogyria, and severe intellectual disability in a Pakhtun family., PMID:35703069
UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases., PMID:35581596
Polyamide Microsized Particulate Polyplex Carriers for the 2'-OMethylRNA EFG1 Antisense Oligonucleotide., PMID:35006798
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA., PMID:34943861
Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations., PMID:34919756
Identification of Biomarkers Related to CD8+ T Cell Infiltration With Gene Co-expression Network in Lung Squamous Cell Carcinoma., PMID:33816462
[Analysis of GFM1 gene mutations in a family with combined oxidative phosphorylation deficiency 1]., PMID:33210482
Clinical and molecular findings in a family expressing a novel heterozygous variant of the G elongation factor mitochondrial 1 gene., PMID:33093908
Carbon ion combined with tigecycline inhibits lung cancer cell proliferation by inducing mitochondrial dysfunction., PMID:33065148
A novel composition of two heterozygous GFM1 mutations in a Chinese child with epilepsy and mental retardation., PMID:32776492
Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation., PMID:32737313
Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1., PMID:32602580
Clinical, neuroimaging and biochemical findings in patients and patient fibroblasts expressing ten novel GFM1 mutations., PMID:31680380
EGR1-induced upregulation of lncRNA FOXD2-AS1 promotes the progression of hepatocellular carcinoma via epigenetically silencing DKK1 and activating Wnt/β-catenin signaling pathway., PMID:30929558
The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation., PMID:28680094
Effects of plant density on recombinant hemagglutinin yields in an Agrobacterium-mediated transient gene expression system using Nicotiana benthamiana plants., PMID:28369753
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?, PMID:28361860
Activation of a cryptic splice site in the mitochondrial elongation factor GFM1 causes combined OXPHOS deficiency., PMID:28216230
A tissue factor-cascade-targeted strategy to tumor vasculature: a combination of EGFP-EGF1 conjugation nanoparticles with photodynamic therapy., PMID:27793028
Recombinant epidermal growth factor-like domain-1 from coagulation factor VII functionalized iron oxide nanoparticles for targeted glioma magnetic resonance imaging., PMID:27785017
Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets., PMID:27768122
Generation of a human iPSC line from a patient with a mitochondrial encephalopathy due to mutations in the GFM1 gene., PMID:27345796
[New assessment method in rheumatoid arthritis]., PMID:27311181
Neonatal mitochondrial hepatoencephalopathy caused by novel GFM1 mutations., PMID:26937387
Enhanced Antitumor Activity of EGFP-EGF1-Conjugated Nanoparticles by a Multitargeting Strategy., PMID:26890991
Platelet-rich plasma as treatment for persistent ocular epithelial defects., PMID:25728718
The effect of small molecules on nuclear-encoded translation diseases., PMID:24012549
Toward genotype phenotype correlations in GFM1 mutations., PMID:21986555
Mutation in subdomain G' of mitochondrial elongation factor G1 is associated with combined OXPHOS deficiency in fibroblasts but not in muscle., PMID:21119709
Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu., PMID:17160893
The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1., PMID:16632485
Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency., PMID:15537906
Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution., PMID:11735030
For research use only. Not for human or drug use.
