Catalog No.
YHF42501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile146
Predicted molecular weight
19.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P61326
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAGOH, Protein mago nashi homolog, MAGOHA
PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expression., PMID:40161626
Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway., PMID:40053537
Splicing factor SF3B4 acts as a switch in cancer cell senescence by regulating p21 mRNA stability., PMID:39961431
Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans., PMID:38811212
MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation., PMID:38268030
MAGOH is correlated with poor prognosis and is essential for cell proliferation in lower-grade glioma., PMID:37390121
The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes., PMID:37294214
Serine-rich domain of RNPS1 functions in activation of alternative splicing., PMID:37204171
MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A., PMID:36497117
Multifaceted roles of MAGOH Proteins., PMID:36396768
Exon-dependent transcriptional adaptation by exon-junction complex proteins Y14/RNP-4 and MAGOH/MAG-1 in Caenorhabditis elegans., PMID:36315586
Diverse Roles of the Exon Junction Complex Factors in the Cell Cycle, Cancer, and Neurodevelopmental Disorders-Potential for Therapeutic Targeting., PMID:36142288
Mutations equivalent to Drosophila mago nashi mutants imply reduction of Magoh protein incorporation into exon junction complex., PMID:35430764
The Physiological Roles of the Exon Junction Complex in Development and Diseases., PMID:35406756
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis., PMID:35403545
The Exon Junction Complex Core Represses Cancer-Specific Mature mRNA Re-splicing: A Potential Key Role in Terminating Splicing., PMID:34204574
MAGOH/MAGOHB Inhibits the Tumorigenesis of Gastric Cancer via Inactivation of b-RAF/MEK/ERK Signaling., PMID:33328743
The EJC component Magoh in non-vertebrate chordates., PMID:32632492
Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets., PMID:32502192
Epigenome-Wide Tobacco-Related Methylation Signature Identification and Their Multilevel Regulatory Network Inference for Lung Adenocarcinoma., PMID:32420331
Development of Magoh protein-overexpressing HEK cells for optimized therapeutic protein production., PMID:32249976
Development and evaluation of extruded ready-to-eat snack from optimized rice, kersting's groundnut and lemon pomace composite flours., PMID:31975711
Dosage-dependent requirements of Magoh for cortical interneuron generation and survival., PMID:31857347
RNA-sequence-based microRNA expression signature in breast cancer: tumor-suppressive miR-101-5p regulates molecular pathogenesis., PMID:31755218
The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization., PMID:30826064
Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing., PMID:30388411
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer., PMID:29955178
Roles of the exon junction complex components in the central nervous system: a mini review., PMID:29791316
C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization., PMID:29330450
Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression., PMID:28263985
Molecular finds of pressure ulcer: A bioinformatics approach in pressure ulcer., PMID:28188042
Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex., PMID:27780844
Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly., PMID:27618312
The Exon Junction Complex Controls the Efficient and Faithful Splicing of a Subset of Transcripts Involved in Mitotic Cell-Cycle Progression., PMID:27490541
The exon junction complex in neural development and neurodevelopmental disease., PMID:27071691
MLL2 is essential for porcine embryo development in vitro., PMID:27059328
A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors., PMID:26094033
A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay., PMID:25616068
Transcriptome-wide modulation of splicing by the exon junction complex., PMID:25476502
Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh., PMID:25349214
Overexpression of MLN51 triggers P-body disassembly and formation of a new type of RNA granules., PMID:25205763
Generation of a Magoh conditional allele in mice., PMID:24771530
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity., PMID:23983263
Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., PMID:23970407
RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells., PMID:23949737
Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay., PMID:23917022
Diffusion and binding analyzed with combined point FRAP and FCS., PMID:23847177
Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein., PMID:23817415
Btf and TRAP150 have distinct roles in regulating subcellular mRNA distribution., PMID:23778535
Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway., PMID:23427269
For research use only. Not for human or drug use.
