Catalog No.
YHG94301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys396-Pro579
Predicted molecular weight
23.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14995
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Rev-erb alpha-related receptor, V-erbA-related protein 1-related, Rev-erb-beta, NR1D2, Orphan nuclear hormone receptor BD73, RVR, Nuclear receptor subfamily 1 group D member 2, EAR-1R
REV-ERBβ Binding Pocket Dynamics With Implications for Rational Design of Small Molecule Modulators., PMID:40418107
The Circadian Clock Component REV-ERB Is an Analgesic Target for Cancer-Induced Tactile Pain Hypersensitivity., PMID:40268481
Core Molecular Clock Factors Regulate Osteosarcoma Stem Cell Survival and Behavior via CSC/EMT Pathways and Lipid Droplet Biogenesis., PMID:40214471
Development of radioligand binding assays for REV-ERBα and REV-ERBβ., PMID:40189177
Identification of key immune genes of drug-induced liver injury induced by tolvaptan based on bioinformatics., PMID:40178603
Galactose-Induced Cataracts in Rats: A Machine Learning Analysis., PMID:40027191
Sex-dependent association of central circadian clock gene polymorphisms with clinical risk markers for noncommunicable diseases in the young population., PMID:39894351
Maternal high-fat diet alters the transcriptional rhythm in white adipose tissue of adult offspring., PMID:39826765
Impact of Long-Term Cannabidiol (CBD) Treatment on Mouse Kidney Transcriptome., PMID:39766907
The role of circadian rhythm proteins Rev-Erbα and β in the development of neuronal injury after traumatic brain injury., PMID:39734357
Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways., PMID:39516282
Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms., PMID:39485282
A majority of circadian clock genes are expressed in estrogen receptor and progesterone receptor status-dependent manner in breast cancer., PMID:39193850
Timing of acute cold exposure determines UCP1 and FGF21 expression - Possible interactions between the thermal environment, thermoregulatory responses, and peripheral clocks., PMID:39142264
Mesenchymal Stem Cells Alleviate Mouse Sepsis-Induced Cardiomyopathy by Inhibiting the NR1D2/LCN2 Pathway., PMID:39115719
Fibroblasts as an in vitro model of circadian genetic and genomic studies., PMID:38960898
Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors., PMID:38529771
Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response., PMID:38331257
Functional Characterization of Circadian Nuclear Receptors REV-ERBα and REV-ERBβ in Human Osteosarcoma Cell Cultures., PMID:38255844
Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology., PMID:38142970
Identification of genomic regions, genetic variants and gene networks regulating candidate genes for lipid metabolism in pig muscle., PMID:38064855
Identification of ferroptosis-related genes in type 2 diabetes mellitus based on machine learning., PMID:37904700
Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression., PMID:37844410
Genomic Insights Into Statin Therapy: Differential Expression Analysis of Key Genes., PMID:37741602
Disruptions of Circadian Genes in Cutaneous Melanoma-An In Silico Analysis of Transcriptome Databases., PMID:37373286
Human nuclear hormone receptor activity contributes to malaria parasite liver stage development., PMID:37172592
Evaluation of perinatal exposure of glyphosate and its mixture with 2,4-D and dicamba οn liver redox status in Wistar rats., PMID:37062480
A time- and space-resolved nuclear receptor atlas in mouse liver., PMID:36988391
Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep-wake rhythm disorder., PMID:36897197
Integrated bioinformatics, network pharmacology, and artificial intelligence to predict the mechanism of celastrol against muscle atrophy caused by colorectal cancer., PMID:36419834
Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia., PMID:36284122
Temperature synchronisation of circadian rhythms in primary human airway epithelial cells from children., PMID:36198442
Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging., PMID:36077427
Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity., PMID:35912794
Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium., PMID:35780861
Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function., PMID:35036997
LINC01224 facilitates the proliferation and inhibits the radiosensitivity of melanoma cells through the miR-193a-5p/NR1D2 axis., PMID:34783160
Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer., PMID:34440171
Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice., PMID:34191629
Molecular Dynamics of Cobalt Protoporphyrin Antagonism of the Cancer Suppressor REV-ERBβ., PMID:34071361
Transcriptional mediators of treatment resistance in lethal prostate cancer., PMID:33664492
Ferric heme as a CO/NO sensor in the nuclear receptor Rev-Erbß by coupling gas binding to electron transfer., PMID:33436410
A Sextuple Knockout Cell Line System to Study the Differential Roles of CRY, PER, and NR1D in the Transcription-Translation Feedback Loop of the Circadian Clock., PMID:33381013
A seven-nuclear receptor-based prognostic signature in breast cancer., PMID:33210236
Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability., PMID:33096076
Ammonia exposure causes lung injuries and disturbs pulmonary circadian clock gene network in a pig study., PMID:32827960
Determination of genetic changes of Rev-erb beta and Rev-erb alpha genes in Type 2 diabetes mellitus by next-generation sequencing., PMID:32798635
Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection., PMID:32777979
The transcriptional repressor REV-ERB as a novel target for disease., PMID:32738989
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types., PMID:32732282
For research use only. Not for human or drug use.
