Catalog No.
YHK93901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg1117-His1181
Predicted molecular weight
20.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WXX7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0442, AUTS2, Autism susceptibility gene 2 protein
Essential roles of DCAF7/WDR68 in mouse embryonic development., PMID:40462101
Parent-of-origin regulation by maternal auts2 shapes neurodevelopment and behavior in fish., PMID:40346605
Further Delineation of the AUTS2 HX Repeat Domain-Related Phenotype., PMID:40317680
The microcephaly-associated transcriptional regulator AUTS2 cooperates with Polycomb complex PRC2 to produce upper-layer neurons in mice., PMID:39815005
Establishment of a non-integrated iPS cell line (SDQLCHi072-A) from a patient suffered from AUTS2 syndrome., PMID:39276529
Loss of Zmiz1 in mice leads to impaired cortical development and autistic-like behaviors., PMID:39211117
AUTS2 disruption causes neuronal differentiation defects in human cerebral organoids through hyperactivation of the WNT/β-catenin pathway., PMID:39174599
De Novo Pathogenic Variant in FBRSL1, Non OMIM Gene Paralogue AUTS2, Causes a Novel Recognizable Syndromic Manifestation with Intellectual Disability; An Additional Patient and Review of the Literature., PMID:39062605
Fbrsl1 is required for heart development in Xenopus laevis and de novo variants in FBRSL1 can cause human heart defects., PMID:38501224
Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells., PMID:38495105
Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets., PMID:38480935
Transcriptional Landscape of CUT-Class Homeobox Genes in Blastic Plasmacytoid Dendritic Cell Neoplasm., PMID:38474011
Construction of a molecular inflammatory predictive model with histone modification-related genes and identification of CAMK2D as a potential response signature to infliximab in ulcerative colitis., PMID:38274809
Unraveling the Genetic Basis of Feed Efficiency in Cattle through Integrated DNA Methylation and CattleGTEx Analysis., PMID:38136943
TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function., PMID:38062027
Genome-wide association analysis reveals the associations of NPHP4, TYW1-AUTS2 and SEMA6D for Behçet's disease and HLA-B*46:01 for its intestinal involvement., PMID:37977914
Establishment of human induced pluripotent stem cell line (SDQLCHi060-A) from a patient with AUTS2 syndrome carrying a heterozygous mutation in AUTS2 gene., PMID:37948839
Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin-lineage cells, generates a specific suite of brain, behavioral, and molecular pathologies., PMID:37816306
Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction., PMID:37802044
CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression., PMID:37679762
Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin -lineage cells, generates a specific suite of brain, behavioral and molecular pathologies., PMID:37205596
Structural polymorphism driven by a register shift in a CGAG-rich region found in the promoter of the neurodevelopmental regulator AUTS2 gene., PMID:36864756
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus., PMID:36803626
Activity-Dependent Differential Regulation of Auts2 Isoforms In Vitro and In Vivo., PMID:36754912
Auts2 regulated autism-like behavior, glucose metabolism and oxidative stress in mice., PMID:36525998
Novel Genes Involved in Hypertrophic Cardiomyopathy: Data of Transcriptome and Methylome Profiling., PMID:36499607
Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort., PMID:36308435
Genomic Predictors of Brisk Walking Are Associated with Elite Sprinter Status., PMID:36292594
Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma., PMID:36273157
AUTS2 Controls Neuronal Lineage Choice Through a Novel PRC1-Independent Complex and BMP Inhibition., PMID:36258139
auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication., PMID:36078102
Two variants of AUTS2 gene are associated with high lean meat percentage in Pekin ducks., PMID:36067863
Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology., PMID:36002036
PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120., PMID:35985167
Cerebral organoids containing an AUTS2 missense variant model microcephaly., PMID:35802027
Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile., PMID:35737155
FMRP-dependent production of large dosage-sensitive proteins is highly conserved., PMID:35731217
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors., PMID:35685361
Highly diverse phenotypes of mucopolysaccharidosis type IIIB sibling patients: effects of an additional mutation in the AUTS2 gene., PMID:35525889
AUTS2 Syndrome: Molecular Mechanisms and Model Systems., PMID:35431798
[Whole-transcriptome sequencing analysis of placental differential miRNA expression profile in Down syndrome]., PMID:35426807
ExceS-A: an exon-centric split aligner., PMID:35254744
Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms., PMID:35235353
Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C., PMID:35027503
AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders., PMID:35011572
Comparing a Novel Malformation Syndrome Caused by Pathogenic Variants in FBRSL1 to AUTS2 Syndrome., PMID:34805182
NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain., PMID:34637754
Attention Deficit Hyperactivity and Autism Spectrum Disorders as the Core Symptoms of AUTS2 Syndrome: Description of Five New Patients and Update of the Frequency of Manifestations and Genotype-Phenotype Correlation., PMID:34573342
High Behavioral Variability Mediated by Altered Neuronal Excitability in auts2 Mutant Zebrafish., PMID:34544758
Clinicopathological and molecular characterizations of pulmonary NUT midline carcinoma., PMID:34409758
For research use only. Not for human or drug use.
