Catalog No.
YHK93801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His108-Tyr159
Predicted molecular weight
18.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6RW13
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATRAP, Type-1 angiotensin II receptor-associated protein, AGTRAP, AT1 receptor-associated protein
Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system., PMID:40442063
The Beneficial Effect of the SGLT2 Inhibitor Dapagliflozin in Alleviating Acute Myocardial Infarction-Induced Cardiomyocyte Injury by Increasing the Sirtuin Family SIRT1/SIRT3 and Cascade Signaling., PMID:39126109
Microglial AT1R Conditional Knockout Ameliorates Hypoperfusive Cognitive Impairment by Reducing Microglial Inflammatory Responses., PMID:38484837
Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice., PMID:38415902
miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap., PMID:37981211
A whole exome sequencing study to identify rare variants in multiplex families with alcohol use disorder., PMID:37915799
Enhancement of angiotensin II type 1 receptor-associated protein in the paraventricular nucleus suppresses angiotensin II-dependent hypertension., PMID:37884662
Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity., PMID:37856903
Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury., PMID:36803446
Formaldehyde causes an increase in blood pressure by activating ACE/AT1R axis., PMID:36706861
Distinct Mechanisms of β-Arrestin-Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality., PMID:36440576
Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization., PMID:36253401
Pan-cancer analysis of the angiotensin II receptor-associated protein as a prognostic and immunological gene predicting immunotherapy responses in pan-cancer., PMID:36060798
Modulation of blood pressure regulatory genes in the Agtrap-Plod1 locus associated with a deletion in Clcn6., PMID:35927940
Age-associated changes in gene expression in the anterior pituitary glands of female Japanese black cattle., PMID:35838775
Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death., PMID:35758026
Focal facial dermal dysplasias type III: Two families with Setleis syndrome in China., PMID:35713327
FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling., PMID:35671117
Fraxinol attenuates LPS-induced acute lung injury by equilibrating ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas and inhibiting NLRP3., PMID:35588103
Lay A TRAP for myeloid cell response in diabetic kidney disease., PMID:35461612
USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling., PMID:35414770
Deficiency of the kidney tubular angiotensin II type1 receptor-associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization., PMID:35240129
Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1 Receptor., PMID:35132870
Construction and Comprehensive Analysis of a Stratification System Based on AGTRAP in Patients with Hepatocellular Carcinoma., PMID:34840632
ATRAP, a receptor-interacting modulator of kidney physiology, as a novel player in blood pressure and beyond., PMID:34642449
AGTRAP Is a Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular Carcinoma., PMID:34595113
S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD., PMID:33753727
LncRNA ARAP1-AS2 promotes high glucose-induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1., PMID:32969198
β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19., PMID:32412788
Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix., PMID:32204550
The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019., PMID:32112267
Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells., PMID:31873081
Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line., PMID:31719572
Ablation of Immunoproteasome β5i Subunit Suppresses Hypertensive Retinopathy by Blocking ATRAP Degradation in Mice., PMID:31636038
Transcripto-based network analysis reveals a model of gene activation in tongue squamous cell carcinomas., PMID:31589000
Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury., PMID:31511362
AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, blocks inflammatory mediators, and upregulates antioxidant enzymes and bone formation markers., PMID:31473996
Angiotensin receptor expression revealed by reporter mice and beneficial effects of AT2R agonist in retinal cells., PMID:31449794
Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension., PMID:30977419
Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension., PMID:30830950
Host-Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2-Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism., PMID:30681344
Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population., PMID:30630996
LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension., PMID:30547791
miR-370 promotes high glucose-induced podocyte injuries by inhibiting angiotensin II type 1 receptor-associated protein., PMID:30095204
Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans., PMID:30080444
Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85., PMID:29589748
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue., PMID:29434287
Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile., PMID:29407599
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database., PMID:29257295
Effect of prehypertensive losartan therapy on AT1R and ATRAP methylation of adipose tissue in the later life of high‑fat‑fed spontaneously hypertensive rats., PMID:29257219
For research use only. Not for human or drug use.
