Catalog No.
YHF85101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser278
Predicted molecular weight
34.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01082
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-II spectrin, SPTB2, Spectrin, non-erythroid beta chain 1, Spectrin beta chain, non-erythrocytic 1, SPTBN1, Fodrin beta chain
Promotion of Cx26 mutants located in TM4 region for membrane translocation successfully rescued hearing loss., PMID:40365300
Proteomic signatures of retinal pigment epithelium-derived exosomes in myopic and non-myopic tree shrew eyes., PMID:40330779
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression., PMID:40301554
Genome Sequencing of Idiopathic Speech Delay., PMID:40225914
A Novel tRF, HCETSR, Derived From tRNA-Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1-catenin Complex Axis., PMID:39921434
Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice., PMID:39848964
Molecules That Have Rarely Been Studied in Lymphatic Endothelial Cells., PMID:39596293
Heterozygous loss-of-function variants in SPTAN1 cause a novel early childhood onset distal myopathy with chronic neurogenic features., PMID:39371122
Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading., PMID:39276238
Proteomic profiling of cerebrospinal fluid reveals TKT as a potential biomarker for medulloblastoma., PMID:39251709
Aldehydes alter TGF-β signaling and induce obesity and cancer., PMID:39217614
Diverse clinical presentation of SPTBN1 variants: Complex versus primary attention-deficit/hyperactivity disorder., PMID:39162370
Cardiomyocyte βII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function., PMID:38832923
GM1 Ameliorates Neuronal Injury in Rats after Cerebral Ischemia and Reperfusion: Potential Contribution of Effects on SPTBN1-mediated Signaling., PMID:38810691
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype., PMID:38780883
Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1., PMID:38683846
Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction., PMID:38441922
Analysis of immunoinfiltration and EndoMT based on TGF-β signaling pathway-related genes in acute myocardial infarction., PMID:38431730
SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma., PMID:38069214
Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression., PMID:37921259
Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, autophagy, and YB-1 independent manner., PMID:37910521
METTL3-mediated m6 A modification of circPRKAR1B promotes Crohn's colitis by inducing pyroptosis via autophagy inhibition., PMID:37679886
Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, Autophagy, and YB-1 independent manner., PMID:37546823
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity., PMID:37404133
RNA Sequencing Reveals Novel Oncogenic Fusions and Depicts Detailed Fusion Transcripts of FN1-FGFR1 in Phosphaturic Mesenchymal Tumors., PMID:37391169
Revealing the Organ-Specific Expression of SPTBN1 using Single-Cell RNA Sequencing Analysis., PMID:37333135
iASPP regulates neurite development by interacting with Spectrin proteins., PMID:37284462
Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis., PMID:37013511
Spectrins: molecular organizers and targets of neurological disorders., PMID:36697767
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome., PMID:36604605
Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development., PMID:36576422
SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner., PMID:36527113
SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2., PMID:36444616
RNA Modification-Related Genetic Variants in Genomic Loci Associated with Bone Mineral Density and Fracture., PMID:36292776
Gene Expression Characteristics of Tumor and Adjacent Non-Tumor Tissues of Pancreatic Ductal Adenocarcinoma (PDAC) In-Silico., PMID:35891953
Unclassified white matter disorders: A diagnostic journey requiring close collaboration between clinical and laboratory services., PMID:35803560
SPTBN5, Encoding the βV-Spectrin Protein, Leads to a Syndrome of Intellectual Disability, Developmental Delay, and Seizures., PMID:35782384
Genome-Wide Association Study of Potential Meat Quality Trait Loci in Ducks., PMID:35741748
Paracetamol perturbs neuronal arborization and disrupts the cytoskeletal proteins SPTBN1 and TUBB3 in both human and chicken in vitro models., PMID:35714712
Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas., PMID:35641855
Impaired reciprocal regulation between SIRT6 and TGF-β signaling in fatty liver., PMID:35506565
Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse., PMID:35245370
CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome., PMID:35133174
Prognostic implications of N6-methyladenosine RNA regulators in breast cancer., PMID:35075167
β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development., PMID:34910547
β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia., PMID:34799994
Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development., PMID:34737104
Identification of a Novel Mutation of β-Spectrin in Hereditary Spherocytosis Using Whole Exome Sequencing., PMID:34681667
[Gene transcriptome analysis of nasal epithelial cells in chronic rhinosinusitis with nasal polyps]., PMID:34666467
Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes., PMID:34638643
For research use only. Not for human or drug use.
