Catalog No.
YHA18101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser174-Gly250
Predicted molecular weight
22.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00716
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E2F-3, KIAA0075, Transcription factor E2F3, E2F3
ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration., PMID:40467575
The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response., PMID:40455982
Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells., PMID:40447783
SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma., PMID:40402518
Centromere Protein F Is a Potential Prognostic Biomarker and Target for Cutaneous Melanoma., PMID:40299364
TACC3 enhances glycolysis in bladder cancer cells through inducing acetylation of c-Myc., PMID:40246827
The role of miR-150-5p/E2F3/survivin axis in the pathogenesis of plasmablastic lymphoma and its therapeutic potential., PMID:40203244
The evolution and functional characterization of transcription factors E2Fs in lamprey, Lethenteron reissneri., PMID:40031963
[The expression of YTHDF2 in cervical lesions and its relationship with prognosis based on bioinformatics]., PMID:39965835
Exploring the mechanism and drug candidates of alveolar echinococcosis affecting liver fibrosis through analysis of existing microarray data., PMID:39863141
Deciphering the prognostic landscape of triple-negative breast cancer: A focus on immune-related hub genes and therapeutic implications., PMID:39587411
ADAR1 enhances tumor proliferation and radioresistance in non-small cell lung cancer by interacting with Rad18., PMID:39570561
E2F3a activates Gadd45b gene expression through PPARα-mediated transcriptional regulation in hepatic cells., PMID:39537030
Comprehensive cataloging of miR-363 as a therapeutic & non-invasive biomarker of prostate cancer., PMID:39513205
E2F3-dependent activation of FAM111B restricts mouse cytomegalovirus replication in primate cells., PMID:39494906
Study of the Role of E2F1 and TMEM132A in Prostate Cancer Development., PMID:39473405
Anti-liver cancer therapeutic targets and safety of usenamine A in experimental liver cancer., PMID:39360781
BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer., PMID:39209080
The role of palbociclib on the alterations in CDKN2, CCNE1, E2F3, MDM2 expressions as target genes of miR-141., PMID:39116089
Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis., PMID:39045407
Durable Objective Response to Lurbinectedin in Small Cell Bladder Cancer with TP53 Mutation: A Molecular-Directed Strategy., PMID:38920737
MiR-199a-5p Deficiency Promotes Artery Restenosis in Peripheral Artery Disease by Regulating ASMCs Function via Targeting HIF-1α and E2F3., PMID:38910413
Dexamethasone-tamoxifen combination exerts synergistic therapeutic effects in tamoxifen-resistance breast cancer cells., PMID:38864530
miR-449a: A Promising Biomarker and Therapeutic Target in Cancer and Other Diseases., PMID:38809350
PA28γ coordinates the cross-talk between cancer-associated fibroblasts and tumor cells to promote OSCC progression via HDAC1/E2F3/IGF2 signaling., PMID:38768680
A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family., PMID:38570112
FXR/Menin-mediated epigenetic regulation of E2F3 expression controls β-cell proliferation and is increased in islets from diabetic GK rats after RYGB., PMID:38531483
Withaferin A alters the expression of microRNAs 146a-5p and 34a-5p and associated hub genes in MDA-MB-231 cells., PMID:38525814
Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis., PMID:38458026
FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3., PMID:38380957
E2F3/5/8 serve as potential prognostic biomarkers and new therapeutic direction for human bladder cancer., PMID:38215110
Transcription factor E2F3 activates CDC25B to regulate DNA damage and promote mitoxantrone resistance in stomach adenocarcinoma., PMID:38194158
Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network., PMID:38064496
MiR-210-3p enhances intermittent hypoxia-induced tumor progression via inhibition of E2F3., PMID:37775619
E2F3/CDCA2 reduces radiosensitivity in gastric adenocarcinoma by activating PI3K/AKT pathway., PMID:37750838
E2F3 renders an immunosuppressive tumor microenvironment in nasopharyngeal carcinoma: Involvements of the transcription activation of PRC1 and BIRC5., PMID:37647439
Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4+ T cells., PMID:37559728
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses., PMID:37552601
E2F3 induces DNA damage repair, stem-like properties and therapy resistance in breast cancer., PMID:37499929
E2F3 accelerates the stemness of colon cancer cells by activating the STAT3 pathway., PMID:37456248
CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism., PMID:37395281
Small RNA Sequencing Analysis of STZ-Injured Pancreas Reveals Novel MicroRNA and Transfer RNA-Derived RNA with Biomarker Potential for Diabetes Mellitus., PMID:37373469
Circ_001422 aggravates osteosarcoma progression through targeting miR-497-5p/E2F3 axis., PMID:37287369
Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway., PMID:37253635
BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing., PMID:37248466
Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation., PMID:37187020
The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F., PMID:37141667
HOOK1 Inhibits the Progression of Renal Cell Carcinoma via TGF-β and TNFSF13B/VEGF-A Axis., PMID:37085921
Long noncoding RNA POU6F2-AS2 contributes to the aggressiveness of nonsmall-cell lung cancer via microRNA-125b-5p-mediated E2F3 upregulation., PMID:37053020
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells., PMID:36982482
For research use only. Not for human or drug use.
