Catalog No.
YHK93601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr773-Pro929
Predicted molecular weight
20.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BX66
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAP, KIAA0894, c-Cbl-associated protein, SH3 domain protein 5, Sorbin and SH3 domain-containing protein 1, SH3P12, SH3D5, KIAA1296, SORBS1, Ponsin
Identification of Selected Genes Associated With the Prediction of Prognosis in Bladder Cancer., PMID:40370233
Elucidating the roles of SOD3 correlated genes and reactive oxygen species in rare human diseases using a bioinformatic-ontology approach., PMID:39480826
KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle., PMID:39250818
Genome-wide mapping of the binding sites of myocyte enhancer factor 2A in chicken primary myoblasts., PMID:39094502
circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA., PMID:38915053
Stereotactic body radiation therapy suppresses myeloid-derived suppressor cells by regulating miR-21/Sorbin and SH3 Domain-containing Protein 1 axis., PMID:38874389
SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization., PMID:38451194
The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish., PMID:38414014
Examining the molecular mechanisms of topiramate in alleviating insulin resistance: A study on C2C12 myocytes and 3T3L-1 adipocytes., PMID:38308786
Tirzepatide prevents neurodegeneration through multiple molecular pathways., PMID:38287296
Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus., PMID:38212723
DOCK3 regulates normal skeletal muscle regeneration and glucose metabolism., PMID:37742307
Integrated Network Analysis to Determine CNN1, MYL9, TAGLN, and SORBS1 as Potential Key Genes Associated with Prostate Cancer., PMID:37436378
Distinct subtypes of endometriosis identified based on stromal-immune microenvironment and gene expression: implications for hormone therapy., PMID:37426659
MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1., PMID:37164919
Comprehensive analysis of circular RNAs in porcine small intestine epithelial cells associated with susceptibility to Escherichia coli F4ac diarrhea., PMID:37085748
DOCK3 regulates normal skeletal muscle regeneration and glucose metabolism., PMID:36865261
Down-regulation and clinical significance of Sorbin and SH3 domain-containing protein 1 in bladder cancer tissues., PMID:36854874
CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells., PMID:36834818
Suicide-Related Single Nucleotide Polymorphisms, rs4918918 and rs10903034: Association with Dementia in Older Adults., PMID:36421848
Insulin receptor substrate 1(IRS1) is related with lymph node metastases and prognosis in esophageal squamous cell carcinoma., PMID:35688292
Complementary omics strategies to dissect p53 signaling networks under nutrient stress., PMID:35635656
The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome., PMID:35217034
MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway., PMID:35196185
miR-223-3p carried by cancer-associated fibroblast microvesicles targets SORBS1 to modulate the progression of gastric cancer., PMID:35193596
A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population., PMID:35107206
[Bioinformatics-based identification of the key genes associated with prostate cancer]., PMID:34914287
Prediction of potential prognostic biomarkers in metastatic prostate cancer based on a circular RNA-mediated competing endogenous RNA regulatory network., PMID:34860853
Long Non-coding RNAs LOC100126784 and POM121L9P Derived From Bone Marrow Mesenchymal Stem Cells Enhance Osteogenic Differentiation via the miR-503-5p/SORBS1 Axis., PMID:34746123
Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis., PMID:34409913
Differential expression and alternative splicing of transcripts in orbital adipose/connective tissue of thyroid-associated ophthalmopathy., PMID:34078122
The Role of Glycosyltransferases in Colorectal Cancer., PMID:34070747
Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study., PMID:33813136
Regulatory Master Genes Identification and Drug Repositioning by Integrative mRNA-miRNA Network Analysis for Acute Type A Aortic Dissection., PMID:33551796
Construction of an immune-related gene signature for prediction of prognosis in patients with cervical cancer., PMID:32799114
The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway., PMID:32738595
Myasthenia Gravis: From the Viewpoint of Pathogenicity Focusing on Acetylcholine Receptor Clustering, Trans-Synaptic Homeostasis and Synaptic Stability., PMID:32547365
SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines., PMID:32319594
Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1., PMID:31937552
Towards the early detection of ductal carcinoma (a common type of breast cancer) using biomarkers linked to the PPAR(γ) signaling pathway., PMID:31902979
MiR-142-5p Acts as a Significant Regulator Through Promoting Proliferation, Invasion, and Migration in Breast Cancer Modulated by Targeting SORBS1., PMID:31789129
Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators., PMID:31461342
Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats., PMID:31338039
Homocysteine induced oxidative stress in human umbilical vein endothelial cells via regulating methylation of SORBS1., PMID:30402861
Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential., PMID:30114595
Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study., PMID:30002559
The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus., PMID:29631267
Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons., PMID:29567830
Copy Number Variants Are Enriched in Individuals With Early-Onset Obesity and Highlight Novel Pathogenic Pathways., PMID:28605459
A case of a novel mutation in HNF1β-related maturity-onset diabetes of the young type 5 with diabetic kidney disease complication in a Chinese family., PMID:28502589
For research use only. Not for human or drug use.
