Catalog No.
YHD57601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg51-Glu173
Predicted molecular weight
15.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23434
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GCSH, Glycine cleavage system H protein, mitochondrial, Lipoic acid-containing protein
Copper's new role in cancer: how cuproptosis-related genes could revolutionize glioma treatment., PMID:40355831
Co-Colorectal cancer stem cells employ the FADS1/DDA axis to evade NK cell-mediated immunosuppression after co-cultured with NK cells under hypoxia., PMID:39488917
Case report: Unveiling genetic and phenotypic variability in Nonketotic hyperglycinemia: an atypical early onset case associated with a novel GLRX5 variant., PMID:39323869
Identification and validation of a novel cuproptosis signature for stratifying different prognostic, immune, metabolic, and therapeutic landscapes in pancreatic adenocarcinoma., PMID:38497885
Cuproptosis-related genes score and its hub gene GCSH: A novel predictor for cholangiocarcinomas prognosis based on RNA seq and experimental analyses., PMID:38370386
Integrated analysis reveals a potential cuproptosis-related ceRNA axis SNHG17/miR-29a-3p/GCSH in prostate adenocarcinoma., PMID:38027603
Comprehensive Analysis of the Relationship between Cuproptosis-Related Gene GCSH and Prognosis, Tumor Microenvironment Infiltration, and Therapy Response in Endometrial Cancer., PMID:37827132
Bioinformatics analysis of copper death gene in diabetic immune infiltration., PMID:37773841
Structure relationship of non-covalent interactions between lotus seedpod oligomeric procyanidins and glycated casein hydrolysate during digestion., PMID:37580964
FDX1 regulates cellular protein lipoylation through direct binding to LIAS., PMID:37453661
Novel Cuproptosis-Related Gene Signature for Precise Identification of High-Risk Populations in Low-Grade Gliomas., PMID:36814682
System analysis based on the cuproptosis-related genes identifies LIPT1 as a novel therapy target for liver hepatocellular carcinoma., PMID:36195876
Pathogenic variants in GCSH encoding the moonlighting H-protein cause combined nonketotic hyperglycinemia and lipoate deficiency., PMID:36190515
Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton., PMID:33947373
Biallelic start loss variant, c.1A > G in GCSH is associated with variant nonketotic hyperglycinemia., PMID:33890291
Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System., PMID:33569080
Glutathione ethyl ester supplementation prevents airway hyper-responsiveness in mice., PMID:33313264
Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats., PMID:33057941
Intrahepatocellular crystal storing mimicking a clinical liver disease during monoclonal gammopathy: report of a case and review of the literature., PMID:32041459
All-trans-retinal induces autophagic cell death via oxidative stress and the endoplasmic reticulum stress pathway in human retinal pigment epithelial cells., PMID:31931077
The plasma peptides of breast versus ovarian cancer., PMID:31889940
Identification of gene co-expression modules and hub genes associated with lymph node metastasis of papillary thyroid cancer., PMID:31332712
GCSH antisense regulation determines breast cancer cells' viability., PMID:30337557
Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes., PMID:29232014
TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling., PMID:29106517
Genetic association of the glycine cleavage system genes and myelomeningocele., PMID:27620832
All-trans-retinal dimer formation alleviates the cytotoxicity of all-trans-retinal in human retinal pigment epithelial cells., PMID:27751755
Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans., PMID:27481395
Mutation analysis of GLDC, AMT and GCSH in cataract captive-bred vervet monkeys (Chlorocebus aethiops)., PMID:27325422
Alpha-lipoic acid reduces methylmercury-induced neuronal injury in rat cerebral cortex via antioxidation pathways., PMID:27298056
Analysis of Sensitive CO2 Pathways and Genes Related to Carbon Uptake and Accumulation in Chlamydomonas reinhardtii through Genomic Scale Modeling and Experimental Validation., PMID:26904035
Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births., PMID:26824641
Tea Polyphenols Protect Against Methylmercury-Induced Cell Injury in Rat Primary Cultured Astrocytes, Involvement of Oxidative Stress and Glutamate Uptake/Metabolism Disorders., PMID:25952541
Involvement of endoplasmic reticulum stress in all-trans-retinal-induced retinal pigment epithelium degeneration., PMID:25331497
Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy., PMID:25231368
Epigallocatechin gallate supplementation protects against renal injury induced by fluoride intoxication in rats: Role of Nrf2/HO-1 signaling., PMID:28962222
Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5., PMID:24334290
[Effect of electroacupuncture on expression of gamma-glutamylcysteine synthetase protein and mRNA in cerebral cortex in rats with focal cerebral ischemia-reperfusion]., PMID:22574565
Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans., PMID:22171071
Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancer., PMID:21706489
An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells., PMID:19958826
Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress., PMID:18038766
Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae., PMID:17942904
Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity., PMID:17573345
Transcription factor Nrf2 activation by deltamethrin in PC12 cells: Involvement of ROS., PMID:17540521
Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia., PMID:17361008
[Time course of gene expression of gamma-glutamylcysteine synthetase subunit and Nrf2 in brain tissues of rats exposed by deltamethrin]., PMID:16758951
[Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue]., PMID:16737586
Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia., PMID:16450403
Treatment from birth of nonketotic hyperglycinemia due to a novel GLDC mutation., PMID:16404748
For research use only. Not for human or drug use.
