Catalog No.
YHA84201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser10-Glu276
Predicted molecular weight
33.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60239
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAB, SH3 domain-binding protein that preferentially associates with BTK, SH3 domain-binding protein 5, SH3BP5, SH3BP-5
The Causal Relationship Between Gut Microbiomes, Inflammatory Mediators, and Traumatic Brain Injury in Europeans: Evidence from Genetic Correlation and Functional Mapping Annotation Analyses., PMID:40149729
Identification and validation of palmitoylation-related biomarkers in gestational diabetes mellitus., PMID:40055514
Sodium-Glucose Cotransporter 2 (SGLT2) as a Potential Biomarker and Target in Papillary Renal Cell Carcinoma., PMID:40020263
The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice., PMID:39876989
LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4., PMID:38761175
Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death., PMID:38559813
METTL3 suppresses invasion of lung cancer via SH3BP5 m6A modification., PMID:38141906
Expression analysis of PPAR-related lncRNAs in breast cancer., PMID:37820438
Identification and analysis of methylation signature genes and association with immune infiltration in pediatric acute myeloid leukemia., PMID:37606761
Metastasis-related long non-coding RNAs AL359220.1, SH3BP5-AS1 and ZF-AS1 are significant for prognostic assessment of lung adenocarcinoma., PMID:37566767
SH3BP5-AS1/IGF2BP2/VDAC2 Axis Promotes the Apoptosis and Ferroptosis of Bladder Cancer Cells., PMID:38994477
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway., PMID:36397058
Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis., PMID:35778520
Novel blood-based hypomethylation of SH3BP5 is associated with very early-stage lung adenocarcinoma., PMID:34783986
Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis., PMID:34331779
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs., PMID:34128958
Selective inhibition of JNK mitochondrial location is protective against seawater inhalation‑induced ALI/ARDS., PMID:34013361
Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease., PMID:33441550
The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity., PMID:33277614
Changes in expressions of genes involved in the regulation of cellular processes in mucopolysaccharidoses as assessed by fibroblast culture-based transcriptomic analyses., PMID:32886284
trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop., PMID:32066809
Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells., PMID:31546831
Identification of important invasion and proliferation related genes in adrenocortical carcinoma., PMID:31321566
Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure., PMID:31029706
Phosphoregulation on mitochondria: Integration of cell and organelle responses., PMID:31025544
Clinically Relevant Biomarker Discovery in High-Risk Recurrent Neuroblastoma., PMID:30886518
Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5., PMID:30872413
The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects., PMID:30463289
Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines., PMID:30322886
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5., PMID:30217979
The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases., PMID:29273580
Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype., PMID:29106825
The role of MAP2 kinases and p38 kinase in acute murine liver injury models., PMID:28661486
Sab is differentially expressed in the brain and affects neuronal activity., PMID:28606781
REI-1, a Novel Rab11 GEF with a SH3BP5 domain., PMID:28003861
Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib., PMID:27993968
[Role of miR137-MITF in Prognostic Analysis of Multiple Myeloma]., PMID:27531781
Expressions of SH3BP5, LMO3, and SNAP25 in diffuse large B-cell lymphoma cells and their association with clinical features., PMID:27184832
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src., PMID:26845758
REI/SH3BP5 protein family: New GEFs for Rab11., PMID:26745340
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity., PMID:25666017
Apollon/Bruce is upregulated by Humanin., PMID:25138702
SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase., PMID:23861391
Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo., PMID:23184940
Structural mechanisms of allostery and autoinhibition in JNK family kinases., PMID:23142346
c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice., PMID:21844199
Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1)., PMID:21563797
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain., PMID:19290921
Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5., PMID:19161832
Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray., PMID:15757668
For research use only. Not for human or drug use.
