Catalog No.
YHG53902
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser13-Lys252
Predicted molecular weight
28.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13451
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AIG6, 51 kDa FKBP, FKBP51, FKBP54, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP5, FF1 antigen, 51 kDa FK506-binding protein, FKBP-51, Androgen-regulated protein 6, p54, PPIase FKBP5, 54 kDa progesterone receptor-associated immunophilin, HSP90-binding immunophilin, FKBP-5, FK506-binding protein 5, FKBP5
Inhibition of FKBP5 Alleviates Inflammation and Intestinal Barrier Dysfunction in Sepsis., PMID:40465383
Temporomandibular joint disorders, happiness, and COMT, HTR2A and FKBP5 polymorphisms in adolescents: a cross-sectional study., PMID:40435063
Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors., PMID:40399551
Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7., PMID:40391431
FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway., PMID:40345291
FKBP51 protects hair cells of utricles from gentamicin-induced toxicity in vitro: possible relation to the activities of NF-κB signaling pathway., PMID:40324675
Lithium Treatment Increases FKBP5 Protein but Not mRNA Expression in the Pituitary Gland of Depressive-like Rats., PMID:40309821
Increased HSD11β1 Expression in Human Leiomyomatous Uteri: Implication for Enhanced Glucocorticoid Signaling., PMID:40290045
FKBP5 Induces Senescence in BMSCs and Inhibits Osteogenic Differentiation Through the Canonical WNT/β-Catenin Signalling Pathway in Senile Osteoporosis., PMID:40254776
Personalized Prophylactic Antiemetic Regimens for Control of Chemotherapy-Induced Nausea and Vomiting by Pharmacogenetic Analysis of Three Receptor Genes: HTR3A, HTR3B, TACR1., PMID:40249884
Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations., PMID:40243774
The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape., PMID:40242984
Mechanisms by which sevoflurane affects cognitive function in aged marmosets and mice: up-regulation of FKBP5 expression in brain microglia., PMID:40235085
Effect of chronic corticosterone administration on acute stress-mediated gene expression in the cortex and hippocampus of male mice., PMID:40199127
FKBP5 mediates glucocorticoid signaling in estrogen deficiency-associated endothelial dysfunction., PMID:40185321
A depression-associated protein FKBP5 functions in autophagy initiation through scaffolding the VPS34 complex., PMID:40175715
Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer., PMID:40173332
Alteration of Ubiquitination in the Brain of ENOPH1 Knockout Mice after Early Ischemic Stroke., PMID:40170525
FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model., PMID:40152573
The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral Phenotypes., PMID:40149476
Depletion of Fkbp5 Protects Against the Rapid Decline in Ovarian Reserve Induced by Prenatal Stress in Female Offspring of Wild-Type Mice., PMID:40141115
HPA-axis multilocus genetic interaction with stress life events in predicting changes in adolescent suicidal ideation., PMID:40139404
Dioscin alleviates the dysfunction of fibroblast-like synoviocytes by circ_0008267/miR-942-5p/FKBP5 axis during rheumatoid arthritis., PMID:40116870
Inhibition of LINC00707/miR-223-3p/FKBP5 axis has a protective effect on diabetic kidney disease., PMID:40114624
Molecular pathways of ketamine: A systematic review of immediate and sustained effects on PTSD., PMID:40097854
Targeting FKBP51 prevents stress-induced preterm birth., PMID:40097636
In silico identification of novel ligands targeting stress-related human FKBP5 protein in mental disorders., PMID:40096182
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice., PMID:40087272
Epigenetics in persons living with HIV: trauma, coping, and FKBP5 and SLC6A4 methylation., PMID:40069093
Cardioprotective potential of transcription factor PRRX1 silencing against myocardial ischemia/reperfusion injury by regulating excessive mitophagy and ferroptosis through FKBP5-p38 MAPK axis., PMID:40044064
A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae., PMID:40033010
Delving Into the Interaction Between Exercise and Diabetes on Methylation of the FKBP5 Gene., PMID:40017583
A polyepigenetic glucocorticoid exposure score and HPA axis-related DNA methylation are associated with gestational epigenetic aging., PMID:40007075
Exploring the role of glucocorticoid receptors and co-chaperones in Pemphigus foliaceus stratification., PMID:39988616
FKBP51 functions in the regulation of circadian rhythm and Alzheimer's disease., PMID:39933601
FKBP51 inhibition ameliorates neurodegeneration and motor dysfunction in the neuromelanin-SNCA mouse model of Parkinson's disease., PMID:39905728
Unraveling the gender-specific molecular landscape of lung squamous cell carcinoma progression., PMID:39895519
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models., PMID:39890919
Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma., PMID:39868576
Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis., PMID:39839219
Enhanced ovarian FKBP51 expression is associated with ovarian aging: a molecular insight for age-related fertility in women., PMID:39837475
Androgens differentially modulate glucocorticoid effects on adipose tissue and lean mass., PMID:39831834
Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation., PMID:39809798
Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice., PMID:39768133
Deeply Saddening Life Events Play a Carcinogenic Role by Inducing Mutations in ALOX12 and FKBP5 Genes., PMID:39766798
Conformationally Restricted Macrocycles as Improved FKBP51 Inhibitors Enabled by Systematic Linker Derivatization., PMID:39752587
Association Between Stress-Induced Weight Loss and Autophagy-Related Gene Expression in the Hippocampus and Midbrain of Depression Model Mice., PMID:39715728
Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults., PMID:39707707
SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4-FKBP5 interactions in neurons., PMID:39705315
Response strategies to acute and chronic environmental stress in the arctic breeding Lapland longspur (Calcarius lapponicus)., PMID:39702772
For research use only. Not for human or drug use.
