Catalog No.
YHB81301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys4-Glu253
Predicted molecular weight
30.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95983
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Methyl-CpG-binding protein MBD3, Methyl-CpG-binding domain protein 3, MBD3
LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression., PMID:40413520
PTMA controls cardiomyocyte proliferation and cardiac repair by enhancing STAT3 acetylation., PMID:40408476
Uncovering the Molecular Interactions Underlying MBD2 and MBD3 Phase Separation., PMID:40350613
c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells., PMID:39876710
Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors., PMID:39793578
Distinct deregulation trends of transcriptional protein complexes in aging naive T cells., PMID:39437255
Exploring the Role of E6 and E7 Oncoproteins in Cervical Oncogenesis through MBD2/3-NuRD Complex Chromatin Remodeling., PMID:38790189
Uncovering the molecular interactions underlying MBD2 and MBD3 phase separation., PMID:38746378
m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD., PMID:38453794
Comparison of hypoxia- and hyperoxia-induced alteration of epigene expression pattern in lungs of Pleurodeles waltl and Mus musculus., PMID:38416753
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway., PMID:38178023
The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells., PMID:38149716
A paradigm for post-embryonic Oct4 re-expression: E7-induced hydroxymethylation regulates Oct4 expression in cervical cancer., PMID:38054553
CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia., PMID:37686014
Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing., PMID:37552759
MBD3 Regulates Male Germ Cell Division and Sperm Fertility in Arabidopsis thaliana., PMID:37514268
Clinical significance of serum MBD3 detection in girls with central precocious puberty., PMID:37426049
Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation., PMID:37385984
Identification of signature genes and drug candidates for primary plasma cell leukemia: An integrated system biology approach., PMID:37295388
Parental Preconception and Pre-Hatch Exposure to a Developmental Insult Alters Offspring's Gene Expression and Epigenetic Regulations: An Avian Model., PMID:36902484
An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment., PMID:36253406
Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B., PMID:36070320
Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination., PMID:36040254
Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3., PMID:36037972
Nucleosome remodeling and deacetylation complex and MBD3 influence mouse embryonic stem cell naïve pluripotency under inhibition of protein kinase C., PMID:35915078
MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2., PMID:35501390
Maternal serum-derived exosomal lactoferrin as a marker in detecting and predicting ventricular septal defect in fetuses., PMID:34871505
Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers., PMID:34592200
Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development., PMID:34359703
Methyl-CpG-Binding Domain Protein 3 Promotes Seizures by Recruiting Methyltransferase DNMT1 to Enhance TREM2 Methylation., PMID:34173118
AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency., PMID:34088849
Long-term exposure to particulate matter from air pollution alters airway β-defensin-3 and -4 and cathelicidin host defense peptides production in a murine model., PMID:34052349
MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty., PMID:33744966
Role of MBD3-SOX2 axis in residual myeloma following pomalidomide., PMID:33603141
Methyl-CpG-binding domain 3 (Mbd3) is an important regulator for apoptosis in mouse embryonic stem cells., PMID:33437388
Phospholipase C epsilon mediates cytokine cascade induced by acute disruption of epidermal permeability barrier in mice., PMID:33336085
Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model., PMID:33174148
Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma., PMID:33016927
Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells., PMID:33014158
Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells., PMID:32975208
Methyl-CpG binding domain protein 3: a new diagnostic marker and potential therapeutic target of melanoma., PMID:32963182
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution., PMID:32796851
Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells., PMID:32718272
Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania., PMID:32503527
Methyl-CpG-binding domain 3 inhibits stemness of pancreatic cancer cells via Hippo signaling., PMID:32422133
Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex-mediated STAT1 downregulation., PMID:32181805
Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States., PMID:32132616
Expression of key genes involved in DNA methylation during in vitro differentiation of porcine mesenchymal stem cells (MSCs) into adipocytes., PMID:31791576
A new target for fetal hemoglobin reactivation., PMID:31787612
Histone deacetylases, Mbd3/NuRD, and Tet2 hydroxylase are crucial regulators of epithelial-mesenchymal plasticity and tumor metastasis., PMID:31666683