Catalog No.
YHH20901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val55-Arg238
Predicted molecular weight
23.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15825
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHRNA6, Neuronal acetylcholine receptor subunit alpha-6
Potential immunologic and prognostic roles of CHRNA6 in SCLC and pan-cancer., PMID:39398083
Neonicotinoids differentially modulate nicotinic acetylcholine receptors in immature and antral follicles in the mouse ovary†., PMID:38713677
Dopamine and Norepinephrine Tissue Levels in the Developing Limbic Brain Are Impacted by the Human CHRNA6 3'-UTR Single-Nucleotide Polymorphism (rs2304297) in Rats., PMID:38612487
CHRNA6 RNA In Situ Hybridization Is a Useful Tool for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma., PMID:38447752
Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification., PMID:38291367
Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease., PMID:37680128
Expression and role of nicotinic acetylcholine receptors during midbrain dopaminergic neuron differentiation from human induced pluripotent stem cells., PMID:37366076
Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3'-UTR of the CHRNA6 Gene., PMID:35328565
Several nAChRs gene variants are associated with phenotypes of heroin addiction in Chinese Han population., PMID:35176404
Inhibition of TRPC1, TRPM4 and CHRNA6 ion channels ameliorates depression-like behavior in rats., PMID:35063497
LSAMP Rearrangement in Acute Myeloid Leukemia With a Jumping Translocation Involving 3q13.31., PMID:33303723
Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε., PMID:32776643
Transcriptome Analysis Reveals the Neuro-Immune Interactions in Duck Tembusu Virus-Infected Brain., PMID:32244328
Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism., PMID:32120303
Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function., PMID:31369741
The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers., PMID:29751336
Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders., PMID:29388323
Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population., PMID:28851948
[Possible involvement of neuronal nicotinic acetylcholine receptors in compensatory brain mechanisms at early stages of Parkinson's disease]., PMID:28781257
α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption., PMID:28457669
Modulation of ethanol reward sensitivity by nicotinic acetylcholine receptors containing the α6 subunit., PMID:27793544
Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research., PMID:27327258
Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence., PMID:27085880
Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder., PMID:26184988
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors., PMID:25972004
A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations., PMID:25823894
Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma., PMID:25233467
Transcriptome analysis of CNS immediately before and after the detection of PrP(Sc) in SSBP/1 sheep scrapie., PMID:25183238
Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits., PMID:25068303
Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior., PMID:24804708
Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity., PMID:24792900
Commentary on Culverhouse et al. (2014): How genomics can bring us towards health equity., PMID:24720827
Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy., PMID:24675634
ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma., PMID:24479813
Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients., PMID:24451080
Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans., PMID:24401102
Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations., PMID:24253422
The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke., PMID:24119711
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence., PMID:24057674
Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood., PMID:23899432
Nicotinic acetylcholine receptors containing the α6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons., PMID:23811312
Why have tobacco control policies stalled? Using genetic moderation to examine policy impacts., PMID:23227187
Effects of glaucoma on Chrna6 expression in the retina., PMID:23002780
The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation., PMID:22572056
Preclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotype., PMID:22492084
Modulation of gain-of-function α6*-nicotinic acetylcholine receptor by β3 subunits., PMID:22315221
Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence., PMID:22042774
Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) α5 Subunits and/or variants modulate function of α6*-nAChR., PMID:21873428
[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]., PMID:21831805
Associations of nicotine intake measures with CHRN genes in Finnish smokers., PMID:21498873
For research use only. Not for human or drug use.
