Catalog No.
YHB42501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly556-Pro820
Predicted molecular weight
31.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94761
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-dependent DNA helicase Q4, RTS, RECQL4, RECQ4, DNA helicase, RecQ-like type 4, RecQ4, RecQ protein-like 4
Selective interactions at pre-replication complexes categorize baseline and dormant origins., PMID:40319014
Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer., PMID:40196015
RECQL4-related Rothmund-Thomson syndrome: A case series and literature review., PMID:40031098
Targeting RECQL4 in hepatocellular carcinoma: from prognosis to therapeutic potential., PMID:40001159
RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome., PMID:39900600
RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining., PMID:39870799
HER2 expression and pathway status in male breast cancer patients: results of an integrated analysis among 6,150 patients., PMID:39870698
RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma., PMID:39812592
Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome., PMID:39519399
Interaction of RECQL4 with poly(ADP-ribose) is critical for the DNA double-strand break response in human cells., PMID:39462683
RecQ protein-like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2., PMID:39404003
Severe Phenotype With RECQL4 Syndrome: A Report of Two Cases., PMID:39324487
Atypical presentations of RECQL4-related syndromes., PMID:39315607
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication., PMID:39284827
Differentially localized protein identification for breast cancer based on deep learning in immunohistochemical images., PMID:39095659
Identification of Key Genes Associated with Polycystic Ovarian Syndrome and Endometrial and Ovarian Cancer through Bioinformatics., PMID:39091436
Computational identification of mitochondrial dysfunction biomarkers in severe SARS-CoV-2 infection: Facilitating therapeutic applications of phytomedicine., PMID:38878325
RecQ helicase expression in patients with telomeropathies., PMID:38874681
Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa., PMID:38866019
Single-Molecule Imaging Reveals the Mechanism of Bidirectional Replication Initiation in Metazoa., PMID:38585807
RECQL4 is not critical for firing of human DNA replication origins., PMID:38565932
Characteristics of germline DNA damage response gene mutations in ovarian cancer in Southwest China., PMID:38509102
RECQL4 Inhibits Radiation-Induced Tumor Immune Awakening via Suppressing the cGAS-STING Pathway in Hepatocellular Carcinoma., PMID:38381090
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication., PMID:38260523
DONSON: Slding in 2 the limelight., PMID:38159447
PABPN1 functions as a predictive biomarker in colorectal carcinoma., PMID:38158471
Rothmund-Thomson syndrome, a disorder far from solved., PMID:38021400
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase., PMID:37875529
Multigene Panel Sequencing Identifies a Novel Germline Mutation Profile in Male Breast Cancer Patients., PMID:37762649
TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway., PMID:37516854
Rif1 restrains the rate of replication origin firing in Xenopus laevis., PMID:37516798
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy., PMID:37495109
A Novel Germline Pathogenic Variant of RECQL4 Gene in an Iranian Pedigree with Familial Squamous Cell Carcinoma: A Brief Report., PMID:37456212
De novo myelodysplastic syndrome in a Rothmund-Thomson Syndrome patient with novel pathogenic RECQL4 variants., PMID:37228773
Biallelic variants in DNA2 cause poikiloderma with congenital cataracts and severe growth failure reminiscent of Rothmund-Thomson syndrome., PMID:37055165
Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence., PMID:37013901
Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos., PMID:36970058
RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice., PMID:36948261
Germline NUP98 Variants in Two Siblings with a Rothmund-Thomson-Like Spectrum: Protein Functional Changes Predicted by Molecular Modeling., PMID:36835439
Genomic alterations and clinical outcomes in patients with dedifferentiated liposarcoma., PMID:36464833
Deubiquitinase USP2 stabilizes the MRE11-RAD50-NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1., PMID:36436562
Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer., PMID:36126066
Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate., PMID:35817949
RecQ Helicase Somatic Alterations in Cancer., PMID:35782872
The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma., PMID:35780451
DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks., PMID:35580045
Skin Lesions Associated With a New Mutation in the RECQL4 Gene in a Patient With Osteosarcoma., PMID:35489969
Thyroid Follicular Cell-derived Carcinomas in a Background of Multiple Adenomatous Nodules Leading to a Diagnosis of PTEN Hamartoma Tumor Syndrome in an Adult Patient With a Novel RECQL4 Mutation., PMID:35220242
Cancer risk among RECQL4 heterozygotes., PMID:35219053
Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome., PMID:34965247
For research use only. Not for human or drug use.
