Catalog No.
YHJ00701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp27-Arg256
Predicted molecular weight
28.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5FWF4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Annealing helicase 2, ZRANB3, Zinc finger Ran-binding domain-containing protein 3, AH2, DNA annealing helicase and endonuclease ZRANB3
Profound synthetic lethality between SMARCAL1 and FANCM., PMID:39510066
RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes., PMID:39116203
DNA fork remodeling proteins, Zranb3 and Smarcal1, are uniquely essential for aging hematopoiesis., PMID:39044358
MRNIP limits ssDNA gaps during replication stress., PMID:38917325
The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage., PMID:38321962
Methylation Levels in the Promoter Region of FHIT and PIAS1 Genes Associated with Mastitis Resistance in Xinjiang Brown Cattle., PMID:37372369
Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability., PMID:37058556
RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks., PMID:37036693
PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair., PMID:36512630
Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal., PMID:36476850
Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex., PMID:35801922
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells., PMID:34871413
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage., PMID:34645815
Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices., PMID:34165573
Making Choices: DNA Replication Fork Recovery Mechanisms., PMID:33967572
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets., PMID:33523105
The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability., PMID:33296677
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease., PMID:32971328
Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis., PMID:32685554
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links., PMID:32354836
Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis., PMID:31836351
The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase., PMID:31734537
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response., PMID:31324766
Remodeling Collapsed DNA Replication Forks for Cancer Development., PMID:30936075
Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress., PMID:30610086
ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links., PMID:30184498
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3., PMID:30150681
The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression., PMID:29643183
Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction., PMID:29633969
Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe., PMID:29290468
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers., PMID:29053959
Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability., PMID:28954549
Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity., PMID:28886337
RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks., PMID:28735897
Structural insights into the function of ZRANB3 in replication stress response., PMID:28621305
Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ., PMID:27445336
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression., PMID:27407148
SMARCAL1 and telomeres: Replicating the troublesome ends., PMID:27355316
Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3)., PMID:26884333
SMARCAL1 maintains telomere integrity during DNA replication., PMID:26578802
Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway., PMID:25412445
Substrate-selective repair and restart of replication forks by DNA translocases., PMID:23746452
Angelman syndrome and severe infections in a patient with de novo 15q11.2-q13.1 deletion and maternally inherited 2q21.3 microdeletion., PMID:23124039
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response., PMID:22759634
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress., PMID:22705370
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress., PMID:22704558
Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif., PMID:21078962
For research use only. Not for human or drug use.
