Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. PMID: 32450052
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. PMID: 35287553
Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis. PMID: 32324083
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons. PMID: 33111641
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization. PMID: 34802379
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. PMID: 31441382
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. PMID: 32048886
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions. PMID: 35196191
Sex differences in autophagy-mediated diseases: toward precision medicine. PMID: 32264724
ATM loss disrupts the autophagy-lysosomal pathway. PMID: 32757690
CREG1 promotes lysosomal biogenesis and function. PMID: 33966596
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. PMID: 30917721
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. PMID: 30304977
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. PMID: 31856641
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice. PMID: 31942816
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. PMID: 31944172
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). PMID: 33622188
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. PMID: 31238788
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. PMID: 30909789
Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis. PMID: 34872436
KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. PMID: 32160081
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. PMID: 30957628
Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. PMID: 33706671
GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions. PMID: 34740311
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. PMID: 34313548
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3. PMID: 35230915
Autophagy in farm animals: current knowledge and future challenges. PMID: 32686564
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. PMID: 30612517
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling. PMID: 31204557
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease. PMID: 34313551
Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. PMID: 35659195
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis. PMID: 31282275
Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes. PMID: 31690173
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models. PMID: 35000546
Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes. PMID: 26042865
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis. PMID: 34338148
Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy. PMID: 34403298
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells. PMID: 30990357
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. PMID: 33459145
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. PMID: 30145925
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation. PMID: 33618632
A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. PMID: 30806145
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure. PMID: 28694354
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress. PMID: 36719671
Detection of SNPs in the cathepsin D gene and their association with yolk traits in chickens. PMID: 23431385
Vacuolar hydrolysis and efflux: current knowledge and unanswered questions. PMID: 30422029
Osteoprotegerin predicts cardiovascular events in patients treated with haemodialysis. PMID: 34086939
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218. PMID: 34729308
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. PMID: 25484084
Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport. PMID: 32397873
OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin. PMID: 35253614
Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mouse: technical and biological considerations. PMID: 34674604
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block. PMID: 32079455
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. PMID: 30269645
Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide. PMID: 25719862
SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. PMID: 27929705
Immunohistochemical analysis of macroautophagy: recommendations and limitations. PMID: 23242143
Cathepsin-mediated regulation of autophagy in saposin C deficiency. PMID: 23108186
Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells. PMID: 30078345
YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. PMID: 30653408
Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury. PMID: 27150525
Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. PMID: 26727396
Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner. PMID: 32046625
[Cathepsin B Affects the Activation of Nucleotide-binding Domain and Leucine-rich-repeat-containing Family and Pyrin Domain-containing 3 Inflammasome via Transient Receptor Potential Mucolipin-1]. PMID: 31060676
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43. PMID: 31242080
Analysis of specific mRNA gene expression profiles as markers of egg and embryo quality for hybrid catfish aquaculture. PMID: 32081738
Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. PMID: 26102061
Reference genes to quantify gene expression during oogenesis in a teleost fish. PMID: 22750322
Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. PMID: 24401568
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium. PMID: 26075877
Effects of different light spectra on embryo development and the performance of newly hatched turbot (Scophthalmus maximus) larvae. PMID: 31071463
Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans. PMID: 22885761
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. PMID: 36843263
Construction of epilepsy diagnosis model based on cell senescence-related genes and its potential mechanism., PMID:40520613
A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals., PMID:40507347
Proteomics-Based Exploration of the Hepatoprotective Mechanism of α-Lipoic Acid in Rats with Iron Overload-Induced Liver Injury., PMID:40429916
Autophagy Process in Parkinson's Disease Depends on Mutations in the GBA1 and LRRK2 Genes., PMID:40388077
Inhibiting Immune Crosstalk by Modulation of the Intracellular Function and Extracellular Environment of Diseased Microglia to Boost Parkinson's Disease Therapy., PMID:40366277
[Rubioncolin C targets cathepsin D to induce autophagosome accumulation and suppress gastric cancer]., PMID:40350910
Characterization, expression profiling, and immunological role of Cathepsin D in Sebastes schlegelii during bacterial infection., PMID:40339947
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux., PMID:40280227
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells., PMID:40181129
Glycosylation Triggers Cathepsin D Maturation and Secretion to Promote Gastric Cancer Development., PMID:40122458
Integrated Proteomics and Lipidomics Analysis of Hippocampus to Reveal the Metabolic Landscape of Epilepsy., PMID:40092809
Function of lamp2 Gene Response to Vibrio vulnificus Infection and LPS Stimulation in the Half-Smooth Tongue Sole (Cynoglossus semilaevis)., PMID:40076623
Effects of Dietary Copper Sources and Levels on Liver Copper Metabolism and the Expression of Transporters in Growing Pigs., PMID:40003008
Genetic colocalization of cathepsins H, D, and L1 with Alzheimer's disease: Implications for biomarker and therapeutic target discovery., PMID:39982062
From protective enzyme to facilitator of amyloid propagation: Cathepsin D-mediated amyloid fibril fragmentation., PMID:39952498
Vasoinhibin is Generated by the Renin-angiotensin System., PMID:39903548
Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy., PMID:39800383
Low-density lipoprotein receptor-related protein 6 ameliorates cardiac hypertrophy by regulating CTSD/HSP90α signaling during pressure overload., PMID:39779966
The Expression of Proteases and the Oligopeptide Transporter PepT1 in the Yolk Sac Membrane, Proventriculus, and Small Intestine During the Development of Anas platyrhynchos domestica Embryo., PMID:39765655
Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H+-ATPase., PMID:39757940
Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model., PMID:39744681
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis., PMID:39726152
N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer., PMID:39716927
AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity., PMID:39675352
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration., PMID:39675125
A Novel Variant of the CTSD Gene Associated with Juvenile-onset Neuronal Ceroid Lipofuscinosis Type 10: A Case Report and Literature Review., PMID:39656415
Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure., PMID:39616671
Vitamin D promotes autophagy to inhibit LPS-induced lung injury via targeting cathepsin D., PMID:39570382
New preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry., PMID:39520708
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α., PMID:39477683
Transcriptome Analysis Reveals the Early Development in Subcutaneous Adipose Tissue of Laiwu Piglets., PMID:39457885
A combined analysis of bulk RNA-seq and scRNA-seq was performed to investigate the molecular mechanisms associated with the occurrence of myocardial infarction., PMID:39363266
Cleistanthin A derivative disrupts autophagy and suppresses head and neck squamous cell carcinoma progression via targeted vacuolar ATPase., PMID:39343784
Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis., PMID:39263947
AUF1-mediated inhibition of autophagic lysosomal degradation contributes to CagA stability and Helicobacter pylori-induced inflammation., PMID:39068523
Dietary fishmeal replacement by Clostridium autoethanogenum protein meal influences the nutritional and sensory quality of turbot (Scophthalmus maximus) via the TOR/AAR/AMPK pathways., PMID:39056058
Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions., PMID:39051237
Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting., PMID:39032642
Pro-cathepsin D prevents aberrant protein aggregation dependent on endoplasmic reticulum protein CLN6., PMID:39032464
Lipopolysaccharide-Induced Lysosomal Cell Death Through Reactive Oxygen Species in Rat Liver Cell Clone 9., PMID:39031462
Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis., PMID:39019115
Lassa virus Z protein hijacks the autophagy machinery for efficient transportation by interrupting CCT2-mediated cytoskeleton network formation., PMID:39007910
Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons., PMID:38928416
Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis., PMID:38863498
Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain., PMID:38854113
Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis., PMID:38837708
Late-onset Krabbe disease presenting as spastic paraplegia - implications of GCase and CTSB/D., PMID:38837642
Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit., PMID:38815149
[Associations of serum neuromarkers with clinical features of Parkinson's disease]., PMID:38676689
For research use only. Not for human or drug use.
