Catalog No.
YHC25302
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg23-Leu412
Predicted molecular weight
44.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07339
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CPSD, CTSD, Cathepsin D
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. PMID: 32450052
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. PMID: 35287553
Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis. PMID: 32324083
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons. PMID: 33111641
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization. PMID: 34802379
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. PMID: 31441382
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. PMID: 32048886
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions. PMID: 35196191
Sex differences in autophagy-mediated diseases: toward precision medicine. PMID: 32264724
ATM loss disrupts the autophagy-lysosomal pathway. PMID: 32757690
CREG1 promotes lysosomal biogenesis and function. PMID: 33966596
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. PMID: 30917721
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. PMID: 30304977
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. PMID: 31856641
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice. PMID: 31942816
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. PMID: 31944172
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). PMID: 33622188
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. PMID: 31238788
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. PMID: 30909789
Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis. PMID: 34872436
KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. PMID: 32160081
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. PMID: 30957628
Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. PMID: 33706671
GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions. PMID: 34740311
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. PMID: 34313548
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3. PMID: 35230915
Autophagy in farm animals: current knowledge and future challenges. PMID: 32686564
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. PMID: 30612517
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling. PMID: 31204557
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease. PMID: 34313551
Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. PMID: 35659195
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis. PMID: 31282275
Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes. PMID: 31690173
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models. PMID: 35000546
Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes. PMID: 26042865
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis. PMID: 34338148
Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy. PMID: 34403298
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells. PMID: 30990357
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. PMID: 33459145
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. PMID: 30145925
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation. PMID: 33618632
A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. PMID: 30806145
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure. PMID: 28694354
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress. PMID: 36719671
Detection of SNPs in the cathepsin D gene and their association with yolk traits in chickens. PMID: 23431385
Vacuolar hydrolysis and efflux: current knowledge and unanswered questions. PMID: 30422029
Osteoprotegerin predicts cardiovascular events in patients treated with haemodialysis. PMID: 34086939
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218. PMID: 34729308
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. PMID: 25484084
Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport. PMID: 32397873
OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin. PMID: 35253614
Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mouse: technical and biological considerations. PMID: 34674604
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block. PMID: 32079455
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. PMID: 30269645
Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide. PMID: 25719862
SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. PMID: 27929705
Immunohistochemical analysis of macroautophagy: recommendations and limitations. PMID: 23242143
Cathepsin-mediated regulation of autophagy in saposin C deficiency. PMID: 23108186
Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells. PMID: 30078345
YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. PMID: 30653408
Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury. PMID: 27150525
Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. PMID: 26727396
Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner. PMID: 32046625
[Cathepsin B Affects the Activation of Nucleotide-binding Domain and Leucine-rich-repeat-containing Family and Pyrin Domain-containing 3 Inflammasome via Transient Receptor Potential Mucolipin-1]. PMID: 31060676
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43. PMID: 31242080
Analysis of specific mRNA gene expression profiles as markers of egg and embryo quality for hybrid catfish aquaculture. PMID: 32081738
Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. PMID: 26102061
Reference genes to quantify gene expression during oogenesis in a teleost fish. PMID: 22750322
Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. PMID: 24401568
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium. PMID: 26075877
Effects of different light spectra on embryo development and the performance of newly hatched turbot (Scophthalmus maximus) larvae. PMID: 31071463
Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans. PMID: 22885761
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. PMID: 36843263
For research use only. Not for human or drug use.
