Catalog No.
YHB73801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly356-Ile552
Predicted molecular weight
24.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95758
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Regulator of differentiation 1, Polypyrimidine tract-binding protein 3, Rod1, PTBP3, ROD1
LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis. PMID: 32384893
PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability. PMID: 35136024
PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial-Mesenchymal Transition in Breast Cancer. PMID: 29187406
PTBP3 regulates proliferation of lung squamous cell carcinoma cells via CDC25A-mediated cell cycle progression. PMID: 35016691
PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α. PMID: 31291975
PTBP3 mediates TGF-β-induced EMT and metastasis of lung adenocarcinoma. PMID: 35323096
PTBP3 promotes malignancy and hypoxia-induced chemoresistance in pancreatic cancer cells by ATG12 up-regulation. PMID: 31989778
PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. PMID: 29752441
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. PMID: 30143796
Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. PMID: 28222070
Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates in Xenopus oocytes. PMID: 35982794
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612. PMID: 30068940
PTBP3 promotes migration of non-small cell lung cancer through regulating E-cadherin in EMT signaling pathway. PMID: 32477006
Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation. PMID: 25940628
PTBP3 Induced Inhibition of Differentiation of Gastric Cancer Cells Through Alternative Splicing of Id1. PMID: 32974175
New Insights Into PTBP3 in Human Cancers: Immune Cell Infiltration, TMB, MSI, PDCD1 and m6A Markers. PMID: 35359851
Circular RNA circ_0006089 promotes the progression of gastric cancer by regulating the miR-143-3p/PTBP3 axis and PI3K/AKT signaling pathway. PMID: 35844201
LncRNA Meg3 protects endothelial function by regulating the DNA damage response. PMID: 30476192
The effects of PTBP3 silencing on the proliferation and differentiation of MKN45 human gastric cancer cells. PMID: 25119103
MiR-384 inhibits proliferation and migration of trophoblast cells via targeting PTBP3. PMID: 32512528
Long non-coding RNA SLC25A21-AS1 inhibits the development of epithelial ovarian cancer by specifically inducing PTBP3 degradation. PMID: 36717926
Chromosome Conformation Capture Reveals Two Elements That Interact with the PTBP3 (ROD1) Transcription Start Site. PMID: 30634466
Identification of Immune Cells and Key Genes associated with Alzheimer's Disease. PMID: 34975305
PTBPs: An immunomodulatory-related prognostic biomarker in pan-cancer. PMID: 36203873
Expression analysis of the polypyrimidine tract binding protein (PTBP1) and its paralogs PTBP2 and PTBP3 during Xenopus tropicalis embryogenesis. PMID: 23124965
Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy. PMID: 36140281
Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice. PMID: 34214192
Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol. PMID: 26657638
LPS Administration Impacts Glial Immune Programs by Alternative Splicing. PMID: 35204777
PTB/nPTB: master regulators of neuronal fate in mammals. PMID: 30310857
ROD1 is a seedless target gene of hypoxia-induced miR-210. PMID: 23024754
Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment. PMID: 33891593
Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex. PMID: 30782962
Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. PMID: 24618292
Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians. PMID: 29394898
A new function of ROD1 in nonsense-mediated mRNA decay. PMID: 22575643
Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea. PMID: 34568429
Human cardiac stem cell differentiation is regulated by a mircrine mechanism. PMID: 21403094
Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1. PMID: 18683239
Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. PMID: 17679092
MicroRNA-210 regulates cell proliferation and apoptosis by targeting regulator of differentiation 1 in glioblastoma cells. PMID: 26443314
Isolation of a mammalian homologue of a fission yeast differentiation regulator. PMID: 10207106
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. PMID: 24499931
Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity. PMID: 19441079
Type 3-specific synthase of Streptococcus pneumoniae (Cap3B) directs type 3 polysaccharide biosynthesis in Escherichia coli and in pneumococcal strains of different serotypes. PMID: 8760798
[Difference of gene expression profile in human gastric cancer grafted onto nude mice treated with WCA]. PMID: 18161298
For research use only. Not for human or drug use.
