Amylin: Pharmacology, Physiology, and Clinical Potential. PMID: 26071095
Creating the amylin story. PMID: 35183619
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics. PMID: 27213520
Development of Cagrilintide, a Long-Acting Amylin Analogue. PMID: 34288673
Long-acting amylin analogues for the management of obesity. PMID: 35066542
Changing times: Fluorescence-lifetime analysis of amyloidogenic SF-IAPP fusion protein. PMID: 30458241
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. PMID: 21742788
Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity. PMID: 28550295
Nonhuman IAPP Variants Inhibit Human IAPP Aggregation. PMID: 34365921
Effect of IAPP on the proteome of cultured Rin-5F cells. PMID: 30419808
The β-cell assassin: IAPP cytotoxicity. PMID: 28811318
Amylin. PMID: 28485843
IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants. PMID: 29378867
Prion-Like Protein Aggregates and Type 2 Diabetes. PMID: 28159831
Type 2 diabetes as a protein misfolding disease. PMID: 25998900
From Peptide Fragments to Whole Protein: Copper(II) Load and Coordination Features of IAPP. PMID: 29111583
IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes. PMID: 34554282
Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation. PMID: 33802170
Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide. PMID: 31155148
In silico studies of the human IAPP in the presence of osmolytes. PMID: 35697975
Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes. PMID: 36589826
Metabolic stress, IAPP and islet amyloid. PMID: 22928566
Plasma IAPP-Autoantibody Levels in Alzheimer's Disease Patients Are Affected by APOE4 Status. PMID: 36835187
In Vivo Mitigation of Amyloidogenesis through Functional-Pathogenic Double-Protein Coronae. PMID: 30088935
On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides. PMID: 26582441
Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide. PMID: 29746093
IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. PMID: 31213603
Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. PMID: 29526462
Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. PMID: 24627476
Amyloidogenic protein-membrane interactions: mechanistic insight from model systems. PMID: 20623810
Islet amyloid toxicity: From genesis to counteracting mechanisms. PMID: 34636428
Quantification of protein aggregation rates and quenching effects of amylin-inhibitor complexes. PMID: 31482893
C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity. PMID: 27566545
Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy. PMID: 28602716
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin. PMID: 35501361
The Role of Cholesterol in Driving IAPP-Membrane Interactions. PMID: 27410742
Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease. PMID: 28528968
Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease. PMID: 25387341
IAPP aggregation and cellular toxicity are inhibited by 1,2,3,4,6-penta-O-galloyl-β-D-glucose. PMID: 23339420
Substoichiometric Inhibition of Insulin against IAPP Aggregation Is Attenuated by the Incompletely Processed N-Terminus of proIAPP. PMID: 35704461
The Molecular Physiopathogenesis of Islet Amyloidosis. PMID: 29043504
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions. PMID: 20814419
The human islet amyloid polypeptide in protein misfolding disorders: Mechanisms of aggregation and interaction with biomembranes. PMID: 33227292
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. PMID: 28765400
Human Amylin: From Pathology to Physiology and Pharmacology. PMID: 30919775
Analysis of Baboon IAPP Provides Insight into Amyloidogenicity and Cytotoxicity of Human IAPP. PMID: 32105649
Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones. PMID: 25406896
Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates. PMID: 26786104
Islet amyloid polypeptide and diabetes. PMID: 23745697
Amyloidogenicity of naturally occurring full-length animal IAPP variants. PMID: 31231935
Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation. PMID: 28078343
CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis. PMID: 26900721
Amylin Pharmacology in Alzheimer's Disease Pathogenesis and Treatment. PMID: 34852745
Clustering polymorphs of tau and IAPP fibrils with the CHEP algorithm. PMID: 33556421
IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans' islets, directly initiates NLRP3 inflammasome activation. PMID: 30014749
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action. PMID: 31863711
Differential Effects of Aromatic Residues on Amyloid Formation and Cytotoxicity of Human IAPP. PMID: 36215164
Insights into amylin-leptin synergy. PMID: 20413324
Misfolded proteins in Alzheimer's disease and type II diabetes. PMID: 21818468
Human IAPP is a contributor to painful diabetic peripheral neuropathy. PMID: 36917177
Newly identified pancreatic protein islet amyloid polypeptide. What is its relationship to diabetes? PMID: 1999270
Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus. PMID: 28582864
Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity. PMID: 23380070
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding. PMID: 28044060
Symmetry-breaking transitions in the early steps of protein self-assembly. PMID: 32123956
The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies. PMID: 29664151
Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies. PMID: 30149632
Aggregation of amylin: Spectroscopic investigation. PMID: 31028814
Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission. PMID: 28108533
A β-hairpin-binding protein for three different disease-related amyloidogenic proteins. PMID: 25557164
Role of amylin and its receptors in neurodegeneration. PMID: 23745698
Conformational dynamics of human IAPP monomers. PMID: 22609945
Molecular Dynamics Simulations Indicate Aromaticity as a Key Factor in the Inhibition of IAPP(20-29) Aggregation. PMID: 35587203
α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice. PMID: 33235246
Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis. PMID: 26576436
Mechanisms of islet amyloidosis toxicity in type 2 diabetes. PMID: 23337872
Peptide amyloid surface display. PMID: 25541905
Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40. PMID: 23956012
Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation. PMID: 29303519
The smaller heparin fragments bind non-specifically through the IAPP sequence: An in silico study. PMID: 29505875
Polymeric micelles as potent islet amyloid inhibitors: Current advances and future perspectives. PMID: 36990145
Copper ions induce dityrosine-linked dimers in human but not in murine islet amyloid polypeptide (IAPP/amylin). PMID: 30737030
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. PMID: 32541896
Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations. PMID: 27179503
Replica exchange molecular dynamics simulation of cross-fibrillation of IAPP and PrP106-126. PMID: 27153477
Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology. PMID: 23266002
Liquid-liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation. PMID: 32414928
Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells. PMID: 28980863
Amylin in Alzheimer's disease: Pathological peptide or potential treatment? PMID: 29233636
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. PMID: 26840340
Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity. PMID: 21630409
Cosolvent effects on the fibrillation reaction of human IAPP. PMID: 23493869
Resveratrol interferes with the aggregation of membrane-bound human-IAPP: a molecular dynamics study. PMID: 25638571
Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition. PMID: 26763863
Novel insight into streptozotocin-induced diabetic rats from the protein misfolding perspective. PMID: 28912603
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. PMID: 25036706
Membrane affinity of individual toxic protein oligomers determined at the single-molecule level. PMID: 32483579
Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas. PMID: 35164285
Cloning and expression of P67 protein of Mycoplasma leachii. PMID: 29062201
Enhanced hydrolysis of lignocellulosic biomass with doping of a highly thermostable recombinant laccase. PMID: 31260768
Production of an Antibody Fragment (scFv) Targeting PcrV Protein of Pseudomonas aeruginosa in Fed-Batch Cultivation Mode. PMID: 34641643
Chemical synthesis uncovers the significant impact of natural glycosylation on islet amyloid polypeptide aggregation., PMID:40531986
Modulation of hIAPP Fibrillation by Rationally Designed Hexapeptides Revealed by Molecular Dynamics and Experimental Investigations., PMID:40523149
Computational theranostics strategy for pancreatic ductal adenocarcinoma., PMID:40522604
Antimicrobial peptides and proteins in Alzheimer's and Parkinson's diseases: implications for biomarker exploration., PMID:40513579
Bridging Pancreatic Amyloidosis and Neurodegeneration: The Emerging Role of Amylin in Diabetic Dementia., PMID:40507832
Author Correction: Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc., PMID:40500304
The Curli Accessory Protein CsgF of Salmonella Typhimurium Influences the in vitro Aggregation of Human Islet Amyloid Polypeptide., PMID:40463484
Coenzyme Q10 Enhances Resilience of Mitochondrial-like Membranes Against Amyloidogenic Peptides., PMID:40422758
Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides., PMID:40417836
Amylin and the amylin receptors in migraine: Is there another pathway to target?, PMID:40388703
Nano-Chaperones: Bridging Therapeutics for Amyloid Aggregation in Alzheimer's Disease and Type-2 Diabetes Mellitus., PMID:40384055
Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment., PMID:40310296
Plant-Based Inhibitors of Protein Aggregation., PMID:40305223
Faster Amylin Aggregation on Fibrillar Collagen I Hastens Diabetic Progression through β-Cell Death and Loss of Function., PMID:40300850
Neuroprotective Role of the Novel GLP-1R Agonist Semaglutide., PMID:40277068
Probing the relationships between self-assembly and the antimicrobial activity of amyloidogenic peptides: The islet amyloid polypeptide as a case study., PMID:40268062
Explaining Type 2 Diabetes with Transcriptomic Signatures of Pancreatic β-Cell Dysfunction and Death Induced by Human Islet Amyloid Polypeptide., PMID:40261698
The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins., PMID:40212812
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors., PMID:40204768
Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease., PMID:40189792
The protective effect of amylin in type 2 diabetes: Yes or no., PMID:40187597
Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway., PMID:40165038
Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms., PMID:40120979
Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus., PMID:40109329
AN INVESTIGATION OF AN AMYLOID-LIKE DEPOSITION DISORDER IN REPTILES., PMID:40067232
The role of amylin, a gut-brain axis hormone, in metabolic and neurological disorders., PMID:40060942
Alkali-extracted rhamnogalactoarabinan from Chaetomorpha linum: Characterisation and anti-type 2 diabetic effect., PMID:40049967
Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells., PMID:40046847
Determinants for Substoichiometric Inhibition of IAPP and Aβ Amyloid Aggregations by Bri2 BRICHOS., PMID:40035576
Drugging Disordered Proteins by Conformational Selection to Inform Therapeutic Intervention., PMID:40029731
Bioinstructive 3D-Printed Magnesium-Baghdadite Bioceramic Scaffolds for Bone Tissue Engineering., PMID:40013831
Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH-promoting GAN diet and a high-fat diet., PMID:39985139
Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug., PMID:39985130
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins., PMID:39950826
Flavones in pomelo peel resist fibril formation of human islet amyloid polypeptide., PMID:39949806
Inhibitory mechanism of lithospermic acid on the fibrillation of type 2 diabetes associated islet amyloid polypeptide., PMID:39919485
Sex-specific signatures of GLP-1 and amylin on resting state brain activity and functional connectivity in awake rats., PMID:39914619
Grapefruit Peel-derived 5,7- Dimethoxycoumarin Enhances Insulin Release and Stimulates Extrapancreatic Secretion of Amylin in Wistar Rats., PMID:39899547
Amylin is incorporated into extracellular vesicles in an ESCRT-dependent manner and regulates senescence., PMID:39892470
Amyloid Targeting-Gold Nanoparticles-Assisted X-ray Therapy Rescues Islet β-Cells from Amyloid Fibrils and Restores Insulin Homeostasis., PMID:39884779
Unveiling the inhibition mechanism of host-defense peptide cathelicidin LL-37 on the amyloid aggregation of the human islet amyloid polypeptide., PMID:39871583
Decoding the Contribution of IAPP Amyloid Aggregation to Beta Cell Dysfunction: A Systematic Review and Epistemic Meta-Analysis of Type 1 Diabetes., PMID:39859479
Structural Analysis of Amylin and Amyloid β Peptide Signaling in Alzheimer's Disease., PMID:39858483
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein., PMID:39822034
Activation of the 20S proteasome as a possible strategy to counteract amylin oligomerization in type 2 diabetes., PMID:39809118
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection., PMID:39806068
Effect and mechanism of oritavancin on hIAPP amyloid formation., PMID:39804635
Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial., PMID:39661009
Identifying the Role of Individual Seal IAPP Amino Acids in Inhibiting the Aggregation of Human IAPP., PMID:39660516
IAPP blocks anti-breast cancer function of CD8+T cells via targeting cuproptosis., PMID:39654888
For research use only. Not for human or drug use.
