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Recombinant Human ADAM15/MDC15 Protein, N-His-SUMO

Catalog #:   YHG53602 Specific References (99) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q13444
Protein length: Pro46-Asp171
Overview

Catalog No.

YHG53602

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Pro46-Asp171

Predicted molecular weight

26.33 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q13444

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Disintegrin and metalloproteinase domain-containing protein 15, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, ADAM15, MDC15, Metalloprotease RGD disintegrin protein, Metargidin, MDC-15, ADAM 15

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human ADAM15/MDC15 protein
References

Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue. PMID: 11592366

Intracellular maturation of the mouse metalloprotease disintegrin MDC15. PMID: 9748307

Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. PMID: 10531379

Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage. PMID: 10513811

ADAM-15: a metalloprotease that mediates inflammation. PMID: 17905725

Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury. PMID: 11102971

Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. PMID: 9516430

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. PMID: 9603986

Protein S is a cofactor for tissue factor pathway inhibitor. PMID: 18691502

Protein degradation: recognition of ubiquitinylated substrates. PMID: 15380085

Protein S and thrombotic disease. PMID: 1535444

Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. PMID: 9835636

The protein-only theory and the yeast Saccharomyces cerevisiae: the prions and the propagons. PMID: 11766884

Resistant protein; its existence and function beneficial to health. PMID: 12026181

Antithrombin III, protein C, and protein S. Naturally occurring anticoagulant proteins. PMID: 2962557

Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulant system. PMID: 1833851

Molecular analysis of the beta-chain of human C4b-binding protein. PMID: 2042026

8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy. PMID: 28213625

Protein S-Nitrosylation of Human Cytomegalovirus pp71 Inhibits Its Ability To Limit STING Antiviral Responses. PMID: 32581105

Dissection of protein translocation across the mitochondrial outer and inner membranes. PMID: 8824435

Studies on the interaction between vitamin K-dependent protein S and complement regulator C4b-binding protein: localization of binding sites and identification of a possible function of the complex. PMID: 12570163

Prions of yeast are genes made of protein: amyloids and enzymes. PMID: 16117685

Functions of outer membrane receptors in mitochondrial protein import. PMID: 12191763

[Protein C (and protein S)]. PMID: 2956435

Sequence and functional relationships between androgen-binding protein/sex hormone-binding globulin and its homologs protein S, Gas6, laminin, and agrin. PMID: 9292933

[Protein C, protein S, protein Z]. PMID: 15658423

Failure of the synthetic androgen, danazol, to increase protein S levels and prevent thrombosis in a patient with severe protein S deficiency. PMID: 7607583

Protein content of molar-incisor hypomineralisation enamel. PMID: 20447437

The interaction between complement component C4b-binding protein and the vitamin K-dependent protein S forms a link between blood coagulation and the complement system. PMID: 1831349

The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex. PMID: 31364267

Protein S in the first year of life. PMID: 2527552

Protein breakdown. Ubiquitous déjà vu. PMID: 9759715

New vitamin K-dependent plasma proteins, protein C and protein S. PMID: 3014792

Protein S and C4b-binding protein levels in patients with stroke: implications for protein S regulation. PMID: 8276319

Regulating G protein signaling. PMID: 8599078

Assembly of protein S and C4b-binding protein on membranes. PMID: 2144523

Displaying a recombinant protein on flocs self-produced by Escherichia coli through fused expression with elongation factor Ts. PMID: 29108623

Heterozygous protein-S deficiency: a study of a large kindred. PMID: 2147089

[RNA binding protein Mei2, a master regulator of meiosis]. PMID: 12696147

Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein. PMID: 2943733

Inhibition of cofactor activity of protein S by a complex of protein S and C4b-binding protein. Evidence for inactive ternary complex formation between protein S, C4b-binding protein, and activated protein C. PMID: 2140568

Identification of a new protein involved in the regulation of the anticoagulant activity of activated protein C. Protein S-binding protein. PMID: 2942545

Protein S enhances C4b binding protein interaction with neutrophils. PMID: 8422460

Functional and immunologic protein S levels are decreased during pregnancy. PMID: 2944555

Studies on the measurement of protein S in plasma. PMID: 1833092

Defining protein interactions with yeast actin in vivo. PMID: 7719850

Cloning and expression of P67 protein of Mycoplasma leachii. PMID: 29062201

Enhanced hydrolysis of lignocellulosic biomass with doping of a highly thermostable recombinant laccase. PMID: 31260768

Production of an Antibody Fragment (scFv) Targeting PcrV Protein of Pseudomonas aeruginosa in Fed-Batch Cultivation Mode. PMID: 34641643

ADAMs contribute to triple negative breast cancer via mTORC1 pathway: targeting ADAM-mTOR axis improves efficacy., PMID:40339955

Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma., PMID:40307857

Mechanical forces trigger invasive behavior in synovial fibroblasts through N-cadherin/ADAM15 -dependent modulation of LncRNA H19., PMID:40118917

Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry., PMID:39959291

Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease., PMID:39824903

TFDP1 overexpression promotes apoptosis of nucleus pulposus cells in intervertebral disc degeneration through regulating ADAM15/MMP9 axis., PMID:39815900

VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis., PMID:39656893

Unraveling the role of ADAMs in clinical heterogeneity and the immune microenvironment of hepatocellular carcinoma: insights from single-cell, spatial transcriptomics, and bulk RNA sequencing., PMID:39346916

Association of ADAM family members with proliferation signaling and disease progression in multiple myeloma., PMID:39261477

Characterization of circulating tumor cells in patients with metastatic bladder cancer utilizing functionalized microfluidics., PMID:39173508

Single-cell transcriptomic atlas of taste papilla aging., PMID:39169434

ADAM15 in Fibroblasts: Improving the Matrix Remodeling by Blocking the Action of Transforming Growth Factor-β1., PMID:39048163

Promoter hypermethylation-induced downregulation of ITGA7 promotes colorectal cancer proliferation and migration by activating the PI3K/AKT/NF-κB pathway., PMID:38885843

Genetic-informed proteome-wide scan reveals potential causal plasma proteins for idiopathic pulmonary fibrosis., PMID:38871465

Single-cell analysis defines LGALS1+ fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma., PMID:38862197

Identification of a novel matrix metalloproteinases-related prognostic signature in hepatocellular carcinoma., PMID:38761174

Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones., PMID:38607341

Digital spatial profiling of segmental outflow regions in trabecular meshwork reveals a role for ADAM15., PMID:38394161

Epigenetic Mechanisms Histone Deacetylase-Dependent Regulate the Glioblastoma Angiogenic Matrisome and Disrupt Endothelial Cell Behavior In Vitro., PMID:38272115

Whole-exome sequencing analysis of patent ductus arteriosus in a Japanese macaque (Macaca fuscata)., PMID:37990472

Gender-specific lncRNA-miRNA-mRNA regulatory network to reveal potential genes for primary open-angle glaucoma., PMID:37774963

Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors., PMID:37602921

Shared Genetics and Comorbid Genes of Amyotrophic Lateral Sclerosis and Parkinson's Disease., PMID:37534731

Comparative proteomic analysis of three major extracellular vesicle classes secreted from human primary and metastatic colorectal cancer cells: Exosomes, microparticles, and shed midbody remnants., PMID:37507836

Combining WGCNA and machine learning to construct immune-related EMT patterns to predict HCC prognosis and immune microenvironment., PMID:37480570

Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics., PMID:37388246

Comprehensive bioinformatics and experimental analysis of SH3PXD2B reveals its carcinogenic effect in gastric carcinoma., PMID:37211344

The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand., PMID:37184585

Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors., PMID:36976494

Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease., PMID:36863609

Consistent DNA Hypomethylations in Prostate Cancer., PMID:36613831

The genetic regulation of protein expression in cerebrospinal fluid., PMID:36504281

Profiling the male germline genome to unravel its reproductive potential., PMID:36379263

Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway., PMID:36330793

Genomic Predictors of Brisk Walking Are Associated with Elite Sprinter Status., PMID:36292594

Identifying Novel Genes and Variants in Immune and Coagulation Pathways Associated with Macular Degeneration., PMID:36275200

Prognostic Value of an Integrin-Based Signature in Hepatocellular Carcinoma and the Identification of Immunological Role of LIMS2., PMID:36212176

NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma., PMID:36183976

Detection of ADAM15 in urine from patients with bladder cancer., PMID:35810783

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State., PMID:35736286

The role of YAP1 target gene CTGF in the anoikis resistance of rheumatoid arthritis synovial fibroblasts., PMID:35713503

Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort., PMID:35668171

Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression., PMID:35597804

ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction., PMID:34995785

Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials., PMID:34711247

A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts., PMID:34685689

A Unified Transcriptional, Pharmacogenomic, and Gene Dependency Approach to Decipher the Biology, Diagnostic Markers, and Therapeutic Targets Associated with Prostate Cancer Metastasis., PMID:34680307

ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma., PMID:34426560

Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates., PMID:33673623

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage., PMID:33381768

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human ADAM15/MDC15 Protein, N-His-SUMO [YHG53602]
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