Protein Expression of PTTG1 as a Diagnostic Biomarker in Adrenocortical Carcinoma. PMID: 29218429
Identification of prognostic biomarkers in papillary renal cell carcinoma and PTTG1 may serve as a biomarker for predicting immunotherapy response. PMID: 35037540
ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1. PMID: 30590814
PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival. PMID: 29078751
Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee. PMID: 33749514
ASO Author Reflections: PTTG1 Protein Expression in Adrenocortical Carcinoma. PMID: 30519761
Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation. PMID: 20198633
PTTG1 regulated by miR-146a-3p promotes bladder cancer migration, invasion, metastasis and growth. PMID: 27893422
Identification of core genes and outcomes in hepatocellular carcinoma by bioinformatics analysis. PMID: 30525236
The clinical value and biological function of PTTG1 in colorectal cancer. PMID: 28219049
PTTG1 attenuates drug-induced cellular senescence. PMID: 21858218
FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. PMID: 26264222
Characterization of a polyclonal antibody to human pituitary tumor transforming gene 1 (PTTG1) protein. PMID: 11724901
Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas. PMID: 34645111
Pttg1 Promotes Growth of Breast Cancer through P27 Nuclear Exclusion. PMID: 26824458
PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines. PMID: 27766744
A Comprehensive Pan-Cancer Analysis for Pituitary Tumor-Transforming Gene 1. PMID: 35281830
PKMYT1 as a Potential Target to Improve the Radiosensitivity of Lung Adenocarcinoma. PMID: 32411179
SP1-mediated transcriptional activation of PTTG1 regulates the migration and phenotypic switching of aortic vascular smooth muscle cells in aortic dissection through MAPK signaling. PMID: 34400144
Roles of miR-186 and PTTG1 in colorectal neuroendocrine tumors. PMID: 26885189
The Clinical Significance and Potential Molecular Mechanism of PTTG1 in Esophageal Squamous Cell Carcinoma. PMID: 33552118
Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. PMID: 24395789
PTTG1 is involved in TNF-α-related hepatocellular carcinoma via the induction of c-myc. PMID: 31385458
PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma. PMID: 26445238
Unravelling the diagnostic and therapeutic potentialities of a novel RNA aptamer isolated against human pituitary tumour transforming gene 1 (PTTG1) protein. PMID: 33161980
Targeting the PTTG1 oncogene impairs proliferation and invasiveness of melanoma cells sensitive or with acquired resistance to the BRAF inhibitor dabrafenib. PMID: 29371923
Antitumor effect of F-PBF(beta-TrCP)-induced targeted PTTG1 degradation in HeLa cells. PMID: 18977400
Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells. PMID: 24879625
PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation. PMID: 24627133
SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression. PMID: 35730625
Elevated PTTG1 predicts poor prognosis in kidney renal clear cell carcinoma and correlates with immunity. PMID: 36793955
Suppression of PTTG1 inhibits cell angiogenesis, migration and invasion in glioma cells. PMID: 32725378
Pttg1 inhibits TGFβ signaling in breast cancer cells to promote their growth. PMID: 25227666
Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma. PMID: 36059148
PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression. PMID: 37159932
PTTG1/securin modulates microtubule nucleation and cell migration. PMID: 21937724
Down-regulation of the oncogene PTTG1 via the KLF6 tumor suppressor during induction of myeloid differentiation. PMID: 23977008
[MiR-300 inhibits invasion and metastasis of osteosarcoma cell MG63 by negatively regulating PTTG1]. PMID: 33624604
[Expression of PTTG1 in gastric adenocarcinoma tissues and its relationship with prognosis]. PMID: 33752310
PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer. PMID: 31482269
ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation. PMID: 34296320
Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis. PMID: 32170852
[Full and D-Box-Deficient PTTG1 Isoforms: Effects on Cell Proliferation]. PMID: 36475495
PTTG1 knockdown enhances radiation-induced antitumour immunity in lung adenocarcinoma. PMID: 33984357
Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression. PMID: 21181309
Upregulation of PTTG1 is associated with poor prognosis in prostate cancer. PMID: 32314536
PTTG1, A novel androgen responsive gene is required for androgen-induced prostate cancer cell growth and invasion. PMID: 27756608
Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression. PMID: 32272902
MicroRNA-329-mediated PTTG1 downregulation inactivates the MAPK signaling pathway to suppress cell proliferation and tumor growth in cholangiocarcinoma. PMID: 30582202
The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas. PMID: 30268327
Protein Expression of PTTG-1, OCT-4, and KLF-4 in Seminoma: A Pilot Study. PMID: 31572301
Knockdown of PTTG1 inhibits the growth and invasion of lung adenocarcinoma cells through regulation of TGFB1/SMAD3 signaling. PMID: 25816405
CDC20 and PTTG1 are Important Biomarkers and Potential Therapeutic Targets for Metastatic Prostate Cancer. PMID: 33881746
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125. PMID: 22704958
Cell Cycle Changes, DNA Ploidy, and PTTG1 Gene Expression in HTLV-1 Patients. PMID: 32793179
Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. PMID: 16628636
Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression. PMID: 33352510
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population. PMID: 22511756
PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target. PMID: 24238056
A peptide fraction from germinated soybean protein down-regulates PTTG1 and TOP2A mRNA expression, inducing apoptosis in cervical cancer cells. PMID: 22545419
PTTG1 promotes CD34+CD45+ cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury. PMID: 37018988
The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis. PMID: 35050550
Transcriptional targets for pituitary tumor-transforming gene-1. PMID: 19433493
Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. PMID: 18451147
Network analysis of DEGs and verification experiments reveal the notable roles of PTTG1 and MMP9 in lung cancer. PMID: 29387220
Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma. PMID: 22805307
PTTG1 promotes migration and invasion of human non-small cell lung cancer cells and is modulated by miR-186. PMID: 23671127
Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors. PMID: 21757741
Prostate cancer cell response to paclitaxel is affected by abnormally expressed securin PTTG1. PMID: 25122070
Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation. PMID: 19477929
Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells. PMID: 15649325
Inhibition of PTTG1 expression by microRNA suppresses proliferation and induces apoptosis of malignant glioma cells. PMID: 27900021
RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer. PMID: 28827316
PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis. PMID: 35210406
The long non-coding RNA PTTG3P promotes growth and metastasis of cervical cancer through PTTG1. PMID: 30853662
mTOR promotes pituitary tumor development through activation of PTTG1. PMID: 27524416
[Impact of PTTG1 downregulation on cell proliferation, cell cycle and cell invasion of osteosarcoma and related molecular mechanisms]. PMID: 25567598
Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer. PMID: 25627474
Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer. PMID: 31801961
E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. PMID: 19837943
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression. PMID: 17039256
Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer. PMID: 35768832
Pituitary Tumor-Transforming Gene 1/Delta like Non-Canonical Notch Ligand 1 Signaling in Chronic Liver Diseases. PMID: 35805898
Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. PMID: 17325339
Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. PMID: 12554778
Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway. PMID: 34025420
KLF10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microRNA-106b-5p. PMID: 32549754
[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI]. PMID: 32216239
Gene Expression Pattern of ESPL1, PTTG1 and PTTG1IP Can Potentially Predict Response to TKI First-Line Treatment of Patients with Newly Diagnosed CML. PMID: 37174118
Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer. PMID: 16619532
MiRNA-494 inhibits metastasis of cervical cancer through Pttg1. PMID: 25877755
Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer. PMID: 18984771
Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90. PMID: 18347135
Proteomics evaluation of MDA-MB-231 breast cancer cells in response to RNAi-induced silencing of hPTTG. PMID: 31521689
Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells. PMID: 25421944
Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade. PMID: 26894859
Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma. PMID: 18339849
Identification of potential prognostic biomarkers for hepatocellular carcinoma. PMID: 35557563
Cloning and expression of P67 protein of Mycoplasma leachii. PMID: 29062201
Enhanced hydrolysis of lignocellulosic biomass with doping of a highly thermostable recombinant laccase. PMID: 31260768
Production of an Antibody Fragment (scFv) Targeting PcrV Protein of Pseudomonas aeruginosa in Fed-Batch Cultivation Mode. PMID: 34641643
Pituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectives., PMID:40472369
Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study., PMID:40407808
Identification of key biomarker genes in liver hepatocellular carcinoma and kidney renal clear cell carcinoma progression: A shared high-throughput screening and molecular docking method with potentials for targeted therapeutic interventions., PMID:40390492
Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder., PMID:40367801
Four genes shared between rheumatoid arthritis and cervical cancer are associated with cervical cancer prognosis., PMID:40335617
A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precision., PMID:40306500
Valproic acid promotes transcriptional activation of Drd2 by mediating histone acetylation to inhibit the mTOR-Pttg1 signaling axis and exerts anti-PitNETs activity., PMID:40220407
Transcriptionally distinct malignant neuroblastoma populations show selective response to adavosertib treatment., PMID:40118716
Cell Migration in Endometriosis Responds to Omentum-Derived Molecular Cues Similar to Ovarian Cancer., PMID:40076450
The Role of RAC2 and PTTG1 in Cancer Biology., PMID:40072059
RNA sequencing identifies MAP1A and PTTG1 as predictive genes of aging CD264+ human mesenchymal stem cells at an early passage., PMID:39980838
Biomarker Panels Associated with Diagnosis and Overall Survival in Hepatocellular Carcinoma Revealed from Protein-Protein and mRNA-miRNA Interaction Networks., PMID:39874008
Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells., PMID:39849583
Exploring potential key genes and pathways associatedwith hepatocellular carcinoma prognosis through bioinformatics analysis, followed by experimental validation., PMID:39822558
The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments., PMID:39792809
Association between transcription factors expression and growth patterns of nonfunctioning pituitary adenomas., PMID:39747515
Decoding the prognostic landscape of LUAD: the interplay between N6-methyladenosine modification and immune microenvironment., PMID:39720723
Comprehensive analysis of the pituitary tumor-transforming gene (PTTG) family in lung adenocarcinoma: diagnostic, prognostic, and therapeutic implications., PMID:39678599
Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1., PMID:39652418
The combination of serum lncRNA PTTG3P and mRNA PTTG1 serves as a diagnostic and prognostic marker for hepatocellular carcinoma., PMID:39635828
RNA Sequencing Reveals That the Genes Related to Cell Cycle and Glycolysis Play an Essential Role in IL-27-Induced Keratinocyte Hyperproliferation., PMID:39525318
Multi-omics analysis identifies PTTG1 as a prognostic biomarker associated with immunotherapy and chemotherapy resistance., PMID:39455949
Multi-omic analysis revealed the immunological patterns and diagnostic value of exhausted T cell-derived PTTG1 in patients with psoriasis., PMID:39342798
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia., PMID:39265882
Identification of Hub Genes in Comorbidity of Psoriasis and Vitiligo Using Bioinformatics Analysis., PMID:39258216
Therapeutic Potential of PLK1, KIF4A, CDCA5, UBE2C, CDT1, SKA3, AURKB, and PTTG1 Genes in Triple-Negative Breast Cancer: Correlating Their Expression with Sensitivity to GSK 461364 and IKK 16 Drugs., PMID:39214909
Pituitary tumor‑transforming gene 1 regulates the senescence and apoptosis of oral squamous cell carcinoma in a p21‑dependent DNA damage response manner., PMID:39155881
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model., PMID:39153120
MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte., PMID:39093409
KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells., PMID:38926398
IFIH1-mediated post-transcriptional regulation of PTTG1 promotes proliferation and affects PHA-848125 sensitivity and prognosis in oropharyngeal carcinoma., PMID:38859832
Combinatorial metabolomic and transcriptomic analysis of muscle growth in hybrid striped bass (female white bass Morone chrysops x male striped bass M. saxatilis)., PMID:38858615
SKA3/PTTG1/c-MYC signal loop drives the progression of colorectal cancer., PMID:38849978
Identification and Verification of Metabolism-related Immunotherapy Features and Prognosis in Lung Adenocarcinoma., PMID:38500277
Upregulated expression of PTTG1 is associated with progression of pancreatic cancer., PMID:38482253
Multi-Omics Analysis of the Oncogenic Value of Pituitary Tumor-Transforming Gene 1 (PTTG1) in Human Cancers., PMID:38420810
A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide., PMID:38124114
Novel 2 Gene Signatures Associated With Breast Cancer Proliferation: Insights From Predictive Differential Gene Expression Analysis., PMID:38104894
SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma., PMID:38069214
Transcriptome analysis of meiotic and post-meiotic spermatogenic cells reveals the potential hub genes of aging on the decline of male fertility., PMID:37839768
UBE2C serves as a prognosis biomarker of uterine corpus endometrial carcinoma via promoting tumor migration and invasion., PMID:37803076
Cancer Stem Cell Markers-Clinical Relevance and Prognostic Value in High-Grade Serous Ovarian Cancer (HGSOC) Based on The Cancer Genome Atlas Analysis., PMID:37628927
Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis., PMID:37583701
Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries., PMID:37460698
A novel investigation into an E2F transcription factor-related prognostic model with seven signatures for colon cancer patients., PMID:37431829
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity., PMID:37400529
Identification of several inflammation-related genes based on bioinformatics and experiments., PMID:37301122
PTTG1 Enhances Oncolytic Adenovirus 5 Entry into Pancreatic Adenocarcinoma Cells by Increasing CXADR Expression., PMID:37243239
Gene Expression Pattern of ESPL1, PTTG1 and PTTG1IP Can Potentially Predict Response to TKI First-Line Treatment of Patients with Newly Diagnosed CML., PMID:37174118
PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression., PMID:37159932
For research use only. Not for human or drug use.
