Catalog No.
YHK91801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser176-Gly330
Predicted molecular weight
18.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96S59
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RanBP7, RanBPM, RanBP9, Ran-binding protein 9, Ran-binding protein M, BPM90, RANBP9, BPM-L, RANBPM
Cloning, expression and purification of the low-complexity region of RanBP9 protein. PMID: 32217127
RANBP9 suppresses tumor proliferation in colorectal cancer. PMID: 30988811
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. PMID: 31795790
COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels. PMID: 23926111
Reduced RANBP9 expression is associated with poor prognosis in colorectal cancer patients. PMID: 35117028
Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells. PMID: 26943034
RANBP9 as potential therapeutic target in non-small cell lung cancer. PMID: 34778565
Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis. PMID: 23348590
RanBP9 overexpression reduces dendritic arbor and spine density. PMID: 24486966
Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. PMID: 22294787
Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration. PMID: 22361682
Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia. PMID: 25482375
Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes. PMID: 29016855
RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PMID: 23840553
Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development. PMID: 28359144
CLOCK interacts with RANBP9 and is involved in alternative splicing in spermatogenesis. PMID: 29126923
Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis. PMID: 34546853
Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. PMID: 19251705
Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly. PMID: 22223749
Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. PMID: 23982146
S100A7/Ran-binding protein 9 coevolution in mammals. PMID: 32043173
RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain. PMID: 24454876
RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. PMID: 23764848
A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons. PMID: 24592211
RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients. PMID: 30076413
Scorpins in the DNA Damage Response. PMID: 29914204
A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. PMID: 19729516
RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease. PMID: 24892886
RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60. PMID: 25024339
RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma. PMID: 28032865
A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. PMID: 14684163
RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain. PMID: 24254706
Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin. PMID: 32346083
Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation. PMID: 18710924
RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. PMID: 25741591
RanBP9 controls the oligomeric state of CTLH complex assemblies. PMID: 36621627
An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. PMID: 24509082
RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility. PMID: 25474150
Expression of cartilage antitumor component RanBP9 in osteosarcoma. PMID: 27049080
RanBPM, a scaffolding protein in the immune and nervous systems. PMID: 18040864
Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation. PMID: 20395553
RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. PMID: 27835883
The CTLH Complex in Cancer Cell Plasticity. PMID: 31885576
Correction: RanBP9 Overexpression Accelerates Loss of Pre and Postsynaptic Proteins in the APΔE9 Transgenic Mouse Brain. PMID: 30995273
Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. PMID: 36459484
Ran binding protein 9 interacts with Raf kinase but does not contribute to downstream ERK1/2 activation in skeletal myoblasts. PMID: 16364241
COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain. PMID: 25713139
Structural and Functional Insights into GID/CTLH E3 Ligase Complexes. PMID: 35682545
MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9. PMID: 32622424
[Multiadaptor 4.1 and RanBP9 protein family members as putative interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor]. PMID: 18318119
The CCDC55 couples cannabinoid receptor CNR1 to a putative DISC1 schizophrenia pathway. PMID: 26475744
Cell signalling pathway regulation by RanBPM: molecular insights and disease implications. PMID: 28659384
YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. PMID: 20580816
Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer's Disease. PMID: 31594228
Studies of recombinant TWA1 reveal constitutive dimerization. PMID: 27920276
Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids. PMID: 36012324
The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. PMID: 18579686
Genome-Wide RNAi Screen Identifies Regulators of Cardiomyocyte Necrosis. PMID: 32259070
The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. PMID: 15381419
Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. PMID: 12147692
Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. PMID: 33632744
The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. PMID: 15713673
Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex. PMID: 35833506
The human GID complex engages two independent modules for substrate recruitment. PMID: 34647674
Characterization of RanBPM molecular determinants that control its subcellular localization. PMID: 25659156
RanBPM associates with CD39 and modulates ecto-nucleotidase activity. PMID: 16478441
Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro. PMID: 28739732
Cognitive Decline and Modulation of Alzheimer's Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons. PMID: 32504417
Identifying and Validating Differentially Methylated Regions in Newly Diagnosed Patients with Graves' Disease. PMID: 33617351
Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. PMID: 24143168
Analysis of the gene expression profile of mouse male meiotic germ cells. PMID: 15053975
Effect of TERT and ATM on gene expression profiles in human fibroblasts. PMID: 14978791
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes. PMID: 19018242
For research use only. Not for human or drug use.
