IL-11 is a crucial determinant of cardiovascular fibrosis. PMID: 29160304
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. PMID: 33397952
Interleukin-11 drives human and mouse alcohol-related liver disease. PMID: 35365572
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis. PMID: 35408908
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. PMID: 36470928
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. PMID: 34108253
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. PMID: 31078624
Xenopus laevis il11ra.L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration. PMID: 35115663
Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications. PMID: 31794912
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues. PMID: 36012165
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome. PMID: 35135328
Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis. PMID: 24498618
CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma. PMID: 36238304
Interleukin-11. PMID: 7532057
Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. PMID: 9310465
IL11RA-related Crouzon-like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. PMID: 29926465
Evolution of the phenotype of craniosynostosis with dental anomalies syndrome and report of IL11RA variant population frequencies in a Crouzon-like autosomal recessive syndrome. PMID: 30811827
IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. PMID: 23631681
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice. PMID: 30956944
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury. PMID: 35806094
Associations between promoter polymorphism -106A/G of interleukin-11 receptor alpha and papillary thyroid cancer in Korean population. PMID: 21982075
A Novel Large Deletion Encompassing the Whole of the Galactose-1-Phosphate Uridyltransferase (GALT) Gene and Extending into the Adjacent Interleukin 11 Receptor Alpha (IL11RA) Gene Causes Classic Galactosemia Associated with Additional Phenotypic Abnormalities. PMID: 24002815
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption. PMID: 33940443
Interleukin-11 and its receptor. PMID: 1292471
Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines. PMID: 27920471
The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis. PMID: 35331937
IL-11 in cardiac and renal fibrosis: Late to the party but a central player. PMID: 32022251
Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis. PMID: 34447675
Update on development of interleukin-11. PMID: 9371993
Genes involved in implantation. PMID: 11545164
The biology of interleukin 11. PMID: 8401258
Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9. PMID: 32277509
The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping. PMID: 8786120
Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression. PMID: 9073505
Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. PMID: 8808281
Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice. PMID: 17881769
Critical Conditions for Studying Interleukin-11 Signaling In Vitro and Avoiding Experimental Artefacts. PMID: 34570432
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy. PMID: 32530750
Host IL11 Signaling Suppresses CD4+ T cell-Mediated Antitumor Responses to Colon Cancer in Mice. PMID: 33906864
Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. PMID: 19647472
Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice. PMID: 15537430
Cytokine pleiotropy and redundancy--gp130 cytokines in human implantation. PMID: 10098321
Genetic study of intracranial aneurysms. PMID: 25649796
Hyper-interleukin-11 novel designer molecular adjuvant targeting gp130 for whole cell cancer vaccines. PMID: 21995459
Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. PMID: 10482979
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome. PMID: 36924234
The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor. PMID: 11012177
IL-11: insights in asthma from overexpression transgenic modeling. PMID: 11590369
FLUOROFENIDONE ATTENUATES PULMONARY INFLAMMATION AND FIBROSIS BY INHIBITING THE IL-11/MEK/ERK SIGNALING PATHWAY. PMID: 36166195
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload. PMID: 33462828
IL-11 regulates autoimmune demyelination. PMID: 19734214
MEK/ERK/RUNX2 Pathway-Mediated IL-11 Autocrine Promotes the Activation of Müller Glial Cells during Diabetic Retinopathy. PMID: 36154781
The interleukin-11/receptor complex: rational design of agonists/antagonists and immunoassays potentially useful in human therapy. PMID: 9851534
Interleukin-11 classic but not trans-signaling is essential for fertility in mice. PMID: 28864002
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis. PMID: 36376885
Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. PMID: 21741611
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts. PMID: 34651016
[Interferon-related gene array in predicting the efficacy of interferon therapy in chronic hepatitis B]. PMID: 36854551
Modular organization of Interleukin-6 and Interleukin-11 α-receptors. PMID: 26551279
In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity. PMID: 34831321
miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11. PMID: 29901200
A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130. PMID: 10350068
Rare and low-frequency coding variants alter human adult height. PMID: 26743485
NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung. PMID: 26726132
Interleukin-11 binds specific EF-hand proteins via their conserved structural motifs. PMID: 34239012
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis. PMID: 30268501
Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice. PMID: 27884935
Diagnostic value of exome and whole genome sequencing in craniosynostosis. PMID: 8662918
Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. PMID: 36071494
Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing. PMID: 29792901
Identification and functional characterization, including cytokine production modulation, of the novel chicken Interleukin-11. PMID: 29523682
The length of the interleukin-11 receptor stalk determines its capacity for classic signaling. PMID: 15606508
Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization. PMID: 31403827
Interleukin-11 Overexpression and M2 Macrophage Density are Associated with Angiogenic Activity in Proliferative Diabetic Retinopathy. PMID: 29327326
IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells. PMID: 30967156
Immune profiling of pre- and post-treatment breast cancer tissues from the SWOG S0800 neoadjuvant trial. PMID: 32812178
Prognostication of a 13-immune-related-gene signature in patients with early triple-negative breast cancer. PMID: 15596233
Expression of interleukin-11 receptor alpha and interleukin-11 protein in the endometrium of normal fertile women and women with recurrent miscarriage. PMID: 34435951
The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. PMID: 23549086
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. PMID: 33590875
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts. PMID: 25832466
Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study. PMID: 23869192
Designer cytokine hyper interleukin 11 (H11) is a megakaryopoietic factor. PMID: 11161848
Interleukin-11 receptor expression in primary ovarian carcinomas. PMID: 25008910
Neurologic sequela in a patient with galactosemia potentially mediated by interleukin-11 dysfunction. PMID: 19144959
IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice. PMID: 12865319
Functional characterization of W147A: a high-affinity interleukin-11 antagonist. PMID: 34667238
A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model. PMID: 20393170
Differential endometrial gene expression in pregnant and nonpregnant sows. PMID: 27697725
Effects of beta-tricalcium phosphate particles on primary cultured murine dendritic cells and macrophages. PMID: 12919066
Characterization of a potent human interleukin-11 agonist. PMID: 28186993
Therapeutically blocking Interleukin-11 Receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours. PMID: 28698375
BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation. PMID: 32308549
miR-19 regulates the expression of interferon-induced genes and MHC class I genes in human cancer cells. PMID: 15081255
Immunologic variables in acute mania of bipolar disorder. PMID: 8549788
Interleukin-10 induces interleukin-11 responsiveness in human myeloma cell lines. PMID: 9572469
Suppression of interleukin-11-mediated bone resorption by cyclooxygenases inhibitors. PMID: 10725745
IL-11 activates human endothelial cells to resist immune-mediated injury. PMID: 28143986
Expression of Biomarkers CXCR4, IL11-RA, TFF1, MLF1P in Advanced Breast Cancer Patients with Bone Metastatic: a Diagnostic Study. PMID: 8809037
Mediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor. PMID: 31280266
Ubiquitin-Specific Protease 8 Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing. PMID: 9354656
Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro. PMID: 12569176
Expression and function of interleukin-11 and its receptor alpha in the human endometrium. PMID: 10948192
Interleukin-11 signals through the formation of a hexameric receptor complex. PMID: 8020567
Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor. PMID: 18076769
Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis. PMID: 26962683
IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. PMID: 10026196
Identification of three distinct receptor binding sites of murine interleukin-11. PMID: 28546923
Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells. PMID: 17175250
Enhancing engraftment of neonatal porcine xenoislet with CTLA4Ig and nordihydroguaiaretic acid. PMID: 8821584
Interleukin-11 (IL-11) and its receptor: biology and potential clinical applications in thrombocytopenic states. PMID: 30578761
Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor. PMID: 9166888
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. PMID: 11177577
Interleukin-11 modulates Th1/Th2 cytokine production from activated CD4+ T cells. PMID: 11350802
Interleukin-6 family cytokines: signaling and effects in human airway smooth muscle cells. PMID: 16614887
Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer. PMID: 9479504
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