Catalog No.
YHK91601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala383-Glu441
Predicted molecular weight
34.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q69YH5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Repo-Man, Recruits PP1 onto mitotic chromatin at anaphase protein, CDCA2, Cell division cycle-associated protein 2
CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma. PMID: 34103686
CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway. PMID: 36588796
Increased CDCA2 Level Was Related to Poor Prognosis in Hepatocellular Carcinoma and Associated With Up-Regulation of Immune Checkpoints. PMID: 35372372
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren's syndrome. PMID: 35958619
CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1. PMID: 32633378
The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma. PMID: 35386230
CDCA2 acts as an oncogene and induces proliferation of clear cell renal cell carcinoma cells. PMID: 32194746
CDCA2 promotes lung adenocarcinoma cell proliferation and predicts poor survival in lung adenocarcinoma patients. PMID: 28423619
CDCA2 triggers in vivo and in vitro proliferation of hepatocellular carcinoma by activating the AKT/CCND1 signaling. PMID: 34268949
CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo. PMID: 31196027
CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells. PMID: 34036376
CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway. PMID: 32509575
CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A. PMID: 37196484
Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner. PMID: 35694386
Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PMID: 23418564
Repo-man at the intersection of chromatin remodelling, DNA repair, nuclear envelope organization, and cancer progression. PMID: 24563358
Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma. PMID: 27733221
Bioinformatics analysis of the clinical relevance of CDCA gene family in prostate cancer. PMID: 35119046
Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation. PMID: 35414260
Repo-Man/PP1 regulates heterochromatin formation in interphase. PMID: 28091603
SUMOylation of RepoMan during late telophase regulates dephosphorylation of lamin A. PMID: 34387316
RepoMan stimulates the chromosome-dependent pathway of microtubule assembly. PMID: 33054506
Bioinformatics analysis identified hub genes in prostate cancer tumorigenesis and metastasis. PMID: 34198380
Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. PMID: 20188555
Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma. PMID: 33437202
Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells. PMID: 31967936
Expression of cell divisioncycle-associated genes and their prognostic significance in hepatocellular carcinoma. PMID: 33564348
Expanding the PP2A Interactome by Defining a B56-Specific SLiM. PMID: 27998540
Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs. PMID: 24905922
Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water. PMID: 28959563
Prognostic Analysis of Differentially Expressed DNA Damage Repair Genes in Bladder Cancer. PMID: 35685866
Detection of ligand-selective interactions of the human androgen receptor by SELDI-MS-TOF. PMID: 21796530
Hub Genes and Key Pathways of Intervertebral Disc Degeneration: Bioinformatics Analysis and Validation. PMID: 34545328
Aurora B regulates PP1γ-Repo-Man interactions to maintain the chromosome condensation state. PMID: 32938714
p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man. PMID: 29222185
Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase). PMID: 23362328
JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells. PMID: 25193078
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. PMID: 27572260
PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma. PMID: 37083601
Identification of a 5-Nutrient Stress-Sensitive Gene Signature to Predict Survival for Colorectal Cancer. PMID: 35496037
Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch. PMID: 26674376
Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA). PMID: 36632790
CDCA1/2/3/5/7/8 as novel prognostic biomarkers and CDCA4/6 as potential targets for gastric cancer. PMID: 35116645
Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins. PMID: 29764992
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. PMID: 21820363
PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. PMID: 21514157
Decitabine induces G2/M cell cycle arrest by suppressing p38/NF-κB signaling in human renal clear cell carcinoma. PMID: 26617834
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. PMID: 22801782
Genome-wide analysis of lncRNAs, miRNAs, and mRNAs forming a prognostic scoring system in esophageal squamous cell carcinoma. PMID: 32095316
MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors. PMID: 34131285
Genome-wide association study for host response to bovine leukemia virus in Holstein cows. PMID: 27269789
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. PMID: 16998479
Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. PMID: 16492807
Identification of methylation sites and signature genes with prognostic value for luminal breast cancer. PMID: 29642861
Ischemic post-conditioning partially reverses cell cycle reactivity following ischemia/reperfusion injury: a genome-wide survey. PMID: 23469856
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man. PMID: 23746640
Effect of Rho-Associated Kinase Inhibitor and Mesenchymal Stem Cell-Derived Conditioned Medium on Corneal Endothelial Cell Senescence and Proliferation. PMID: 34207965
Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. PMID: 23319690
Calcium Signaling Involvement in Cadmium-Induced Astrocyte Cytotoxicity and Cell Death Through Activation of MAPK and PI3K/Akt Signaling Pathways. PMID: 26248512
Dual strands of the miR-223 duplex (miR-223-5p and miR-223-3p) inhibit cancer cell aggressiveness: targeted genes are involved in bladder cancer pathogenesis. PMID: 29540855
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PMID: 17611626
For research use only. Not for human or drug use.
