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Recombinant Human CNN1 Protein, N-His-SUMO

Catalog #:   YHE89902 Specific References (97) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: P51911
Protein length: Gly13-Gly135
Overview

Catalog No.

YHE89902

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Gly13-Gly135

Predicted molecular weight

26.30 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P51911

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Basic calponin, Calponin-1, CNN1, Calponin H1, smooth muscle

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human CNN1 protein
References

miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathway. PMID: 31986487

CNN1 Represses Bladder Cancer Progression and Metabolic Reprogramming by Modulating HIF-1α Signaling Pathway. PMID: 35903683

Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification. PMID: 32564697

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. PMID: 31395745

The Mps1 kinase modulates the recruitment and activity of Cnn1(CENP-T) at Saccharomyces cerevisiae kinetochores. PMID: 25716979

[Expression of calponin-1 and its pathogenic role in systemic sclerosis]. PMID: 31068302

Calponin 1 increases cancer-associated fibroblasts-mediated matrix stiffness to promote chemoresistance in gastric cancer. PMID: 36423735

Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. PMID: 22561345

Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells. PMID: 26970176

The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T. PMID: 32679099

CALD1, CNN1, and TAGLN identified as potential prognostic molecular markers of bladder cancer by bioinformatics analysis. PMID: 30633156

Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation. PMID: 21817093

Expression and chromosomal mapping of the mouse smooth muscle calponin gene. PMID: 11252166

LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1. PMID: 33328585

Calponin1 inhibits dilated cardiomyopathy development in mice through the εPKC pathway. PMID: 24631115

Weighted gene co-expression network analysis identified MYL9 and CNN1 are associated with recurrence in colorectal cancer. PMID: 32127961

Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation. PMID: 23044709

Loss of smooth muscle calponin results in impaired blood vessel maturation in the tumor-host microenvironment. PMID: 17391313

Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity. PMID: 28457943

Identification of the Critical Site of Calponin 1 for Suppression of Ovarian Cancer Properties. PMID: 26504022

Identification of potential therapeutic intervening targets by in-silico analysis of nsSNPs in preterm birth-related genes. PMID: 36881567

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. PMID: 23334295

CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report. PMID: 25538209

The matricellular protein CCN1 regulates TNF-α induced vascular endothelial cell apoptosis. PMID: 25820828

Bridgin connects the outer kinetochore to centromeric chromatin. PMID: 33420015

CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore. PMID: 27524485

Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle. PMID: 32039481

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. PMID: 32034099

Study on the role and pharmacology of cuproptosis in gastric cancer. PMID: 37007099

On the biocompatibility of graphene oxide towards vascular smooth muscle cells. PMID: 33059341

Depletion of CCN1/CYR61 reduces triple-negative/basal-like breast cancer aggressiveness. PMID: 35261806

Direct proteomic mapping of Streptomyces Luteogriseus Strain 103 and cnn1 and insights into antibiotic biosynthesis. PMID: 16335944

Bioinformatic screening and identification of downregulated hub genes in adrenocortical carcinoma. PMID: 32765768

Identification of hub genes and pathways in bladder cancer using bioinformatics analysis. PMID: 35291419

T time for point centromeres. PMID: 22561349

Age-Related Alterations in the Testicular Proteome of a Non-Human Primate. PMID: 34074003

Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program. PMID: 23175675

Combined control of the fibroblast contractile program by YAP and TAZ. PMID: 34755530

CENP-T proteins are conserved centromere receptors of the Ndc80 complex. PMID: 22561346

Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression. PMID: 24904090

The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives. PMID: 12790776

Matrix stiffness regulates SMC functions via TGF-β signaling pathway. PMID: 31442697

Genetic Profiles Related to Pathogenesis in Sporadic Intracranial Aneurysm Patients. PMID: 31238169

DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice. PMID: 22511778

Mouse-to-mouse variation in maturation heterogeneity of smooth muscle cells. PMID: 29796562

Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium. PMID: 34502527

Induced differentiation of human gingival fibroblasts into VSMC-like cells. PMID: 28107746

Comprehensive analysis of biomarkers for prostate cancer based on weighted gene co-expression network analysis. PMID: 32243390

Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex. PMID: 32976599

A translational cellular model for the study of peritubular cells of the testis. PMID: 32449695

Application of iTRAQ Technology to Identify Differentially Expressed Proteins of Sauce Lamb Tripe with Different Secondary Pasteurization Treatments. PMID: 35454754

Impact of STAT1 polymorphisms on crizotinib-induced hepatotoxicity in ALK-positive non-small cell lung cancer patients. PMID: 33387041

RNA sequencing analyses in infants patients with coarctation of the aorta. PMID: 34425910

Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. PMID: 23751188

Pathogenic effect of a TGFBR1 mutation in a family with Loeys-Dietz syndrome. PMID: 31475485

Genome-wide identification of alternative splicing associated with histone deacetylase inhibitor in cutaneous T-cell lymphomas. PMID: 36147491

Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. PMID: 17161435

Biointerface topography regulates phenotypic switching and cell apoptosis in vascular smooth muscle cells. PMID: 32278550

Development and function of smooth muscle cells is modulated by Hic1 in mouse testis. PMID: 32554530

Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell. PMID: 35491127

Insulin receptor substrate 1(IRS1) is related with lymph node metastases and prognosis in esophageal squamous cell carcinoma. PMID: 35688292

Testosterone Rescues the De-Differentiation of Smooth Muscle Cells Through Serum Response Factor/Myocardin. PMID: 27861881

CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. PMID: 20368616

Epigenomic, Transcriptomic, and Protective Effect of Carotenoid Fucoxanthin in High Glucose-Induced Oxidative Stress in Mes13 Kidney Mesangial Cells. PMID: 33448797

[Bioinformatics-based identification of the key genes associated with prostate cancer]. PMID: 34914287

Combination of PD98059 and TGF-β1 Efficiently Differentiates Human Urine-Derived Stem Cells into Smooth Muscle Cells. PMID: 34638875

XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. PMID: 26315405

CYR61 Confers the Sensitivity to Aromatase Inhibitor Letrozole in ER Positive Breast Carcinoma. PMID: 27113745

miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival. PMID: 23637774

Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells. PMID: 30524301

MRNA and miRNA expression patterns associated to pathways linked to metal mixture health effects. PMID: 24080485

RUNX3 is up-regulated in abdominal aortic aneurysm and regulates the function of vascular smooth muscle cells by regulating TGF-β1. PMID: 34813022

Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. PMID: 30707993

Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview. PMID: 37047404

Phenotypic transition of corpus cavernosum smooth muscle cells subjected to hypoxia. PMID: 24913687

Defective NOTCH signalling drives smooth muscle cell death and differentiation in bicuspid aortic valve aortopathy. PMID: 30689881

Taxotere-induced elevated expression of IL8 in carcinoma-associated fibroblasts of breast invasive ductal cancer. PMID: 28454334

Identification of Hub Genes and Construction of a Transcriptional Regulatory Network Associated With Tumor Recurrence in Colorectal Cancer by Weighted Gene Co-expression Network Analysis. PMID: 33897765

Biophysical and chemical effects of fibrin on mesenchymal stromal cell gene expression. PMID: 20678460

Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues. PMID: 32565759

Aortic dissection is associated with reduced polycystin-1 expression, an abnormality that leads to increased ERK phosphorylation in vascular smooth muscle cells. PMID: 28076932

Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. PMID: 31927669

Adipose tissue-derived stromal cells' conditioned medium modulates endothelial-mesenchymal transition induced by IL-1β/TGF-β2 but does not restore endothelial function. PMID: 31468648

Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. PMID: 22681909

Characterization of a non-human primate model for the study of testicular peritubular cells-comparison with human testicular peritubular cells. PMID: 29846669

Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. PMID: 20146266

Effect of chronic THC administration in the reproductive organs of male mice, spermatozoa and in vitro fertilization. PMID: 30077641

Potential Role of Glycogen Synthase Kinase-3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells. PMID: 26129946

Uncovering the molecular mechanisms between heart failure and end-stage renal disease via a bioinformatics study. PMID: 36704339

Controlling mesenchymal stem cells differentiate into contractile smooth muscle cells on a TiO2 micro/nano interface: Towards benign pericytes environment for endothelialization. PMID: 27232304

Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. PMID: 21139803

Weighted Gene Co-expression Network Analysis Identifies FKBP11 as a Key Regulator in Acute Aortic Dissection through a NF-kB Dependent Pathway. PMID: 29255427

Identification of a Klf4-dependent upstream repressor region mediating transcriptional regulation of the myocardin gene in human smooth muscle cells. PMID: 24060351

Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective tissue growth factor expression by angiotensin II 1a and bradykinin B2 receptors in Rat1 fibroblasts. PMID: 16294326

Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. PMID: 16140947

Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells. PMID: 26673782

[Calcitonin gene-related peptide induces phenotypic transformation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction]. PMID: 22049796

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human CNN1 Protein, N-His-SUMO [YHE89902]
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