Catalog No.
YHJ49302
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp340-Gly406
Predicted molecular weight
19.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BRQ0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pygopus homolog 2, PYGO2
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis. PMID: 33643814
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. PMID: 32727463
PYGO2 as an independent diagnostic marker expressed in a majority of colorectal cancers. PMID: 31492088
Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway. PMID: 30279163
Increased Pygo2 expression in liver of patients with hepatitis B virus-related fibrosis. PMID: 26013055
Wnt/β-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members. PMID: 27647933
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. PMID: 29769196
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation. PMID: 26170450
Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice. PMID: 23334328
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression. PMID: 27811361
The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. PMID: 23637336
Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. PMID: 24982158
Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. PMID: 18614164
Pygo2 siRNA Inhibit the Growth and Increase Apoptosis of U251 Cell by Suppressing Histone H3K4 Trimethylation. PMID: 25869613
Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway. PMID: 26876203
Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. PMID: 23684539
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. PMID: 26345837
Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment. PMID: 26902498
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. PMID: 19487454
Overexpression of Pygo2 Increases Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Cardiomyocyte-like Cells. PMID: 31749426
Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. PMID: 17425782
Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2. PMID: 36404439
Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poor prognosis. PMID: 25545771
miR-516a-3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway. PMID: 31273950
Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer. PMID: 23865714
Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway. PMID: 35707871
Association of PYGO2 and EGFR in esophageal squamous cell carcinoma. PMID: 23456637
Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. PMID: 22186018
Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer. PMID: 36897957
Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer. PMID: 24348855
A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer. PMID: 32586983
[Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. PMID: 23732668
The role of Pygopus 2 in rat glioma cell growth. PMID: 20361361
Downregulation of Pygopus 2 inhibits vascular mimicry in glioma U251 cells by suppressing the canonical Wnt signaling pathway. PMID: 26870266
Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. PMID: 20937768
Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth. PMID: 20204459
TSF/FHA induces osteogenic differentiation of Mc3t3 cells via Pygo2 dependent Wnt/β-catenin signaling pathway. PMID: 37193170
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis. PMID: 34362407
A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. PMID: 22379092
A review on the role of SNHG8 in human disorders. PMID: 37043963
PYGOPUS2 expression in prostatic adenocarcinoma is a potential risk stratification marker for PSA progression following radical prostatectomy. PMID: 28924059
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. PMID: 17428831
Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector. PMID: 29719262
Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients. PMID: 36688188
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection. PMID: 19487452
Overexpression of Pygopus2 protects HeLa cells from vinblastine-induced apoptosis. PMID: 19040349
Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor. PMID: 20637214
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives. PMID: 25913844
Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2. PMID: 27324116
Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells. PMID: 28427190
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism. PMID: 33635162
A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. PMID: 28174279
The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein. PMID: 19555349
Contribution of KCTD12 to esophageal squamous cell carcinoma. PMID: 30157793
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. PMID: 16940750
Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. PMID: 28296634
Comparative genomics on FGF16 orthologs. PMID: 16211270
Evidence of a novel role for Pygopus in rRNA transcription. PMID: 23517060
Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression. PMID: 25871475
Requirement of Pygopus 2 in breast cancer. PMID: 17203217
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans. PMID: 27569725
Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling. PMID: 28815294
BCL9-2 promotes early stages of intestinal tumor progression. PMID: 21703997
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. PMID: 24605829
Lactobacillus species inhibitory effect on colorectal cancer progression through modulating the Wnt/β-catenin signaling pathway. PMID: 32419125
Selective estrogen receptor modulators and betulinic acid act synergistically to target ERα and SP1 transcription factor dependent Pygopus expression in breast cancer. PMID: 26645832
Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation. PMID: 25797263
Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development. PMID: 23955574
Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin. PMID: 18347063
Ibuprofen reduces cell proliferation through inhibiting Wnt/β catenin signaling pathway in gastric cancer stem cells. PMID: 29512256
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes. PMID: 33808143
A new nuclear component of the Wnt signalling pathway. PMID: 11988739
Oncogenic activation of the human Pygopus2 promoter by E74-like factor-1. PMID: 18314487
LncRNA625 modulates prostate cancer cells proliferation and apoptosis through regulating the Wnt/β-catenin pathway by targeting miR-432. PMID: 28678327
Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. PMID: 20514431
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. PMID: 11955446
Pygopus is required for embryonic brain patterning in Xenopus. PMID: 12941625
Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer. PMID: 16609037
Human papilloma virus (HPV) E7-mediated attenuation of retinoblastoma (Rb) induces hPygopus2 expression via Elf-1 in cervical cancer. PMID: 23284001
Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGFβ, Wnt, and Notch signaling. PMID: 23600707
Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer. PMID: 28055972
For research use only. Not for human or drug use.
