Catalog No.
YHF93802
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp264-Ser485
Predicted molecular weight
27.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02413
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DGI, Cadherin family member 4, Desmoglein-1, DG1, Pemphigus foliaceus antigen, CDHF4, DSG1, Desmosomal glycoprotein 1
Pemphigus. PMID: 31498102
Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin. PMID: 35711465
Decreased FABP5 and DSG1 protein expression following PAX6 knockdown of differentiated human limbal epithelial cells. PMID: 34954205
A DSG1 Frameshift Variant in a Rottweiler Dog with Footpad Hyperkeratosis. PMID: 32344723
Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma. PMID: 32850288
Bullous and verrucous lichen sclerosus with autoantibodies against both desmoglein Dsg1 and Dsg3. PMID: 34859893
Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations. PMID: 34657339
Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells? PMID: 34827649
Novel member of the mouse desmoglein gene family: Dsg1-beta. PMID: 12631242
Epidermal stratification requires retromer-mediated desmoglein-1 recycling. PMID: 36495876
Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus. PMID: 19571823
Expression of DSG1 and DSC1 are prognostic markers in anal carcinoma patients. PMID: 22333708
Novel mutation in the DSG1 gene causes autosomal-dominant striate palmoplantar keratoderma in a large Syrian family. PMID: 31192455
Loss-of-function mutation in DSG1 underlies focal palmoplantar keratoderma. PMID: 30451323
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion. PMID: 31178865
Pemphigus Foliaceus. PMID: 29763004
Deep-intronic and frameshift DSG1 variants associated with atypical severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome in a Chinese family. PMID: 33818390
Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function. PMID: 34458999
Novel nonsense variants in SLURP1 and DSG1 cause palmoplantar keratoderma in Pakistani families. PMID: 31443639
A novel homozygous frameshift mutation in DSG1 gene in an Indian consanguineous family with severe dermatitis, multiple allergies and metabolic wasting syndrome. PMID: 33666035
Pemphigus Vegetans. PMID: 31424813
Production of recombinant extracellular domains of canine desmoglein 1 (Dsg1) by baculovirus expression. PMID: 12963278
Autoantibody-Specific Signalling in Pemphigus. PMID: 34434944
Alterations in the interaction between GAL4 and GAL80 effect regulation of the yeast GAL regulon mediated by the F box protein Dsg1. PMID: 20135317
Novel mutations in DSG1 causing striate palmoplantar keratoderma. PMID: 19018793
Differential Pathomechanisms of Desmoglein 1 Transmembrane Domain Mutations in Skin Disease. PMID: 34352264
Acantholytic dyskeratotic epidermal naevus and striate palmoplantar keratoderma associated with DSG1 mutation: evidence for segmental type 2 mosaicism. PMID: 33539609
Striate palmoplantar keratoderma resulting from a missense mutation in DSG1. PMID: 29315490
Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. PMID: 34905516
Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. PMID: 8188687
Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. PMID: 8294446
Whole-exome sequencing identifies novel autosomal recessive DSG1 mutations associated with mild SAM syndrome. PMID: 26288349
The extracellular aminoterminal domain of bovine desmoglein 1 (Dsg1) is recognized only by certain pemphigus foliaceus sera, whereas its intracellular domain is recognized by both pemphigus vulgaris and pemphigus foliaceus sera. PMID: 8040606
Striate palmoplantar keratoderma: Report of a novel DSG1 mutation and atypical clinical manifestations. PMID: 26493105
The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. PMID: 15797387
Messages from Mutant Desmosomes. PMID: 34799122
The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12. PMID: 8034325
Autoimmune Pemphigus: Latest Advances and Emerging Therapies. PMID: 35187073
Unusual pemphigus phenotype in the presence of a Dsg1 and Dsg3 autoantibody profile. PMID: 11874500
Conformational epitopes of pemphigus antigens (Dsg1 and Dsg3) are calcium dependent and glycosylation independent. PMID: 7543549
Pruritic Blistering Eruption: Answer. PMID: 31990703
Pemphigus. PMID: 28492232
Pemphigus vegetans with antibodies against desmoglein 1 and desmocollin 1-3: a case report and literature review. PMID: 35829665
Desmoglein-1, differentiation, and disease. PMID: 23524961
Desmoglein 1 Deficiency Causes Lethal Skin Blistering. PMID: 30660666
Pemphigus herpetiformis with IgG autoantibodies to desmoglein 1 and desmocollin 1. PMID: 25244249
Autoantibodies against Desmoglein 1 and 3 in South Tunisian pemphigus. PMID: 35288901
Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling. PMID: 31563153
ELISA detection of anti-desmoglein 1 and anti-desmoglein 3 and indirect immunofluorescence in oral pemphigus: A retrospective study. PMID: 33721369
Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering. PMID: 30949721
Autoantibodies against desmoglein 2 are not pathogenic in pemphigus. PMID: 35058080
Multiple facets of desmoglein 1 mutations. PMID: 30222890
Serum levels of desmoglein-1 DNA copies in cell-free DNA of patients with pemphigus. PMID: 32974917
Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner. PMID: 30655320
Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin. PMID: 31781120
Inhibition of desmoglein-1 by aspirin leads to synthetic lethality of keratinocytes in Shuanghuanglian-induced cutaneous eruption response. PMID: 34126182
Anti-desmoglein 1 IgG/IgA pemphigus associated with thymoma. PMID: 29030953
Desmoglein as a target in skin disease and beyond. PMID: 22189787
The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome. PMID: 31465738
Trunk-dominant and classic facial pemphigus foliaceus in dogs - comparison of anti-desmocollin-1 and anti-desmoglein-1 autoantibodies and clinical presentations. PMID: 35670648
The value of desmoglein 1 and 3 antibody ELISA testing in patients with pemphigus. PMID: 19451505
Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. PMID: 23974871
Evaluation of Serum Desmoglein 1 and Desmoglein 3 in Oral Erosive Lichen Planus before and after Topical Application of Tacrolimus. PMID: 30498175
Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation. PMID: 23524970
Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane. PMID: 35634274
Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. PMID: 24220297
Epidermal Desmoglein 1 Expression Is Reduced in Kidney Transplant Recipients Compared with Immunocompetent Patients. PMID: 27302902
Epithelial barrier dysfunction in desmoglein-1 deficiency. PMID: 29705242
Pemphigus foliaceus. PMID: 18460886
Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis. PMID: 19546243
Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) with absence of desmoglein 1 and 3 antibodies: case report and literature review. PMID: 18092844
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission. PMID: 29145342
Desmoglein compensation hypothesis fidelity assessment in Pemphigus. PMID: 36211362
Anti-Desmoglein 1 and 3 Autoantibody Levels in Endemic Pemphigus Foliaceus and Pemphigus Vulgaris from Brazil. PMID: 28164651
Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus. PMID: 16293316
Detection of autoantibodies against recombinant desmoglein 1 and 3 molecules in patients with pemphigus vulgaris: correlation with disease extent at the time of diagnosis and during follow-up. PMID: 20049340
Pemphigus, a pathomechanism of acantholysis. PMID: 28211055
For research use only. Not for human or drug use.
