Catalog No.
YHJ71202
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr77-Gly171
Predicted molecular weight
23.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P0W2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HMGX2, BRAF35, HMG domain-containing protein HMGX2, HMG domain-containing protein 2, HMGXB2, Sox-like transcriptional factor, SMARCE1-related protein, HMG box-containing protein 20B, BRCA2-associated factor 35, HMG20B, Structural DNA-binding protein BRAF35, SMARCE1R, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. PMID: 21399666
HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block. PMID: 36171271
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis. PMID: 25486196
The DNA binding factor Hmg20b is a repressor of erythroid differentiation. PMID: 21606163
Investigation of hub genes involved in Turner syndrome using biological informatics methods. PMID: 35356930
HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition. PMID: 25639869
Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex. PMID: 30988160
HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. PMID: 10773667
Genome-Wide Analysis of Circular RNAs Mediated ceRNA Regulation in Porcine Embryonic Muscle Development. PMID: 31803743
The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation. PMID: 20530487
Dp71 Point Mutations Induce Protein Aggregation, Loss of Nuclear Lamina Integrity and Impaired Braf35 and Ibraf Function in Neuronal Cells. PMID: 36233175
Pharmacological inhibition of HDAC1/3-interacting proteins induced morphological changes, and hindered the cell proliferation and migration of hepatocellular carcinoma cells. PMID: 33929667
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma. PMID: 33026191
Hereditary breast and ovarian cancer genes. PMID: 12710679
CoREST-like complexes regulate chromatin modification and neuronal gene expression. PMID: 17085781
Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders. PMID: 12761041
Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. PMID: 12809554
Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. PMID: 16227968
Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome. PMID: 22818216
The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35. PMID: 28760657
Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35. PMID: 12083779
Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex. PMID: 22570500
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. PMID: 12032298
Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas. PMID: 12778069
Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens. PMID: 12083780
A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. PMID: 11207365
Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. PMID: 24227653
Characterization of human SMARCE1r high-mobility-group protein. PMID: 11997092
Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family. PMID: 10486208
Cell cycle. A complex twist for BRCA2. PMID: 11265239
Autonomously functioning thyroid nodules are not associated with BRAF mutations. PMID: 15009007
For research use only. Not for human or drug use.
