Catalog No.
YHF87402
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu20-Arg94
Predicted molecular weight
20.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01523
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HD5(20-94), DEF5, Defensin-5, DEFA5, Defensin, alpha 5
Protective Role of Spermidine in Colitis and Colon Carcinogenesis. PMID: 34767785
ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. PMID: 30452920
Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway. PMID: 34487729
Alpha-Defensin 5 Expression is Regulated by microRNAs in the Caco-2 Intestinal Epithelial Cell Line. PMID: 27525335
Identification of diagnostic signatures in ulcerative colitis patients via bioinformatic analysis integrated with machine learning. PMID: 34731452
The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1. PMID: 33503272
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PMID: 33690604
Defensin-driven viral evolution. PMID: 33232373
3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population. PMID: 36632813
Paneth's disease. PMID: 21122555
Identification of Epigenetic Methylation Signatures With Clinical Value in Crohn's Disease. PMID: 31663908
Electroacupuncture promoted intestinal defensins and rescued the dysbiotic cecal microbiota of high-fat diet-induced obese mice. PMID: 36116529
Human alpha defensin 5 expression in the human kidney and urinary tract. PMID: 22359618
Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. PMID: 18394979
Innate antimicrobial host defense in small intestinal Crohn's disease. PMID: 19850516
Differential effects of Staphylococcal enterotoxin B-mediated immune activation on intestinal defensins. PMID: 19386083
Fat-Shaped Microbiota Affects Lipid Metabolism, Liver Steatosis, and Intestinal Homeostasis in Mice Fed a Low-Protein Diet. PMID: 32579743
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease. PMID: 32351509
Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis. PMID: 29040430
Cell adhesion properties of human defensins. PMID: 29800568
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity. PMID: 32503648
Defensins versus bacteria: not just antibiotics anymore. PMID: 18486618
Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals. PMID: 21630271
Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease. PMID: 33017910
Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation. PMID: 34635074
Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins. PMID: 25517613
Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease. PMID: 32397546
Enteric defensins are essential regulators of intestinal microbial ecology. PMID: 19855381
Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2. PMID: 32437749
Human Enteric Defensin 5 Promotes Shigella Infection of Macrophages. PMID: 31611271
Immunology. Unraveling gut inflammation. PMID: 16931742
Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice. PMID: 32359121
[Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling]. PMID: 21634125
Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. PMID: 18305068
High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients. PMID: 32976188
Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples. PMID: 30004111
Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity. PMID: 19958093
Revealing the Achilles heel of bacterial toxins. PMID: 25517605
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. PMID: 18523026
Dynamics of human defensin 5 (HD5) self-assembly in solution: Molecular simulations/insights. PMID: 31349122
Evaluation of novel urinary tract infection biomarkers in children. PMID: 26885759
Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy. PMID: 33664853
Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study. PMID: 34830284
The penetration of human defensin 5 (HD5) through bacterial outer membrane: simulation studies. PMID: 34546425
Mechanism of adenovirus neutralization by Human alpha-defensins. PMID: 18191790
Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. PMID: 29858013
Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo. PMID: 31841560
Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. PMID: 25181039
Parasiticidal activity of human alpha-defensin-5 against Toxoplasma gondii. PMID: 20135360
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. PMID: 30808760
Human Paneth cell α-defensin-5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice. PMID: 30860877
Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide. PMID: 23841778
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin. PMID: 33518681
An optimized Fmoc synthesis of human defensin 5. PMID: 24311274
Functional intersection of Human Defensin 5 with the TNF receptor pathway. PMID: 24681099
Human alpha-defensins inhibit Clostridium difficile toxin B. PMID: 18435932
Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis. PMID: 31211760
A bacterial mutant library as a tool to study the attack of a defensin peptide. PMID: 25430675
Integrin and defensin modulate the mechanical properties of adenovirus. PMID: 23269786
HD5 and HBD1 variants' solvation potential energy correlates with their antibacterial activity against Escherichia coli. PMID: 26567133
Expression and structure/function relationships of human defensin 5. PMID: 22354633
Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease. PMID: 19266573
Regulation of human enteric α-defensins by NOD2 in the Paneth cell lineage. PMID: 25433720
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study. PMID: 34105106
Defensins' offensive play: exploiting a viral achilles' heel. PMID: 18191786
An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease. PMID: 32086815
The adsorption of human defensin 5 on bacterial membranes: simulation studies. PMID: 30187138
Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy. PMID: 32089753
Conformational landscape and pathway of disulfide bond reduction of human alpha defensin. PMID: 25970658
Resveratrol Improves Growth Performance, Intestinal Morphology, and Microbiota Composition and Metabolism in Mice. PMID: 34539617
Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. PMID: 21910169
A role for antimicrobial peptides in intestinal microsporidiosis. PMID: 19079820
Self-Assembling Myristoylated Human α-Defensin 5 as a Next-Generation Nanobiotics Potentiates Therapeutic Efficacy in Bacterial Infection. PMID: 29856606
Suppression of antimicrobial peptide expression by ureaplasma species. PMID: 24491573
Elucidating the Bacterial Membrane Disruption Mechanism of Human α-Defensin 5: A Theoretical Study. PMID: 28067516
Copy number polymorphisms are not a common feature of innate immune genes. PMID: 16617005
Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. PMID: 11181568
Visualizing attack of Escherichia coli by the antimicrobial peptide human defensin 5. PMID: 25664683
Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection. PMID: 25540379
Production of bioactive human alpha-defensin 5 in Pichia pastoris. PMID: 19940385
Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins. PMID: 27581352
Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity. PMID: 28850095
Defensin carriers for better mucosal immunity in the digestive system. PMID: 20438821
Prognostic and predictive potential molecular biomarkers in colon cancer. PMID: 21696062
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PMID: 28817680
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach. PMID: 31981594
Multivalent binding of carbohydrates by the human alpha-defensin, HD5. PMID: 19542459
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine. PMID: 30389960
Immunoprotective effect of epigallocatechin-3-gallate on oral anticancer drug-induced α-defensin reduction in Caco-2 cells. PMID: 24583869
Design of a potent antibiotic peptide based on the active region of human defensin 5. PMID: 25782105
Critical determinants of human α-defensin 5 activity against non-enveloped viruses. PMID: 22637473
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation. PMID: 36341397
Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection. PMID: 20130047
Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease. PMID: 19904243
For research use only. Not for human or drug use.
