Protective Role of Spermidine in Colitis and Colon Carcinogenesis. PMID: 34767785
ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. PMID: 30452920
Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway. PMID: 34487729
Alpha-Defensin 5 Expression is Regulated by microRNAs in the Caco-2 Intestinal Epithelial Cell Line. PMID: 27525335
Identification of diagnostic signatures in ulcerative colitis patients via bioinformatic analysis integrated with machine learning. PMID: 34731452
The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1. PMID: 33503272
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PMID: 33690604
Defensin-driven viral evolution. PMID: 33232373
3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population. PMID: 36632813
Paneth's disease. PMID: 21122555
Identification of Epigenetic Methylation Signatures With Clinical Value in Crohn's Disease. PMID: 31663908
Electroacupuncture promoted intestinal defensins and rescued the dysbiotic cecal microbiota of high-fat diet-induced obese mice. PMID: 36116529
Human alpha defensin 5 expression in the human kidney and urinary tract. PMID: 22359618
Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. PMID: 18394979
Innate antimicrobial host defense in small intestinal Crohn's disease. PMID: 19850516
Differential effects of Staphylococcal enterotoxin B-mediated immune activation on intestinal defensins. PMID: 19386083
Fat-Shaped Microbiota Affects Lipid Metabolism, Liver Steatosis, and Intestinal Homeostasis in Mice Fed a Low-Protein Diet. PMID: 32579743
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease. PMID: 32351509
Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis. PMID: 29040430
Cell adhesion properties of human defensins. PMID: 29800568
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity. PMID: 32503648
Defensins versus bacteria: not just antibiotics anymore. PMID: 18486618
Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals. PMID: 21630271
Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease. PMID: 33017910
Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation. PMID: 34635074
Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins. PMID: 25517613
Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease. PMID: 32397546
Enteric defensins are essential regulators of intestinal microbial ecology. PMID: 19855381
Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2. PMID: 32437749
Human Enteric Defensin 5 Promotes Shigella Infection of Macrophages. PMID: 31611271
Immunology. Unraveling gut inflammation. PMID: 16931742
Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice. PMID: 32359121
[Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling]. PMID: 21634125
Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. PMID: 18305068
High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients. PMID: 32976188
Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples. PMID: 30004111
Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity. PMID: 19958093
Revealing the Achilles heel of bacterial toxins. PMID: 25517605
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. PMID: 18523026
Dynamics of human defensin 5 (HD5) self-assembly in solution: Molecular simulations/insights. PMID: 31349122
Evaluation of novel urinary tract infection biomarkers in children. PMID: 26885759
Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy. PMID: 33664853
Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study. PMID: 34830284
The penetration of human defensin 5 (HD5) through bacterial outer membrane: simulation studies. PMID: 34546425
Mechanism of adenovirus neutralization by Human alpha-defensins. PMID: 18191790
Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. PMID: 29858013
Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo. PMID: 31841560
Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. PMID: 25181039
Parasiticidal activity of human alpha-defensin-5 against Toxoplasma gondii. PMID: 20135360
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. PMID: 30808760
Human Paneth cell α-defensin-5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice. PMID: 30860877
Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide. PMID: 23841778
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin. PMID: 33518681
An optimized Fmoc synthesis of human defensin 5. PMID: 24311274
Functional intersection of Human Defensin 5 with the TNF receptor pathway. PMID: 24681099
Human alpha-defensins inhibit Clostridium difficile toxin B. PMID: 18435932
Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis. PMID: 31211760
A bacterial mutant library as a tool to study the attack of a defensin peptide. PMID: 25430675
Integrin and defensin modulate the mechanical properties of adenovirus. PMID: 23269786
HD5 and HBD1 variants' solvation potential energy correlates with their antibacterial activity against Escherichia coli. PMID: 26567133
Expression and structure/function relationships of human defensin 5. PMID: 22354633
Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease. PMID: 19266573
Regulation of human enteric α-defensins by NOD2 in the Paneth cell lineage. PMID: 25433720
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study. PMID: 34105106
Defensins' offensive play: exploiting a viral achilles' heel. PMID: 18191786
An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease. PMID: 32086815
The adsorption of human defensin 5 on bacterial membranes: simulation studies. PMID: 30187138
Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy. PMID: 32089753
Conformational landscape and pathway of disulfide bond reduction of human alpha defensin. PMID: 25970658
Resveratrol Improves Growth Performance, Intestinal Morphology, and Microbiota Composition and Metabolism in Mice. PMID: 34539617
Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. PMID: 21910169
A role for antimicrobial peptides in intestinal microsporidiosis. PMID: 19079820
Self-Assembling Myristoylated Human α-Defensin 5 as a Next-Generation Nanobiotics Potentiates Therapeutic Efficacy in Bacterial Infection. PMID: 29856606
Suppression of antimicrobial peptide expression by ureaplasma species. PMID: 24491573
Elucidating the Bacterial Membrane Disruption Mechanism of Human α-Defensin 5: A Theoretical Study. PMID: 28067516
Copy number polymorphisms are not a common feature of innate immune genes. PMID: 16617005
Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. PMID: 11181568
Visualizing attack of Escherichia coli by the antimicrobial peptide human defensin 5. PMID: 25664683
Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection. PMID: 25540379
Production of bioactive human alpha-defensin 5 in Pichia pastoris. PMID: 19940385
Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins. PMID: 27581352
Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity. PMID: 28850095
Defensin carriers for better mucosal immunity in the digestive system. PMID: 20438821
Prognostic and predictive potential molecular biomarkers in colon cancer. PMID: 21696062
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PMID: 28817680
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach. PMID: 31981594
Multivalent binding of carbohydrates by the human alpha-defensin, HD5. PMID: 19542459
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine. PMID: 30389960
Immunoprotective effect of epigallocatechin-3-gallate on oral anticancer drug-induced α-defensin reduction in Caco-2 cells. PMID: 24583869
Design of a potent antibiotic peptide based on the active region of human defensin 5. PMID: 25782105
Critical determinants of human α-defensin 5 activity against non-enveloped viruses. PMID: 22637473
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation. PMID: 36341397
Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection. PMID: 20130047
Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease. PMID: 19904243
Identification and Validation of Key Genes Involved in the Coupling of Mitochondria-Associated Endoplasmic Reticulum Membrane in Hemorrhoidal Disease., PMID:40469970
Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and Pathways for Alzheimer's Disease., PMID:40166037
Activating Thermoplastic Polyurethane Surfaces with Poly(ethylene glycol)-Based Recombinant Human α-Defensin 5 Monolayers for Antibiofilm Activity., PMID:39977277
Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11., PMID:39901059
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues., PMID:39883179
Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples., PMID:39738327
Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses., PMID:39386684
Establishment of an in-vitro inflammatory bowel disease model using immunological differentiation of Caco-2 cells., PMID:39329151
Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection., PMID:39324144
Anti-DEFA5 Monoclonal Antibody Clones 1A8 and 4F5 Immunoreactive Bioassay for Diagnosing Inflammatory Bowel Disease., PMID:39257990
Innate Immunity Activation in Newly Diagnosed Ileocolonic Crohn's Disease: A Cohort Study., PMID:38319717
Regulation of Chloride Channels by Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced α-Defensin 5., PMID:38171775
Application of enzyme-linked immunosorbent assay to detect antimicrobial peptides in human intestinal lumen., PMID:38081407
FOXO inhibition rescues α-defensin expression in human intestinal organoids., PMID:37956278
The Function and Modification of Human Defensin 5., PMID:37861034
Ubiquitous Colonic Ileal Metaplasia Consistent with the Diagnosis of Crohn's Colitis among Indeterminate Colitis Cohorts., PMID:37854669
Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet., PMID:37762180
Reduced DEFA5 Expression and STAT3 Activation Underlie the Submucosal Invasion of Early Gastric Cancers., PMID:37598668
Predicting Duodenal Cancer Risk in Patients with Familial Adenomatous Polyposis Using Machine Learning Model., PMID:37565794
Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western-style diet., PMID:37246491
Integrated multiple microarray studies by robust rank aggregation to identify immune-associated biomarkers in Crohn's disease based on three machine learning methods., PMID:36792688
3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population., PMID:36632813
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation., PMID:36341397
Electroacupuncture promoted intestinal defensins and rescued the dysbiotic cecal microbiota of high-fat diet-induced obese mice., PMID:36116529
Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study., PMID:34830284
Protective Role of Spermidine in Colitis and Colon Carcinogenesis., PMID:34767785
Identification of diagnostic signatures in ulcerative colitis patients via bioinformatic analysis integrated with machine learning., PMID:34731452
Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation., PMID:34635074
The penetration of human defensin 5 (HD5) through bacterial outer membrane: simulation studies., PMID:34546425
Resveratrol Improves Growth Performance, Intestinal Morphology, and Microbiota Composition and Metabolism in Mice., PMID:34539617
Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway., PMID:34487729
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study., PMID:34105106
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease., PMID:33690604
Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy., PMID:33664853
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin., PMID:33518681
Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway., PMID:33505592
The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1., PMID:33503272
Defensin-driven viral evolution., PMID:33232373
Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease., PMID:33017910
High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients., PMID:32976188
Fat-Shaped Microbiota Affects Lipid Metabolism, Liver Steatosis, and Intestinal Homeostasis in Mice Fed a Low-Protein Diet., PMID:32579743
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity., PMID:32503648
Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2., PMID:32437749
Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease., PMID:32397546
Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice., PMID:32359121
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease., PMID:32351509
Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy., PMID:32089753
An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease., PMID:32086815
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach., PMID:31981594
Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo., PMID:31841560
For research use only. Not for human or drug use.
