Catalog No.
YHA63802
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln373-Gly579
Predicted molecular weight
25.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43306
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Adenylate cyclase type 6, KIAA0422, ATP pyrophosphate-lyase 6, ADCY6, Adenylyl cyclase 6, Ca(2+)-inhibitable adenylyl cyclase, Adenylate cyclase type VI
Purβ promotes hepatic glucose production by increasing Adcy6 transcription. PMID: 31918924
Phenotypic spectrum and genomics of undiagnosed arthrogryposis multiplex congenita. PMID: 33820833
Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects. PMID: 24319099
Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules. PMID: 33622336
Gene expression and DNA methylation analyses suggest that immune process-related ADCY6 is a prognostic factor of luminal-like breast cancer. PMID: 31886586
Circ-HIPK3 Strengthens the Effects of Adrenaline in Heart Failure by MiR-17-3p - ADCY6 Axis. PMID: 31595165
Decreased microRNA-182-5p helps alendronate promote osteoblast proliferation and differentiation in osteoporosis via the Rap1/MAPK pathway. PMID: 30413613
Knockdown of GPSM1 Inhibits the Proliferation and Promotes the Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway. PMID: 34257610
Candidate methylated genes in osteoarthritis explored by bioinformatics analysis. PMID: 27810435
Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6. PMID: 20732959
Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6. PMID: 17916776
beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. PMID: 18324973
Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia. PMID: 27067484
Expanding the clinical and molecular spectrum of lethal congenital contracture syndrome 8 associated with biallelic variants of ADCY6. PMID: 31846058
Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina. PMID: 37127773
Identification of a dysfunctional missense single nucleotide variant of human adenylyl cyclase VI. PMID: 15903125
Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family. PMID: 30647127
STIM1 activation of adenylyl cyclase 6 connects Ca2+ and cAMP signaling during melanogenesis. PMID: 29311116
Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells. PMID: 31512989
Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema. PMID: 29443612
Affection of Comt1 genetype on anxiety and nociceptive sensitivity: an Ego-network analysis approach. PMID: 28969474
Ciliary adenylyl cyclases control the Hedgehog pathway. PMID: 26092933
RNA Sequencing Uncovers Molecular Mechanisms Underlying Pathological Complete Response to Chemotherapy in Patients with Operable Breast Cancer. PMID: 28880852
Integration analysis of metabolome and transcriptome reveals the effect of exogenous supplementation with mixtures of vitamins ADE, zinc, and selenium on follicular growth and granulosa cells molecular metabolism in donkeys (Equus asinus). PMID: 36387403
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. PMID: 31494281
Systems genetics analysis defines importance of TMEM43/LUMA for cardiac- and metabolic-related pathways. PMID: 34766515
Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. PMID: 7766992
miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. PMID: 26888314
MicroRNA Dysregulation in the Hippocampus of Rats with Noise-Induced Hearing Loss. PMID: 34527169
Ovarian superstimulation using FSH combined with equine chorionic gonadotropin (eCG) upregulates mRNA-encoding proteins involved with LH receptor intracellular signaling in granulosa cells from Nelore cows. PMID: 25219847
Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq". PMID: 36706832
Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease. PMID: 24158982
Genome-wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders. PMID: 32108986
Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy. PMID: 31114845
Identification of high expression profiles of miR-31-5p and its vital role in lung squamous cell carcinoma: a survey based on qRT-PCR and bioinformatics analysis. PMID: 35116817
Hypoxia inhibits adenylyl cyclase catalytic activity in a porcine model of persistent pulmonary hypertension of the newborn. PMID: 30234376
Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. PMID: 19212623
Identification of transcription factors (TFs) and targets involved in the cholangiocarcinoma (CCA) by integrated analysis. PMID: 27857060
DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population. PMID: 28888730
Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. PMID: 23020224
Integrative analysis of methylome and transcriptome variation of identified cardiac disease-specific genes in human cardiomyocytes after PM2.5 exposure. PMID: 30286548
Effect of nitric oxide on the cyclic guanosine monophosphate (cGMP) pathway during meiosis resumption in bovine oocytes. PMID: 24331454
MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. PMID: 17597072
Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. PMID: 20656788
For research use only. Not for human or drug use.
