Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. PMID: 29400692
Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. PMID: 34848368
The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint. PMID: 32554797
Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. PMID: 23615913
IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling. PMID: 21401320
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. PMID: 23775122
Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation. PMID: 25830382
The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina. PMID: 33798691
YAP-TEAD up-regulates IRS2 expression to induce and deteriorate oesophageal cancer. PMID: 33570213
Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice. PMID: 23702782
4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass. PMID: 27217487
The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation. PMID: 27330190
On the role of IRS2 in the regulation of functional beta-cell mass. PMID: 16931448
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. PMID: 14693698
PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin. PMID: 30770439
IRS2 depletion inhibits cell proliferation and decreases hormone secretion in mouse granulosa cells. PMID: 29998910
IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes. PMID: 26384875
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. PMID: 30451856
MiRNA-7b-5p attenuates the progression of osteoporosis by inhibiting adipose differentiation of hMSCs via regulating IRS2. PMID: 31773671
Irs2 inactivation suppresses tumor progression in Pten+/- mice. PMID: 19095950
Altered expression of IRS2 and GRB2 in demyelination of peripheral neurons: Implications in diabetic neuropathy. PMID: 28065675
miR-431 regulates granulosa cell function through the IRS2/PI3K/AKT signaling pathway. PMID: 32051352
Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation. PMID: 36177037
Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter. PMID: 19875459
New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas. PMID: 36509718
The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions. PMID: 34189964
Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2. PMID: 24977713
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. PMID: 22560222
Expression of IRS2 in the female reproductive system during the estrous cycle in mice. PMID: 36472073
Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein. PMID: 21301804
miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway. PMID: 36833456
IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines. PMID: 25527633
Structural insights into suppressor of cytokine signaling 1 protein- identification of new leads for type 2 diabetes mellitus. PMID: 29630758
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. PMID: 22160220
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. PMID: 32015092
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. PMID: 23901139
Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet. PMID: 26976654
BH3-only molecule Bim mediates β-cell death in IRS2 deficiency. PMID: 24760140
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. PMID: 21926467
The double life of Irs. PMID: 18590687
IRS2 signalling is required for the development of a subset of sensory spinal neurons. PMID: 22288475
Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? PMID: 20604929
Function of PTB domains. PMID: 9401201
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. PMID: 12869553
The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. PMID: 18057093
Diabetes outfoxed by GLP-1? PMID: 15671479
Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue. PMID: 36246878
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. PMID: 19523444
Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2. PMID: 29685905
IRS-2 and its involvement in diabetes and aging. PMID: 19251045
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. PMID: 16272563
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport. PMID: 26491696
Insulin receptor substrate proteins and diabetes. PMID: 15180298
PDK-1 mediated Hippo-YAP-IRS2 signaling pathway and involved in the apoptosis of non-small cell lung cancer cells. PMID: 30988063
Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes. PMID: 25460042
Hepatocytes: critical for glucose homeostasis. PMID: 15061128
Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice. PMID: 25361392
Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus. PMID: 26999420
The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells. PMID: 29483197
Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice. PMID: 22210743
DYRK1A aggravates β cell dysfunction and apoptosis by promoting the phosphorylation and degradation of IRS2. PMID: 31306739
Pdx1 restores beta cell function in Irs2 knockout mice. PMID: 11994408
Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice. PMID: 34440853
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. PMID: 20028942
IRS proteins and beta-cell function. PMID: 11272176
Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. PMID: 24159000
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. PMID: 15572028
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. PMID: 16916938
Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs. PMID: 30295821
Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo. PMID: 28424159
Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and glutamine or glucose deprivation. PMID: 23363253
Brain IRS2 signaling coordinates life span and nutrient homeostasis. PMID: 17641201
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? PMID: 15271644
Calcineurin signaling regulates human islet {beta}-cell survival. PMID: 20943662
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. PMID: 21984580
Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. PMID: 29721854
Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation. PMID: 29411439
Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling. PMID: 18802016
Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling. PMID: 27457910
[Hypoxia promotes erythroid differentiation of human K562 cells by upregulating endothelial PAS domain-containing protein 1 (EPAS1) expression]. PMID: 35732606
Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1, NFI binding and ERK activation in HepG2 cells. PMID: 19755487
Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice. PMID: 22493491
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells. PMID: 20685959
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. PMID: 12228220
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. PMID: 9312143
Insulin Signaling Via Progesterone-Regulated Insulin Receptor Substrate 2 is Critical for Human Uterine Decidualization. PMID: 31748790
New findings in gene knockout, mutant and transgenic mice. PMID: 18053667
IRS2 takes center stage in the development of type 2 diabetes. PMID: 15467824
The insulin signalling system and the IRS proteins. PMID: 9248696
Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. PMID: 17127239
Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. PMID: 19933838
Insulin receptor substrate proteins and neuroendocrine function. PMID: 11498021
[Physical activity--genotype interaction]. PMID: 11085094
Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats. PMID: 25036495
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