Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. PMID: 29400692
Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. PMID: 34848368
The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint. PMID: 32554797
Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. PMID: 23615913
IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling. PMID: 21401320
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. PMID: 23775122
Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation. PMID: 25830382
The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina. PMID: 33798691
YAP-TEAD up-regulates IRS2 expression to induce and deteriorate oesophageal cancer. PMID: 33570213
Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice. PMID: 23702782
4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass. PMID: 27217487
The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation. PMID: 27330190
On the role of IRS2 in the regulation of functional beta-cell mass. PMID: 16931448
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. PMID: 14693698
PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin. PMID: 30770439
IRS2 depletion inhibits cell proliferation and decreases hormone secretion in mouse granulosa cells. PMID: 29998910
IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes. PMID: 26384875
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. PMID: 30451856
MiRNA-7b-5p attenuates the progression of osteoporosis by inhibiting adipose differentiation of hMSCs via regulating IRS2. PMID: 31773671
Irs2 inactivation suppresses tumor progression in Pten+/- mice. PMID: 19095950
Altered expression of IRS2 and GRB2 in demyelination of peripheral neurons: Implications in diabetic neuropathy. PMID: 28065675
miR-431 regulates granulosa cell function through the IRS2/PI3K/AKT signaling pathway. PMID: 32051352
Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation. PMID: 36177037
Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter. PMID: 19875459
New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas. PMID: 36509718
The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions. PMID: 34189964
Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2. PMID: 24977713
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. PMID: 22560222
Expression of IRS2 in the female reproductive system during the estrous cycle in mice. PMID: 36472073
Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein. PMID: 21301804
miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway. PMID: 36833456
IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines. PMID: 25527633
Structural insights into suppressor of cytokine signaling 1 protein- identification of new leads for type 2 diabetes mellitus. PMID: 29630758
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. PMID: 22160220
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. PMID: 32015092
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. PMID: 23901139
Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet. PMID: 26976654
BH3-only molecule Bim mediates β-cell death in IRS2 deficiency. PMID: 24760140
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. PMID: 21926467
The double life of Irs. PMID: 18590687
IRS2 signalling is required for the development of a subset of sensory spinal neurons. PMID: 22288475
Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? PMID: 20604929
Function of PTB domains. PMID: 9401201
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. PMID: 12869553
The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. PMID: 18057093
Diabetes outfoxed by GLP-1? PMID: 15671479
Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue. PMID: 36246878
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. PMID: 19523444
Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2. PMID: 29685905
IRS-2 and its involvement in diabetes and aging. PMID: 19251045
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. PMID: 16272563
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport. PMID: 26491696
Insulin receptor substrate proteins and diabetes. PMID: 15180298
PDK-1 mediated Hippo-YAP-IRS2 signaling pathway and involved in the apoptosis of non-small cell lung cancer cells. PMID: 30988063
Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes. PMID: 25460042
Hepatocytes: critical for glucose homeostasis. PMID: 15061128
Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice. PMID: 25361392
Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus. PMID: 26999420
The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells. PMID: 29483197
Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice. PMID: 22210743
DYRK1A aggravates β cell dysfunction and apoptosis by promoting the phosphorylation and degradation of IRS2. PMID: 31306739
Pdx1 restores beta cell function in Irs2 knockout mice. PMID: 11994408
Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice. PMID: 34440853
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. PMID: 20028942
IRS proteins and beta-cell function. PMID: 11272176
Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. PMID: 24159000
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. PMID: 15572028
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. PMID: 16916938
Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs. PMID: 30295821
Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo. PMID: 28424159
Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and glutamine or glucose deprivation. PMID: 23363253
Brain IRS2 signaling coordinates life span and nutrient homeostasis. PMID: 17641201
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? PMID: 15271644
Calcineurin signaling regulates human islet {beta}-cell survival. PMID: 20943662
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. PMID: 21984580
Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. PMID: 29721854
Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation. PMID: 29411439
Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling. PMID: 18802016
Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling. PMID: 27457910
[Hypoxia promotes erythroid differentiation of human K562 cells by upregulating endothelial PAS domain-containing protein 1 (EPAS1) expression]. PMID: 35732606
Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1, NFI binding and ERK activation in HepG2 cells. PMID: 19755487
Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice. PMID: 22493491
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells. PMID: 20685959
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. PMID: 12228220
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. PMID: 9312143
Insulin Signaling Via Progesterone-Regulated Insulin Receptor Substrate 2 is Critical for Human Uterine Decidualization. PMID: 31748790
New findings in gene knockout, mutant and transgenic mice. PMID: 18053667
IRS2 takes center stage in the development of type 2 diabetes. PMID: 15467824
The insulin signalling system and the IRS proteins. PMID: 9248696
Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. PMID: 17127239
Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. PMID: 19933838
Insulin receptor substrate proteins and neuroendocrine function. PMID: 11498021
[Physical activity--genotype interaction]. PMID: 11085094
Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats. PMID: 25036495
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway., PMID:40473822
The Effect of Tff3 Deficiency on the Liver of Mice Exposed to a High-Fat Diet., PMID:40426854
The Hypoglycemic Activity of Gracilaria lemaneiformis Polysaccharide Gels Based on IR/IRS-2/PI3k/Akt/Glut4 and Glycometabolism Signaling Pathways in HepG2 Cells., PMID:40422385
The Effect and Mechanism of Regular Exercise on Improving Insulin Impedance: Based on the Perspective of Cellular and Molecular Levels., PMID:40362436
Gan-tang-yi decoction improves hepatic insulin resistance through activation of IRS2/PI3K/Akt pathway and inhibition of AGEs/RAGE pathway in cirrhotic rats., PMID:40345270
Chronic intermittent hypoxia affects the expression of IRS - 2/p - Akt/GSK - 3 in the liver of SD rats and its impact on glucose metabolism., PMID:40342065
A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells., PMID:40285526
Exploration of the shared gene signatures and molecular mechanisms between cardioembolic stroke and ischemic stroke., PMID:40264650
Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease., PMID:40257057
Transcriptional Response to Fasting Studied in the Liver of Mice That Express Phosphorylation Resistant Perilipin 5., PMID:40238664
Hypoglycemic and Gut Microbiota-Modulating Effects of Pectin from Citrus aurantium "Changshanhuyou" Residue in Type 2 Diabetes Mellitus Mice., PMID:40191895
Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study., PMID:40179269
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction., PMID:40178645
Methylglyoxal-induced neuronal dysfunction: Linking diabetes to Alzheimer's disease through cytoskeletal disruption., PMID:40107340
IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological Conditions., PMID:40105689
Long non-coding RNA LINC01232 promotes malignancy of prostate cancer through regulation of miR-181a-5p/IRS2 pathway: Ki-67 protein molecular structure and function., PMID:40057086
IRS gene polymorphisms in Turkish patients with late-onset Alzheimer's disease., PMID:39954137
Insulin Receptor Substrate-2 Regulates the Secretion of Growth Factors in Response to Amino Acid Deprivation., PMID:39859555
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant., PMID:39835783
Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson's Disease., PMID:39830652
[Berberine regulates glucose and lipid metabolism via clock-controlled genes to ameliorate insulin resistance of hepatocytes]., PMID:39805783
The Glucose-Lowering Effect of Mesembryanthemum crystallinum and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats., PMID:39796627
Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats., PMID:39779784
Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer's Disease., PMID:39762668
Viscosol Treatment Ameliorates Insulin-Mediated Regulation of Dyslipidemia, Hepatic Steatosis, and Lipid Metabolism by Targeting PTP1B in Type-2 Diabetic Mice Model., PMID:39759127
Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak., PMID:39736467
Assessment of Changes in the Expression of Genes Involved in Insulin Signaling and Glucose Transport in Leukocytes of Women with Gestational Diabetes During Pregnancy and in the Postpartum Period., PMID:39684804
Identification of lipid metabolism-related biomarkers and prognostic analysis in geriatric patients with sepsis., PMID:39616476
Association between insulin-associated gene polymorphisms and new-onset diabetes mellitus in statin-treated patients., PMID:39614667
Metformin effectively alleviates the symptoms of Alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal., PMID:39585487
Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice., PMID:39574625
Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis., PMID:39566466
Prenatal choline supplementation enhances metabolic outcomes with differential impact on DNA methylation in Wistar rat offspring and dams., PMID:39547266
Highland Barley Alleviates High-Fat Diet-Induced Obesity and Liver Injury Through the IRS2/PI3K/AKT Signaling Pathway in Rats., PMID:39458511
ASPSCR1::TFE3-mediated upregulation of insulin receptor substrate 2 (IRS-2) activates PI3K/AKT signaling and promotes malignant phenotype., PMID:39419345
Anti-OAcGD2 antibody in combination with ceramide kinase inhibitor mediates potent antitumor cytotoxicity against breast cancer and diffuse intrinsic pontine glioma cells., PMID:39395135
Crosstalk between MIR-96 and IRS/PI3K/AKT/VEGF cascade in hRPE cells; A potential target for preventing diabetic retinopathy., PMID:39348384
Distinct Genomic Expression Signatures after Low-Force Electrically Induced Exercises in Persons with Spinal Cord Injury., PMID:39337673
Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function., PMID:39305958
Comparative Effects of Tumor Necrosis Factor Alpha, Lipopolysaccharide, and Palmitate on Mitochondrial Dysfunction in Cultured 3T3-L1 Adipocytes., PMID:39269560
IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis., PMID:39253856
HMGA1 Regulates IRS2 to Promote Inflammatory Responses and Oxidative Stress Injury in MPP+-Induced cells., PMID:39244689
RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2., PMID:39232805
Physiological and pathophysiological actions of insulin in the liver., PMID:39231651
Evaluating combined effects of chronic, low-dose exposures of cadmium (CLEC) and hyperglycemia on insulin signaling dysfunction in a hepatocellular model., PMID:39191366
Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster., PMID:39134590
Improving insulin resistance by sulforaphane via activating the Bacteroides and Lactobacillus SCFAs-GPR-GLP1 signal axis., PMID:39045769
[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation]., PMID:39034804
Bta-miR-200a Regulates Milk Fat Biosynthesis by Targeting IRS2 to Inhibit the PI3K/Akt Signal Pathway in Bovine Mammary Epithelial Cells., PMID:38996051
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm., PMID:38887896
For research use only. Not for human or drug use.
