Catalog No.
YHD63001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu236-Thr271
Predicted molecular weight
32.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24530
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endothelin receptor type B, EDNRB, ETRB, ET-BR, Endothelin receptor non-selective type, ET-B
Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas. PMID: 15604257
Endothelin receptor B is required for the expansion of melanocyte precursors and malignant melanoma. PMID: 15906230
Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B. PMID: 27864359
Endothelin-1 promotes human germinal vesicle-stage oocyte maturation by downregulating connexin-26 expression in cumulus cells. PMID: 29126233
EDNRB/EDN3 and Hirschsprung disease type II. PMID: 11434563
Prognostic values of EDNRB in triple-negative breast cancer. PMID: 32934717
Review and update of mutations causing Waardenburg syndrome. PMID: 20127975
Ednrb -/- mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestine. PMID: 35959491
Waardenburg Syndrome. PMID: 32809714
Waardenburg syndrome. PMID: 9279758
EDNRB Reverses Methylprednisolone-Mediated Decrease in Neural Progenitor Cell Viability via Regulating PI3K/Akt Pathway and lncRNA Expression. PMID: 31760579
News from the endothelin-3/EDNRB signaling pathway: Role during enteric nervous system development and involvement in neural crest-associated disorders. PMID: 30171849
Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage. PMID: 31150867
Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma. PMID: 32394530
A gene regulatory network explains RET-EDNRB epistasis in Hirschsprung disease. PMID: 31313802
Unraveling molecular mechanisms of head and neck cancer. PMID: 35932993
EDNRB isoform 3 confers Temozolomide resistance in A375 melanoma cells by modulating membrane potential, reactive oxygen species and mitochondrial Ca2. PMID: 31496797
The heterozygous EDNRB mutation in a Chinese family with Waardenburg syndrome type I. PMID: 31544051
EDNRB gene variants and melanoma risk in two southern European populations. PMID: 21507037
High-altitude adaptation in humans: from genomics to integrative physiology. PMID: 28951950
KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. PMID: 20162572
Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease. PMID: 32687927
Novel variants in EDNRB gene in Waardenburg syndrome type II and SOX10 gene in PCWH syndrome. PMID: 33234331
Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. PMID: 24326135
EDNRB and DCC salivary rinse hypermethylation has a similar performance as expert clinical examination in discrimination of oral cancer/dysplasia versus benign lesions. PMID: 23637120
EDNRB mutations cause Waardenburg syndrome type II in the heterozygous state. PMID: 28236341
[Hereditary hypomelanocytoses: the role of PAX3, SOX10, MITF, SNAI2, KIT, EDN3 and EDNRB genes]. PMID: 24379252
Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. PMID: 23579558
EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling. PMID: 27134165
E. coli JM83 damages the mucosal barrier in Ednrb knockout mice to promote the development of Hirschsprung‑associated enterocolitis via activation of TLR4/p‑p38/NF‑κB signaling. PMID: 35302172
Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background. PMID: 22975636
Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma. PMID: 33575475
Andrographolide Promotes Interaction Between Endothelin-Dependent EDNRA/EDNRB and Myocardin-SRF to Regulate Pathological Vascular Remodeling. PMID: 35127859
Transcriptomic analysis and ednrb expression in cochlear intermediate cells reveal developmental differences between inner ear and skin melanocytes. PMID: 33484097
The effect of miR-124-3p on cell proliferation and apoptosis in bladder cancer by targeting EDNRB. PMID: 31572460
Homozygous EDNRB mutation in a patient with Waardenburg syndrome type 1. PMID: 28502583
CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. PMID: 22213152
Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco. PMID: 35301649
Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells. PMID: 31734650
Identification of nine novel variants across PAX3, SOX10, EDNRB, and MITF genes in Waardenburg syndrome with next-generation sequencing. PMID: 36331148
Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. PMID: 16328051
Low expression of endothelin receptor B (EDNRB) is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid cystic carcinoma. PMID: 26166030
Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer. PMID: 21264540
Epigenetic and genetic alterations of the EDNRB gene in nasopharyngeal carcinoma. PMID: 18187958
Promoter hypermethylation of the EDNRB gene in nasopharyngeal carcinoma. PMID: 11920632
Identification of aberrant promoter methylation of EDNRB gene in esophageal squamous cell carcinoma. PMID: 18564167
c-Ret-mediated hearing losses. PMID: 22295143
Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung's disease. PMID: 14669347
Adamdec1, Ednrb and Ptgs1/Cox1, inflammation genes upregulated in the intestinal mucosa of obese rats, are downregulated by three probiotic strains. PMID: 28512356
New test for endothelin receptor type B (EDNRB) mutation genotyping in horses. PMID: 27039359
Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis. PMID: 32170852
Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics. PMID: 30332284
Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb. PMID: 12574515
Molecular characterization of four induced alleles at the Ednrb locus. PMID: 9371807
Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. PMID: 15294878
Cloning and association analysis of KIT and EDNRB polymorphisms with dominant white coat color in the Chinese raccoon dog (Nyctereutes procyonoides procyonoides). PMID: 26125860
Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. PMID: 8852660
High-incidence spontaneous tumors in JF1/Ms mice: relevance of hypomorphic germline mutation and subsequent promoter methylation of Ednrb. PMID: 24194353
Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain. PMID: 21782343
LncRNA TGFB2-AS1 regulates lung adenocarcinoma progression via act as a sponge for miR-340-5p to target EDNRB expression. PMID: 32774737
Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. PMID: 16391877
A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo. PMID: 28356074
RET and EDNRB mutation screening in patients with Hirschsprung disease: Functional studies and its implications for genetic counseling. PMID: 26395553
Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells. PMID: 28779103
Coexpression of recombinant adenovirus carrying GDNF and EDNRB genes in neural stem cells in vitro. PMID: 23504906
QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations. PMID: 22132166
Endothelin receptor B (EDNRB) is not the causative gene of the English spotting locus in the domestic rabbit (Oryctolagus cuniculus). PMID: 20497153
New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease. PMID: 20009762
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. PMID: 16650841
Significant Association of rs2147555 Genetic Polymorphism in the EDNRB Gene with Hirschsprung Disease in Southern Chinese Children. PMID: 33178831
Aberrant methylated EDNRB can act as a potential diagnostic biomarker in sporadic colorectal cancer while KISS1 is controversial. PMID: 28140749
Exclusion of EDNRB and KIT as the basis for white spotting in Border Collies. PMID: 11178229
The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment. PMID: 34288510
Genetic variation in the GDNF promoter affects its expression and modifies the severity of Hirschsprung's disease (HSCR) in rats carrying Ednrb(sl) mutations. PMID: 26318480
Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. PMID: 22897442
New variations of the EDNRB gene and its association with sporadic Hirschsprung's disease in Korea. PMID: 17011274
Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension. PMID: 18758497
Association of endothelin-beta receptor (EDNRB) gene variants in anorectal malformations. PMID: 17618893
Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis. PMID: 36396948
Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura. PMID: 19558538
Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage. PMID: 16412618
Novel Neuropathic Pain Mechanisms Associated With Allergic Inflammation. PMID: 31920952
Altered neuronal density and neurotransmitter expression in the ganglionated region of Ednrb null mice: implications for Hirschsprung's disease. PMID: 23360229
The Genetics of Deafness in Domestic Animals. PMID: 26664958
Sacral neural crest-derived cells enter the aganglionic colon of Ednrb-/- mice along extrinsic nerve fibers. PMID: 21858821
Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor. PMID: 18497345
For research use only. Not for human or drug use.
