Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas. PMID: 15604257
Endothelin receptor B is required for the expansion of melanocyte precursors and malignant melanoma. PMID: 15906230
Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B. PMID: 27864359
Endothelin-1 promotes human germinal vesicle-stage oocyte maturation by downregulating connexin-26 expression in cumulus cells. PMID: 29126233
EDNRB/EDN3 and Hirschsprung disease type II. PMID: 11434563
Prognostic values of EDNRB in triple-negative breast cancer. PMID: 32934717
Review and update of mutations causing Waardenburg syndrome. PMID: 20127975
Ednrb -/- mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestine. PMID: 35959491
Waardenburg Syndrome. PMID: 32809714
Waardenburg syndrome. PMID: 9279758
EDNRB Reverses Methylprednisolone-Mediated Decrease in Neural Progenitor Cell Viability via Regulating PI3K/Akt Pathway and lncRNA Expression. PMID: 31760579
News from the endothelin-3/EDNRB signaling pathway: Role during enteric nervous system development and involvement in neural crest-associated disorders. PMID: 30171849
Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage. PMID: 31150867
Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma. PMID: 32394530
A gene regulatory network explains RET-EDNRB epistasis in Hirschsprung disease. PMID: 31313802
Unraveling molecular mechanisms of head and neck cancer. PMID: 35932993
EDNRB isoform 3 confers Temozolomide resistance in A375 melanoma cells by modulating membrane potential, reactive oxygen species and mitochondrial Ca2. PMID: 31496797
The heterozygous EDNRB mutation in a Chinese family with Waardenburg syndrome type I. PMID: 31544051
EDNRB gene variants and melanoma risk in two southern European populations. PMID: 21507037
High-altitude adaptation in humans: from genomics to integrative physiology. PMID: 28951950
KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. PMID: 20162572
Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease. PMID: 32687927
Novel variants in EDNRB gene in Waardenburg syndrome type II and SOX10 gene in PCWH syndrome. PMID: 33234331
Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. PMID: 24326135
EDNRB and DCC salivary rinse hypermethylation has a similar performance as expert clinical examination in discrimination of oral cancer/dysplasia versus benign lesions. PMID: 23637120
EDNRB mutations cause Waardenburg syndrome type II in the heterozygous state. PMID: 28236341
[Hereditary hypomelanocytoses: the role of PAX3, SOX10, MITF, SNAI2, KIT, EDN3 and EDNRB genes]. PMID: 24379252
Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. PMID: 23579558
EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling. PMID: 27134165
E. coli JM83 damages the mucosal barrier in Ednrb knockout mice to promote the development of Hirschsprung‑associated enterocolitis via activation of TLR4/p‑p38/NF‑κB signaling. PMID: 35302172
Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background. PMID: 22975636
Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma. PMID: 33575475
Andrographolide Promotes Interaction Between Endothelin-Dependent EDNRA/EDNRB and Myocardin-SRF to Regulate Pathological Vascular Remodeling. PMID: 35127859
Transcriptomic analysis and ednrb expression in cochlear intermediate cells reveal developmental differences between inner ear and skin melanocytes. PMID: 33484097
The effect of miR-124-3p on cell proliferation and apoptosis in bladder cancer by targeting EDNRB. PMID: 31572460
Homozygous EDNRB mutation in a patient with Waardenburg syndrome type 1. PMID: 28502583
CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. PMID: 22213152
Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco. PMID: 35301649
Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells. PMID: 31734650
Identification of nine novel variants across PAX3, SOX10, EDNRB, and MITF genes in Waardenburg syndrome with next-generation sequencing. PMID: 36331148
Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. PMID: 16328051
Low expression of endothelin receptor B (EDNRB) is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid cystic carcinoma. PMID: 26166030
Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer. PMID: 21264540
Epigenetic and genetic alterations of the EDNRB gene in nasopharyngeal carcinoma. PMID: 18187958
Promoter hypermethylation of the EDNRB gene in nasopharyngeal carcinoma. PMID: 11920632
Identification of aberrant promoter methylation of EDNRB gene in esophageal squamous cell carcinoma. PMID: 18564167
c-Ret-mediated hearing losses. PMID: 22295143
Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung's disease. PMID: 14669347
Adamdec1, Ednrb and Ptgs1/Cox1, inflammation genes upregulated in the intestinal mucosa of obese rats, are downregulated by three probiotic strains. PMID: 28512356
New test for endothelin receptor type B (EDNRB) mutation genotyping in horses. PMID: 27039359
Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis. PMID: 32170852
Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics. PMID: 30332284
Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb. PMID: 12574515
Molecular characterization of four induced alleles at the Ednrb locus. PMID: 9371807
Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. PMID: 15294878
Cloning and association analysis of KIT and EDNRB polymorphisms with dominant white coat color in the Chinese raccoon dog (Nyctereutes procyonoides procyonoides). PMID: 26125860
Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. PMID: 8852660
High-incidence spontaneous tumors in JF1/Ms mice: relevance of hypomorphic germline mutation and subsequent promoter methylation of Ednrb. PMID: 24194353
Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain. PMID: 21782343
LncRNA TGFB2-AS1 regulates lung adenocarcinoma progression via act as a sponge for miR-340-5p to target EDNRB expression. PMID: 32774737
Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. PMID: 16391877
A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo. PMID: 28356074
RET and EDNRB mutation screening in patients with Hirschsprung disease: Functional studies and its implications for genetic counseling. PMID: 26395553
Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells. PMID: 28779103
Coexpression of recombinant adenovirus carrying GDNF and EDNRB genes in neural stem cells in vitro. PMID: 23504906
QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations. PMID: 22132166
Endothelin receptor B (EDNRB) is not the causative gene of the English spotting locus in the domestic rabbit (Oryctolagus cuniculus). PMID: 20497153
New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease. PMID: 20009762
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. PMID: 16650841
Significant Association of rs2147555 Genetic Polymorphism in the EDNRB Gene with Hirschsprung Disease in Southern Chinese Children. PMID: 33178831
Aberrant methylated EDNRB can act as a potential diagnostic biomarker in sporadic colorectal cancer while KISS1 is controversial. PMID: 28140749
Exclusion of EDNRB and KIT as the basis for white spotting in Border Collies. PMID: 11178229
The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment. PMID: 34288510
Genetic variation in the GDNF promoter affects its expression and modifies the severity of Hirschsprung's disease (HSCR) in rats carrying Ednrb(sl) mutations. PMID: 26318480
Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. PMID: 22897442
New variations of the EDNRB gene and its association with sporadic Hirschsprung's disease in Korea. PMID: 17011274
Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension. PMID: 18758497
Association of endothelin-beta receptor (EDNRB) gene variants in anorectal malformations. PMID: 17618893
Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis. PMID: 36396948
Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura. PMID: 19558538
Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage. PMID: 16412618
Novel Neuropathic Pain Mechanisms Associated With Allergic Inflammation. PMID: 31920952
Altered neuronal density and neurotransmitter expression in the ganglionated region of Ednrb null mice: implications for Hirschsprung's disease. PMID: 23360229
The Genetics of Deafness in Domestic Animals. PMID: 26664958
Sacral neural crest-derived cells enter the aganglionic colon of Ednrb-/- mice along extrinsic nerve fibers. PMID: 21858821
Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor. PMID: 18497345
Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis., PMID:40416975
Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism., PMID:40263271
Understanding metabolic characteristics and molecular mechanisms of large to giant congenital melanocytic nevi: implications for melanoma risk and therapeutic targets., PMID:40190193
Epigenetic alteration of smooth muscle cells regulates endothelin-dependent blood pressure and hypertensive arterial remodeling., PMID:40146226
Novel genetic determinants contribute to hearing loss in a central European cohort with enlarged vestibular aqueduct., PMID:40121402
Enteric neural crest development in Astyanax mexicanus surface fish and cavefish., PMID:40060476
Identification of potential biomarkers for lung cancer using integrated bioinformatics and machine learning approaches., PMID:40014586
The Impact of Mutant EDNRB on the Two-End Black Coat Color Phenotype in Chinese Local Pigs., PMID:40002960
Aberrant DNA methylation of EDNRB, MGMT and TIMP3 gene promoters in saliva of head and neck carcinoma patients as a diagnostic tool., PMID:39847241
Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer., PMID:39827145
EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway., PMID:39788311
Short-term estradiol administration does not restore endothelin-B receptor-mediated vasodilation in postmenopausal women., PMID:39773019
Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells., PMID:39756968
Microglial cell proliferation is regulated, in part, by reactive astrocyte ETBR signaling after ischemic stroke., PMID:39716588
[Molecular mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology]., PMID:39701680
Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development., PMID:39641974
The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development., PMID:39555938
Angiopoietin-1 attenuates lipopolysaccharide-induced endotoxemia in a Hirschsprung's disease murine model by improving intestinal vascular integrity: implications for treating postoperative Hirschsprung-associated enterocolitis., PMID:39466437
Enhancement of enteric neural stem cell neurogenesis by glial cell-derived neurotrophic factor in experimental Hirschsprung's disease., PMID:39460767
Right Ventricular Hypertrophy in Spontaneously Hypertensive Rats (SHR/NHsd) Is Associated with Inter-Individual Variations of the Pulmonary Endothelin System., PMID:39452062
Structure of endothelin ETB receptor-Gi complex in a conformation stabilized by unique NPxxL motif., PMID:39414992
Identification of immune-related hub genes in spinal cord injury., PMID:39367463
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis., PMID:39347789
Mechanism of Mongolian mind-body interactive therapy in regulating essential hypertension through HTR2B: A metabolome- and transcriptome-based study., PMID:39319128
Genomic analyses of intricate interaction of TE-lncRNA overlapping genes with miRNAs in human diseases., PMID:39215947
Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue., PMID:39174539
Adipocyte endothelin B receptor activation inhibits adiponectin production and causes insulin resistance in obese mice., PMID:39096077
Molecular mechanism of the endothelin receptor type B interactions with Gs, Gi, and Gq., PMID:39043181
Enteric neural stem cell transplant restores gut motility in mice with Hirschsprung disease., PMID:39042470
Comprehensive analysis of the endothelin system in the kidneys of mice, rats, and humans., PMID:38904098
Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein., PMID:38860875
Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries., PMID:38643219
Methylation analysis of DCC gene in saliva samples is an efficient method for non-invasive detection of superficial hypopharyngeal cancer., PMID:38538728
Mesenchymal Stem Cells Attenuates Hirschsprung diseases - Associated Enterocolitis by Reducing M1 Macrophages Infiltration via COX-2 Dependent Mechanism., PMID:38508971
Identification of new subtypes and potential genetic signatures in triple-negative breast cancer using weighted gene co-expression network analysis., PMID:38305604
Enhanced quality of hESC-derived melanocytes through modified concentration of endothelin-1., PMID:38284190
Refining breast cancer biomarker discovery and drug targeting through an advanced data-driven approach., PMID:38253993
High incidence of EDNRB gene mutation in seven southern Chinese familial cases with Hirschsprung's disease., PMID:38253735
Putative role of endothelin receptor B in the development and maintenance of taste buds within the circumvallate papillae., PMID:38220089
EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway., PMID:38205153
Genome-wide DNA methylation of lesional and peri-lesional skin in vitiligo: a comparative and integrated analysis of multi-omics in Chinese population., PMID:38182908
Genome-wide detection of selection signatures in Jianli pigs reveals novel cis-regulatory haplotype in EDNRB associated with two-end black coat color., PMID:38166718
Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis., PMID:38166688
Endothelin receptor B-deficient mice are protected from high-fat diet-induced metabolic syndrome., PMID:38159882
Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo., PMID:38159176
The mechanisms underlying alcohol-induced decreased splenic size: A network meta-analysis study., PMID:38059389
RET enhancer haplotype-dependent remodeling of the human fetal gut development program., PMID:37948459
ET-1 receptor type B (ETBR) overexpression associated with ICAM-1 downregulation leads to inflammatory attenuation in experimental autoimmune myocarditis., PMID:37901475
Suppression of PGE2/EP2 signaling alleviates Hirschsprung disease by upregulating p38 mitogen-activated protein kinase activity., PMID:37522903
Apoptosis Related Human Wharton's Jelly-Derived Stem Cells Differentiation into Osteoblasts, Chondrocytes, Adipocytes and Neural-like Cells-Complete Transcriptomic Assays., PMID:37373173
For research use only. Not for human or drug use.
