Catalog No.
YHD66001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly166-Glu193
Predicted molecular weight
31.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25103
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
TAC1R, Tachykinin receptor 1, NK-1R, NK1R, SPR, TACR1, Substance-P receptor, NK-1 receptor
Parallel ascending spinal pathways for affective touch and pain. PMID: 33116307
HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G1/S cycle. PMID: 33866937
Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance. PMID: 34730627
A spinoparabrachial circuit defined by Tacr1 expression drives pain. PMID: 33591273
The pharmacology of itch. PMID: 31612462
Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds. PMID: 35053363
MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells. PMID: 29896303
TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. PMID: 23078527
Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats. PMID: 23419547
The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice. PMID: 29459872
G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer? PMID: 26251921
NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. PMID: 19204064
Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice. PMID: 35972457
LncRNA RMRP silence curbs neonatal neuroblastoma progression by regulating microRNA-206/tachykinin-1 receptor axis via inactivating extracellular signal-regulated kinases. PMID: 30582709
TACR1 gene polymorphism and sex differences in postoperative nausea and vomiting. PMID: 26012530
Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome. PMID: 24817687
Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice. PMID: 22471406
Neurokinin receptors in drug and alcohol addiction. PMID: 32067964
Targeting tachykinin receptors in neuroblastoma. PMID: 27888795
Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene. PMID: 28493529
Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. PMID: 18452185
G-Protein Coupled Receptor Dysregulation May Play Roles in Severe Preeclampsia-A Weighted Gene Correlation Network Analysis of Placental Gene Expression Profile. PMID: 35269385
lncRNA RMRP knockdown suppress hepatocellular carcinoma biological activities via regulation miRNA-206/TACR1. PMID: 31579977
Frequent promoter hypermethylation of tachykinin-1 and tachykinin receptor type 1 is a potential biomarker for head and neck cancer. PMID: 23420374
NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls. PMID: 21577011
Bioinformatics analysis of key biomarkers for retinoblastoma. PMID: 34187205
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity. PMID: 34236855
Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma. PMID: 28870781
Expression of Truncated Neurokinin-1 Receptor in Childhood Neuroblastoma is Independent of Tumor Biology and Stage. PMID: 29061788
Bidirectional relationship between alcohol intake and sensitivity to social defeat: association with Tacr1 and Avp expression. PMID: 28150369
Alleles on rat chromosome 4 (D4Got41-Fabp1/Tacr1) regulate subphenotypes of obesity. PMID: 15833945
The rs3771863 single nucleotide polymorphism of the TACR1 gene is associated to a lower risk of sicca syndrome in fibromyalgia patients. PMID: 25786041
Transcription factor specificity protein 1 modulates TGFβ1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P. PMID: 29558695
Expression of tachykinin receptors (tacr1a and tacr1b) in zebrafish: influence of cocaine and opioid receptors. PMID: 23256992
The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch. PMID: 33051347
Induction of the neurokinin 1 receptor by TNFα in endometriotic tissue provides the potential for neurogenic control over endometriotic lesion growth. PMID: 23553861
Fine mapping of the 2p11 dyslexia locus and exclusion of TACR1 as a candidate gene. PMID: 15007729
Pathophysiologic mechanisms of itch in bullous pemphigoid. PMID: 31351883
The expression of tachykinin receptors in the human lower esophageal sphincter. PMID: 26852958
Neurogenic inflammation and migraine: implications for the therapeutics. PMID: 16249526
Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kappaB via a G(q)-dependent pathway. PMID: 17041011
Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice. PMID: 27621226
Mild Traumatic Brain Injury in Mice Beneficially Alters Lung NK1R and Structural Protein Expression to Enhance Survival after Pseudomonas aeruginosa Infection. PMID: 30472211
Differential mRNA expression of TACR1 after ischemic peritoneal trauma: a pilot animal study. PMID: 21837425
Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes. PMID: 33640716
P2RX7 in Dopaminergic Neurons of Ventral Periaqueductal Gray Mediates HTWP Acupuncture-Induced Consciousness in Traumatic Brain Injury. PMID: 33519382
The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death. PMID: 32210435
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. PMID: 19092807
Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR. PMID: 35013118
Potential in vitro therapeutic effects of targeting SP/NK1R system in cervical cancer. PMID: 34766230
Virokinin, a bioactive peptide of the tachykinin family, is released from the fusion protein of bovine respiratory syncytial virus. PMID: 12952986
Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. PMID: 23499760
The neuropeptide substance P regulates aldosterone secretion in human adrenals. PMID: 32471973
Neuroepithelial control of mucosal inflammation in acute cystitis. PMID: 30030504
Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma. PMID: 29969634
Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats. PMID: 34986062
SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. PMID: 26188273
Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons. PMID: 28291261
Behavioural and neurochemical abnormalities in mice lacking functional tachykinin-1 (NK1) receptors: a model of attention deficit hyperactivity disorder. PMID: 19748515
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. PMID: 30604743
The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions. PMID: 30724698
Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation. PMID: 17448763
SP/NK1R system regulates carcinogenesis in prostate cancer: Shedding light on the antitumoral function of aprepitant. PMID: 35134443
Evaluation of a Neurokinin-1 Receptor-Targeted Technetium-99m Conjugate for Neuroendocrine Cancer Imaging. PMID: 31292915
Effects of Early Life Stress on Bone Homeostasis in Mice and Humans. PMID: 32927845
Imaging of intermittent lipid-receptor interactions reflects changes in live cell membranes upon agonist-receptor binding. PMID: 31792325
LOC134466 methylation promotes oncogenesis of endometrial carcinoma through LOC134466/hsa-miR-196a-5p/TAC1 axis. PMID: 30485833
Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. PMID: 35642741
Potency, efficacy, and selectivity of GR64349 at human recombinant neurokinin NK2 and NK1 receptors. PMID: 31445972
Current research in pathophysiology of opioid-induced respiratory depression, neonatal opioid withdrawal syndrome, and neonatal antidepressant exposure syndrome. PMID: 35734228
The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma. PMID: 35434136
Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency. PMID: 23516556
Endokinin A/B stimulates rat gastric motility through myogenic NK1 receptors located in the fundus. PMID: 32365302
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression. PMID: 33577922
Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata. PMID: 27456549
miR-206 Promotes Cancer Progression by Targeting Full-Length Neurokinin-1 Receptor in Breast Cancer. PMID: 31506061
Exonic mutations in SCN9A (NaV1.7) are found in a minority of patients with erythromelalgia. PMID: 29911575
Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY. PMID: 29807224
Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Comparative Study From Sudan. PMID: 30241275
Prognostic Significance of Substance P/Neurokinin 1 Receptor and Its Association with Hormonal Receptors in Breast Carcinoma. PMID: 34692834
A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641. PMID: 35600049
Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis. PMID: 29055075
Agomelatine pretreatment prevents development of hyperglycemia and hypoinsulinemia in streptozotocin-induced diabetes in mice. PMID: 30216538
Upregulated expression of substance P and NK1R in blood monocytes and B cells of patients with allergic rhinitis and asthma. PMID: 36001730
Neuronal modulation of lung injury induced by polymeric hexamethylene diisocyanate in mice. PMID: 17673270
The molecular mechanism of the transcriptional activator SWI regulating gene ARID1B affecting swallowing dysfunction after stroke in rats. PMID: 34620277
The substance P and neurokinin-1 receptor system in human thyroid cancer: an immunohistochemical study. PMID: 32363847
Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling. PMID: 27712014
The NK1 receptor antagonist L822429 reduces heroin reinforcement. PMID: 23303056
For research use only. Not for human or drug use.
