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Recombinant Human GPR37 Protein, N-GST & C-His

Catalog #:   YHA50001 Specific References (98) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O15354
Protein length: Arg401-Leu443
Overview

Catalog No.

YHA50001

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Arg401-Leu443

Predicted molecular weight

32.97 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O15354

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Endothelin B receptor-like protein 1, G-protein coupled receptor 37, Prosaposin receptor GPR37, Parkin-associated endothelin receptor-like receptor, GPR37, PAELR, ETBR-LP-1

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human GPR37 protein
References

Inflammation and Infection in Pain and the Role of GPR37. PMID: 36430912

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. PMID: 30010619

GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma. PMID: 35934193

Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. PMID: 33731716

Orphan G Protein Coupled Receptors in Affective Disorders. PMID: 32599826

Ecto-GPR37: a potential biomarker for Parkinson's disease. PMID: 33637132

Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1. PMID: 26635605

Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain. PMID: 34678058

GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability. PMID: 24371137

G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation. PMID: 34601807

Orphan G protein-coupled receptors: The role in CNS disorders. PMID: 29268243

Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. PMID: 35457105

Cytosolic GPR37, but not GPR37L1, multimerization and its reversal by Parkin: A live cell imaging study. PMID: 34822195

GPR37 and Related Receptors: Disease Regulation. PMID: 37047695

Folding Underlies Bidirectional Role of GPR37/Pael-R in Parkinson Disease. PMID: 28629580

GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. PMID: 19799451

Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice. PMID: 31268736

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses. PMID: 28007645

Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1. PMID: 31903766

Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics. PMID: 29643766

GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice. PMID: 31143101

Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. PMID: 28642167

GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin. PMID: 34042202

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. PMID: 23690594

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. PMID: 25824528

GPR37 Receptors and Megalencephalic Leukoencephalopathy with Subcortical Cysts. PMID: 35628339

GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling. PMID: 34884663

Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37. PMID: 30260505

Emerging Roles for the Orphan GPCRs, GPR37 and GPR37 L1, in Stroke Pathophysiology. PMID: 35409385

Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6. PMID: 28341812

GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke. PMID: 33839144

Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line. PMID: 23121049

Osteocalcin Alleviates Lipopolysaccharide-Induced Acute Inflammation via Activation of GPR37 in Macrophages. PMID: 35625743

Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. PMID: 9799598

The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells. PMID: 24290813

Mice lacking the Parkinson's related GPR37/PAEL receptor show non-motor behavioral phenotypes: age and gender effect. PMID: 23574697

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37. PMID: 32292338

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. PMID: 28842709

[Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells]. PMID: 29973325

A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival. PMID: 25169131

The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. PMID: 16443751

Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. PMID: 9339362

The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding. PMID: 26869225

CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation. PMID: 25977097

Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. PMID: 25609427

Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor. PMID: 19218498

G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum. PMID: 31290447

G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. PMID: 26961174

Comparative analysis of protein-protein interaction networks in metastatic breast cancer. PMID: 35045088

GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells. PMID: 30423289

Mutation in Parkinson disease-associated, G-protein-coupled receptor 37 (GPR37/PaelR) is related to autism spectrum disorder. PMID: 23251443

Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. PMID: 33208571

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain. PMID: 23398388

GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs. PMID: 17519329

Multipathway In Vitro Pharmacological Characterization of Specialized Proresolving G Protein-Coupled Receptors. PMID: 35125345

REG4 promotes peritoneal metastasis of gastric cancer through GPR37. PMID: 27036049

The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review. PMID: 30904492

Systematic protein-protein interaction mapping for clinically relevant human GPCRs. PMID: 28298427

Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury. PMID: 35788904

Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37. PMID: 30010628

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice. PMID: 30578680

Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, DeltaFosB expression, and conditioned place preference to amphetamine and cocaine. PMID: 21372109

Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor. PMID: 15218106

Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. PMID: 25862943

The protective role of prosaposin and its receptors in the nervous system. PMID: 25130661

The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. PMID: 24749734

G protein-linked signaling pathways in bipolar and major depressive disorders. PMID: 24391664

G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. PMID: 28795439

Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37). PMID: 36194973

Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. PMID: 36750499

Impaired Aversive Memory Formation in GPR37L1KO Mice. PMID: 36430766

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. PMID: 16724068

Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats. PMID: 31215019

Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration. PMID: 19398891

Identification of prognosis-related hub genes of ovarian cancer through bioinformatics analyses and experimental verification. PMID: 36086731

Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. PMID: 36696997

Pael receptor, endoplasmic reticulum stress, and Parkinson's disease. PMID: 14579121

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. PMID: 29656342

[Physiological Roles of Ubiquitin Ligases Related to the Endoplasmic Reticulum]. PMID: 27252059

Neurodegeneration: how does parkin prevent Parkinson's disease? PMID: 12842030

Use of viral vectors to create animal models for Parkinson's disease. PMID: 22227451

The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice. PMID: 35008836

G protein-coupled receptor genes in the FANTOM2 database. PMID: 12819145

[Possible involvement of HRD1 (ubiquitin E3 ligase) in neurodegenerative diseases]. PMID: 19443960

New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery. PMID: 32259091

[Molecular pharmacological studies on the protection mechanism against endoplasmic reticulum stress-induced neurodegenerative disease]. PMID: 23208051

Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease. PMID: 17465880

The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion. PMID: 34379697

A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease. PMID: 29496607

Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. PMID: 37075680

Cloning and developmental expression of a chick G-protein-coupled receptor SCGPR1. PMID: 17251065

Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. PMID: 19763624

Expression of prosaposin and its receptors in the rat cerebellum after kainic acid injection. PMID: 30135931

Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death. PMID: 31378367

Proteomic profiling reveals antitumor effects of RT2 peptide on a human colon carcinoma xenograft mouse model. PMID: 35032485

Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. PMID: 24428929

Vitamin D Metabolites Inhibit Hepatitis C Virus and Modulate Cellular Gene Expression. PMID: 26594646

What's all the RAVE about receptor internalization? PMID: 10482227

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant Human GPR37 Protein, N-GST & C-His [YHA50001]
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