Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression. PMID: 35253629
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis. PMID: 35023014
Cellular Id1 inhibits hepatitis B virus transcription by interacting with the novel covalently closed circular DNA-binding protein E2F4. PMID: 34975318
E2f4 is required for intestinal and otolith development in zebrafish. PMID: 35403704
Regulation of ischemic neuronal death by E2F4-p130 protein complexes. PMID: 24828495
Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression. PMID: 30047092
E2F4 transcription factor is a prognostic biomarker related to immune infiltration of head and neck squamous cell carcinoma. PMID: 35840663
Host cell factor-1 and E2F4 interact via multiple determinants in each protein. PMID: 16633736
Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4. PMID: 24100580
E2F4 plays a key role in Burkitt lymphoma tumorigenesis. PMID: 22475873
E2f4 and E2f5 are essential for the development of the male reproductive system. PMID: 26825228
E2F4 cooperates with pRB in the development of extra-embryonic tissues. PMID: 19433082
E2F4 expression patterns in SIV encephalitis. PMID: 15925101
In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver. PMID: 24573694
A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice. PMID: 35254651
E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning? PMID: 30537487
E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. PMID: 31270324
Transcriptional regulation of multiciliated cell differentiation. PMID: 32362381
E2F4 deficiency promotes drug-induced apoptosis. PMID: 15611646
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. PMID: 11030352
E2F4 is required for cardiomyocyte proliferation. PMID: 19955219
pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. PMID: 20023434
Cell cycle-related transformation of the E2F4-p130 repressor complex. PMID: 16153605
Stable overexpression of p130/E2F4 affects the multipotential abilities of bone-marrow-derived mesenchymal stem cells. PMID: 29987913
E2F4 modulates differentiation and gene expression in hematopoietic progenitor cells during commitment to the lymphoid lineage. PMID: 18322175
E2F4 is exported from the nucleus in a CRM1-dependent manner. PMID: 11158323
E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation. PMID: 16861343
E2F4 regulates the cell cycle and DNA replication in the silkworm, Bombyx mori. PMID: 34913261
E2F4 is required for early eye patterning. PMID: 19325228
Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. PMID: 17531812
Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice. PMID: 30841904
E2F4 functions as a tumour suppressor in acute myeloid leukaemia via inhibition of the MAPK signalling pathway by binding to EZH2. PMID: 31943751
Herpes simplex virus induces intracellular redistribution of E2F4 and accumulation of E2F pocket protein complexes. PMID: 10366563
E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA. PMID: 17507799
Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. PMID: 21247883
High Expression of E2F4 Is an Adverse Prognostic Factor and Related to Immune Infiltration in Oral Squamous Cell Carcinoma. PMID: 36567912
Curcumin Attenuates Hydrocephalus via Activation of E2F Transcription Factor 4. PMID: 35421860
E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma. PMID: 17043659
E2F4-induced AGAP2-AS1 up-regulation accelerates the progression of colorectal cancer via miR-182-5p/CFL1 axis. PMID: 34838479
Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. PMID: 28675157
E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. PMID: 34260288
The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients. PMID: 28464832
An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. PMID: 17121828
Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4. PMID: 32239565
E2F4 may be a core transcription factor in the lncRNA-TF regulatory network in cervical cancer. PMID: 35262965
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. PMID: 23093672
circ_0041732 Promotes Breast Cancer Progression. PMID: 35838496
The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells. PMID: 36883841
E2f4 is required for normal development of the airway epithelium. PMID: 17383628
Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon. PMID: 17537963
Cell cycle control by a methylation-phosphorylation switch. PMID: 21311233
S-phase-coupled apoptosis in tumor suppression. PMID: 21437646
E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. PMID: 19562678
Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. PMID: 30218642
Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4. PMID: 19306992
Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes. PMID: 22985930
The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. PMID: 12604789
E2F4 is essential for normal erythrocyte maturation and neonatal viability. PMID: 10983976
The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions. PMID: 9405335
The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. PMID: 26369285
The human papillomavirus E7 protein shines a spotlight on the pRB family member, p130. PMID: 16582614
[The relationship between frameshift mutations of transforming growth factor-beta type II receptor, insulin growth factor II receptor, bcl-2 associated X protein, E2F4 and microsatellite instability in gastric carcinoma]. PMID: 16635398
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. PMID: 8622916
A mechanism of COOH-terminal binding protein-mediated repression. PMID: 16254191
Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression. PMID: 18504435
Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells. PMID: 15231644
Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations. PMID: 20581455
Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue. PMID: 16505226
LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74. PMID: 32314545
Molecular cloning, expression, and characterization of E2F transcription factor 4 from Antheraea pernyi. PMID: 28436337
MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes. PMID: 28987387
p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes. PMID: 24096481
Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters. PMID: 29059406
Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. PMID: 17957245
Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449
E2F4 loss suppresses tumorigenesis in Rb mutant mice. PMID: 12498715
Mutations of the E2F4 gene in hematological malignancies having microsatellite instability. PMID: 10666234
Role of specific CCAAT/enhancer-binding protein isoforms in intestinal epithelial cells. PMID: 11559710
Cyclin D1/cdk4 can interact with E2F4/DP1 and disrupts its DNA-binding capacity. PMID: 17894419
Necdin-E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery. PMID: 22138333
ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells. PMID: 23919615
Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family. PMID: 27567532
Multicilin and activated E2f4 induce multiciliated cell differentiation in primary fibroblasts. PMID: 30120325
Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. PMID: 18997819
E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation. PMID: 10454552
TGFbeta-mediated formation of pRb-E2F complexes in human myeloid leukemia cells. PMID: 18294958
Induction of Wnt/β-catenin signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3β/β-catenin complex. PMID: 21631154
The nucleocytoplasmic shuttling of E2F4 is involved in the regulation of human intestinal epithelial cell proliferation and differentiation. PMID: 15040009
E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. PMID: 9144170
G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression. PMID: 12401786
Regulation of the G1/S transition phase in mesangial cells by E2F1. PMID: 10504464
Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis. PMID: 15811856
E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. PMID: 10779331
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. PMID: 17001309
FAM20C Modulates Neuronal Differentiation in Hypoxic-Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A-Dependent H3K9me3 Regulation., PMID:40511628
Large Yellow Croaker (Pseudosciaena crocea, Richardson) E2F4, a Cyclin-Dependent Transcription Factor, Forms a Heterodimer with DP1., PMID:40508152
mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins., PMID:40307619
p53 regulates DREAM complex-mediated repression in a p21-independent manner., PMID:40038454
The evolution and functional characterization of transcription factors E2Fs in lamprey, Lethenteron reissneri., PMID:40031963
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer., PMID:39930267
Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation., PMID:39662468
Study of the Role of E2F1 and TMEM132A in Prostate Cancer Development., PMID:39473405
The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells., PMID:39341888
Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1., PMID:39309429
NUCB2 promotes hepatocellular carcinoma cell growth and metastasis by activating the E2F4/PTGR1 axis., PMID:39309426
Transcription factor E2F4 facilitates SUMOylation to promote HCC progression through interaction with LIN9., PMID:39239750
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis., PMID:39043964
CD133 expression is associated with less DNA repair, better response to chemotherapy and survival in ER-positive/HER2-negative breast cancer., PMID:39017815
DREAM On, DREAM Off: A Review of the Estrogen Paradox in Luminal A Breast Cancers., PMID:38927507
Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors., PMID:38795876
The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence., PMID:38783095
The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms., PMID:38678032
POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase., PMID:38575587
USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy., PMID:38491202
Related cellular signaling and consequent pathophysiological outcomes of ubiquitin specific protease 24., PMID:38395384
Selective Occupation by E2F and RB of Loci Expressed by RNA Polymerase III., PMID:38339234
RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis., PMID:38253523
Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways., PMID:37929634
Potential Signature Therapeutic Biomarkers TOP2A, MAD2L1, and CDK1 in Colorectal Cancer: A Systems Biomedicine-Based Approach., PMID:37884851
Glycolysis Promotes Angiotensin II-Induced Aortic Remodeling Through Regulating Endothelial-to-Mesenchymal Transition via the Corepressor C-Terminal Binding Protein 1., PMID:37795602
CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor., PMID:37759078
ZNF500 abolishes breast cancer proliferation and sensitizes chemotherapy by stabilizing P53 via competing with MDM2., PMID:37700392
A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities., PMID:37661832
Uncovering Novel Roles of miR-122 in the Pathophysiology of the Liver: Potential Interaction with NRF1 and E2F4 Signaling., PMID:37627157
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression., PMID:37612308
Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells., PMID:37567906
Subcellular localization of nucleolar protein 14 and its proliferative function mediated by miR-17-5p and E2F4 in pancreatic cancer., PMID:37506248
Interfering with Dusp2 alleviates high glucose-induced vascular endothelial cell dysfunction by promoting p38 MAPK pathway activation., PMID:37479052
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics., PMID:37349788
Activation of Wnt/β‑Catenin‑p130/E2F4 promotes the differentiation of bone marrow‑derived mesenchymal stem cells into type II alveolar epithelial cells through cell cycle arrest., PMID:37346406
Integrin-Driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program., PMID:37277179
Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening., PMID:37270558
Elucidating the pharmacological effects of Compound Kushen injection on MYC-P15-CCND1 signaling pathway in nasopharyngeal carcinoma - An in vitro study., PMID:37257705
DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features., PMID:36933392
GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program., PMID:36932059
Role of E2F transcription factor in oral cancer: Recent insight and advancements., PMID:36924812
The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells., PMID:36883841
Decursin inhibits EGFR-ERK1/2 signaling axis in advanced human prostate carcinoma cells., PMID:36597263
Gene expression profile analysis to discover molecular signatures for early diagnosis and therapies of triple-negative breast cancer., PMID:36567949
High Expression of E2F4 Is an Adverse Prognostic Factor and Related to Immune Infiltration in Oral Squamous Cell Carcinoma., PMID:36567912
E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging., PMID:36292945
Potential Biomarkers and Signaling Pathways Associated with the Pathogenesis of Primary Ameloblastoma: A Systems Biology Approach., PMID:36160115
Loss of Rbl2 (Retinoblastoma-Like 2) Exacerbates Myocardial Ischemia/Reperfusion Injury., PMID:36129061
GIV is a promising novel poor prognostic factor in liver hepatocellular carcinoma., PMID:35960100
For research use only. Not for human or drug use.
