Expression of GnRH receptor in the canine corpus luteum, and luteal function following deslorelin acetate-induced puberty delay. PMID: 28963736
Canine placental prostaglandin E2 synthase: expression, localization, and biological functions in providing substrates for prepartum PGF2alpha synthesis. PMID: 25297547
Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. PMID: 33558271
Validation of the SHOX2/PTGER4 DNA Methylation Marker Panel for Plasma-Based Discrimination between Patients with Malignant and Nonmalignant Lung Disease. PMID: 27544059
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. PMID: 32322056
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche. PMID: 34496236
Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy. PMID: 34740924
Construction of TME and Identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma. PMID: 34028567
PTGER4 modulating variants in Crohn's disease. PMID: 24793213
Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones. PMID: 32191640
PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts. PMID: 26538147
Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer. PMID: 32256818
Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis. PMID: 32846747
DNA methylation of PTGER4 in peripheral blood plasma helps to distinguish between lung cancer, benign pulmonary nodules and chronic obstructive pulmonary disease patients. PMID: 33662689
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. PMID: 35256606
The performance of the SHOX2/PTGER4 methylation assay is influenced by cancer stage, age, type and differentiation. PMID: 32250153
Significance of Hypermethylation of Tumor-Suppressor Genes PTGER4 and ZNF43 at CpG Sites in the Prognosis of Colorectal Cancer. PMID: 36142151
PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. PMID: 23300802
Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY. PMID: 34468315
Diagnosis of pulmonary nodules by DNA methylation analysis in bronchoalveolar lavage fluids. PMID: 34620221
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. PMID: 34385262
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis. PMID: 34239062
Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis. PMID: 28400866
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression. PMID: 34262017
Prostaglandin E receptor 4 (PTGER4) involved in host protection against immune challenge in oyster, Crassostrea hongkongensis. PMID: 25463295
[DNA methylation detection of SHOX2 and PTGER4 in plasma contributes to differential diagnosis of pulmonary nodule patients]. PMID: 31167696
Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. PMID: 19075289
JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients: a case-control study. PMID: 24069348
A panel of DNA methylation biomarkers for detection and improving diagnostic efficiency of lung cancer. PMID: 34408226
Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level. PMID: 30191681
Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice. PMID: 29415894
Characterization of genome-wide copy number aberrations in colonic mixed adenoneuroendocrine carcinoma and neuroendocrine carcinoma reveals recurrent amplification of PTGER4 and MYC genes. PMID: 28899736
[GENETIC INTERACTIONS BETWEEN ADRB2 AND PTGER4 ON RESPONSES TO SALMETEROL OR MONTELUKAST IN JAPANESE PATIENTS WITH MILD PERSISTENT ASTHMA]. PMID: 27885204
Pharmacogenetic biomarkers of response in Crohn's disease. PMID: 28631723
Targeting therapeutics to bone by conjugation with bisphosphonates. PMID: 29626715
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PMID: 17447842
The genetics of Crohn's disease. PMID: 19453248
Ankylosis in ankylosing spondylitis: current concepts. PMID: 25935456
Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases. PMID: 30917700
Molecular genetic mechanisms of chronic urticaria. PMID: 24404388
The genetics of inflammatory bowel disease. PMID: 17919503
Lipids as targets for novel anti-inflammatory therapies. PMID: 19576246
New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease. PMID: 36091713
Genetic variability of prostaglandin E2 receptor subtype EP4 gene in aspirin-intolerant chronic urticaria. PMID: 22695889
EP2 and EP4 prostanoid receptor signaling. PMID: 14607241
Prostaglandin E(2) receptors in bone formation. PMID: 17593365
Prostaglandin E2/EP4 axis is upregulated in Spondyloarthritis and contributes to radiographic progression. PMID: 37075950
GPCRomics of Homeostatic and Disease-Associated Human Microglia. PMID: 34054860
The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad? PMID: 20829404
Investigations on the potential role of prostaglandin E2 in canine uterine inertia. PMID: 34544012
Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation. PMID: 35379745
Analgesic strategies beyond the inhibition of cyclooxygenases. PMID: 16876882
Prostaglandin EP4 receptor mRNA expression in canine lymphoma. PMID: 34250711
From gene variants to novel therapies. Is the prostaglandin e2 pathway in primary graft dysfunction ready for prime time? PMID: 24579833
Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer. PMID: 27869171
The role of genetics in inflammatory bowel disease. PMID: 18473763
Glutathione-S-transferase A3 protein suppresses thiram-induced tibial dyschondroplasia by regulating prostaglandin-related genes expression. PMID: 33129574
Targeting prostaglandin E EP receptors to inhibit metastasis. PMID: 17047037
Prostaglandins differentially modulate mucosal-associated invariant T-cell activation and function according to stimulus. PMID: 36541521
Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth. PMID: 21589857
Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission. PMID: 15098064
A Novel Diagnosis Method Based on Methylation Analysis of SHOX2 and Serum Biomarker for Early Stage Lung Cancer. PMID: 33167712
Identification of biomarkers related to copper metabolism in patients with pulmonary arterial hypertension. PMID: 36690956
Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases. PMID: 36155972
[Role of EP4 receptor in bone resorption induced by PGE]. PMID: 11338379
The differential role of prostaglandin E2 receptors EP3 and EP4 in regulation of fever. PMID: 16534751
Prostanoids in immunity: roles revealed by mice deficient in their receptors. PMID: 14607267
Prostaglandin receptors of the EP2 and EP4 subtypes regulate B lymphocyte activation and differentiation to IgE-secreting cells. PMID: 9561124
Identification of prostaglandin receptors in human ureters. PMID: 23227994
[A study for functions of prostaglandin E receptor EP4 subtype by analysing knockout mice]. PMID: 11201161
Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence. PMID: 19426119
Gene expression of prostaglandin EP4 receptor in three canine carcinomas. PMID: 32571310
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. PMID: 35260562
VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. PMID: 30948641
Ber-EP4 staining in effusion cytology: A potential source of false positives. PMID: 33726887
Prostaglandin EP4 antagonists. PMID: 24237064
EP4 receptor as a novel promising therapeutic target in colon cancer. PMID: 33190014
EP4 as a Therapeutic Target for Aggressive Human Breast Cancer. PMID: 29596308
The prostanoid EP4 receptor and its signaling pathway. PMID: 23776144
EP4 agonist. PMID: 18249273
E-type prostanoid receptor 4 (EP4) in disease and therapy. PMID: 23523686
Grapiprant: an EP4 prostaglandin receptor antagonist and novel therapy for pain and inflammation. PMID: 29067176
The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling. PMID: 26830476
EP4 as a Negative Prognostic Factor in Patients with Vulvar Cancer. PMID: 33808776
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells. PMID: 35914351
Prostaglandin E2 receptor EP4 regulates cell migration through Orai1. PMID: 31755615
Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation. PMID: 32321307
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. PMID: 30643142
Potential therapeutic interventions via EP2/EP4 prostaglandin receptors. PMID: 22706114
Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. PMID: 21697732
EP4 activation ameliorates liver ischemia/reperfusion injury via ERK1/2‑GSK3β‑dependent MPTP inhibition. PMID: 32186754
Eicosanoids in Cancer: Prostaglandin E2 Receptor 4 in Cancer Therapeutics and Immunotherapy. PMID: 32547404
Activation of EP4 alleviates AKI-to-CKD transition through inducing CPT2-mediated lipophagy in renal macrophages. PMID: 36467025
A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis. PMID: 35208999
Cyclooxygenase-2 contributes to diabetic nephropathy through glomerular EP4 receptor. PMID: 35131551
TNF-α impairs EP4 signaling through the association of TRAF2-GRK2 in primary fibroblast-like synoviocytes. PMID: 33859345
EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes. PMID: 32722929
The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway. PMID: 36078128
Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia. PMID: 35549670
Epithelial EP4 plays an essential role in maintaining homeostasis in colon. PMID: 31645712
For research use only. Not for human or drug use.
