FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling. PMID: 35904816
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3. PMID: 35230915
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling. PMID: 33907746
FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. PMID: 26378236
Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants. PMID: 35468861
Neurodevelopmental phenotype associated with CHD8-SUPT16H duplication. PMID: 31823155
FACT caught in the act of manipulating the nucleosome. PMID: 31775157
De novo variants in SUPT16H cause neurodevelopmental disorders associated with corpus callosum abnormalities. PMID: 31924697
Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. PMID: 33230303
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG. PMID: 33852836
Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20. PMID: 24357716
Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression. PMID: 31439637
The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. PMID: 22031019
Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay. PMID: 26834018
Recurrent ∼100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly. PMID: 25257502
Validation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: focus on ZNF521. PMID: 25774781
Structural basis for H2A-H2B recognitions by human Spt16. PMID: 36801613
Naked FACT is unstable. PMID: 23856583
Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription. PMID: 33526453
The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus. PMID: 11471063
Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes. PMID: 36577379
Long term follow-up in a patient with a de novo microdeletion of 14q11.2 involving CHD8. PMID: 25735987
The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin. PMID: 30508113
Nek9, a novel FACT-associated protein, modulates interphase progression. PMID: 14660563
A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8. PMID: 30670789
Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells. PMID: 23839038
Structure of the human histone chaperone FACT Spt16 N-terminal domain. PMID: 26841762
A new small supernumerary marker chromosome involving 14pter → q12 in a child with severe neurodevelopmental retardation: case report and literature review. PMID: 24013083
FACT facilitates transcription-dependent nucleosome alteration. PMID: 12934006
The structural basis of human Spt16 N-terminal domain interaction with histone (H3-H4)2 tetramer. PMID: 30528735
The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain. PMID: 9832518
Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. PMID: 11432837
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9. PMID: 34021025
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. PMID: 26842758
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. PMID: 10817755
The FACT Complex Promotes Avian Leukosis Virus DNA Integration. PMID: 28122976
FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER. PMID: 30715484
The CENP-T/-W complex is a binding partner of the histone chaperone FACT. PMID: 27284163
Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. PMID: 30029006
Changing the DNA landscape: putting a SPN on chromatin. PMID: 12596908
Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p. PMID: 32860308
Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. PMID: 23973375
Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. PMID: 16682447
Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. PMID: 23325844
Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells. PMID: 36769360
Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding. PMID: 26687053
Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. PMID: 21969370
The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. PMID: 10421373
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. PMID: 18406329
Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers. PMID: 23831030
Human SSRP1 has Spt16-dependent and -independent roles in gene transcription. PMID: 17209051
Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts. PMID: 34113352
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. PMID: 11239457
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. PMID: 22713873
Copy number variation analysis in adults with catatonia confirms haploinsufficiency of SHANK3 as a predisposing factor. PMID: 27519580
Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis. PMID: 25446273
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. PMID: 12242279
The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. PMID: 11927560
Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells. PMID: 21998152
Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68. PMID: 10792464
Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. PMID: 12524332
Novel deletions of 14q11.2 associated with developmental delay, cognitive impairment and similar minor anomalies in three children. PMID: 17545556
Repairing nucleosomes during transcription. PMID: 14583736
Proteomic Analysis of Invasive Breast Cancer Cells Treated with CBD Reveals Proteins Associated with the Reversal of Their Epithelial-Mesenchymal Transition Induced by IL-1β., PMID:40429863
Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27., PMID:40391177
Nuclear circGUSBP1 promotes cancer stemness via transcriptional coordination with OCT4., PMID:40360086
MST1 interactomes profiling across cell death in esophageal squamous cell carcinoma., PMID:39664081
A new case of SUPT16H-associated syndromic neurodevelopmental delay., PMID:38818817
The FAcilitates Chromatin Transcription complex regulates the ratio of glycolysis to oxidative phosphorylation in neural stem cells., PMID:38719542
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2., PMID:38478295
Targeting FAcilitates Chromatin Transcription complex inhibits pleural mesothelioma and enhances immunotherapy., PMID:37974213
Single-cell RNA sequencing identifies macrophage signatures correlated with clinical features and tumour microenvironment in meningiomas., PMID:37515398
Structural basis for H2A-H2B recognitions by human Spt16., PMID:36801613
Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells., PMID:36769360
Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes., PMID:36577379
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling., PMID:35904816
Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants., PMID:35468861
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3., PMID:35230915
Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts., PMID:34113352
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9., PMID:34021025
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling., PMID:33907746
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG., PMID:33852836
Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription., PMID:33526453
Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h., PMID:33230303
Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p., PMID:32860308
De novo variants in SUPT16H cause neurodevelopmental disorders associated with corpus callosum abnormalities., PMID:31924697
Neurodevelopmental phenotype associated with CHD8-SUPT16H duplication., PMID:31823155
FACT caught in the act of manipulating the nucleosome., PMID:31775157
Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression., PMID:31439637
FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER., PMID:30715484
A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8., PMID:30670789
The structural basis of human Spt16 N-terminal domain interaction with histone (H3-H4)2 tetramer., PMID:30528735
The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin., PMID:30508113
Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level., PMID:30029006
The FACT Complex Promotes Avian Leukosis Virus DNA Integration., PMID:28122976
Copy number variation analysis in adults with catatonia confirms haploinsufficiency of SHANK3 as a predisposing factor., PMID:27519580
The CENP-T/-W complex is a binding partner of the histone chaperone FACT., PMID:27284163
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability., PMID:26842758
Structure of the human histone chaperone FACT Spt16 N-terminal domain., PMID:26841762
Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay., PMID:26834018
Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding., PMID:26687053
FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency., PMID:26378236
Validation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: focus on ZNF521., PMID:25774781
Long term follow-up in a patient with a de novo microdeletion of 14q11.2 involving CHD8., PMID:25735987
Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis., PMID:25446273
Recurrent ∼100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly., PMID:25257502
Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20., PMID:24357716
A new small supernumerary marker chromosome involving 14pter → q12 in a child with severe neurodevelopmental retardation: case report and literature review., PMID:24013083
Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage., PMID:23973375
"Naked" FACT is unstable., PMID:23856583
Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells., PMID:23839038
Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers., PMID:23831030
Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription., PMID:23325844
For research use only. Not for human or drug use.
