Catalog No.
YHK90701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg30-Lys115
Predicted molecular weight
37.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H598
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GABA and glycine transporter, Vesicular inhibitory amino acid transporter, VGAT, Solute carrier family 32 member 1, Vesicular GABA transporter, hVIAAT, SLC32A1, VIAAT
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. PMID: 33367648
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission. PMID: 36073542
Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction. PMID: 36588318
Association of SLC32A1 Missense Variants With Genetic Epilepsy With Febrile Seizures Plus. PMID: 34038384
Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons. PMID: 37035505
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. PMID: 12566983
Membrane glycine transport proteins. PMID: 12750892
The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids. PMID: 36741325
Identifying colon cancer stage related genes and their cellular pathways. PMID: 23506890
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. PMID: 26094607
Wakefulness Is Governed by GABA and Histamine Cotransmission. PMID: 21723258
Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array). PMID: 35551574
Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse. PMID: 12354619
Why glycine transporters have different stoichiometries. PMID: 29569008
Dopamine receptors in the rat entopeduncular nucleus. PMID: 35204719
Neural Differentiation of Human Dental Mesenchymal Stem Cells Induced by ATRA and UDP-4: A Comparative Study. PMID: 31025941
Disordered breathing in a mouse model of Dravet syndrome. PMID: 25723967
Corelease of acetylcholine and GABA from cholinergic forebrain neurons. PMID: 34040635
Transcriptome Analysis of Choroid and Retina From Tree Shrew With Choroidal Neovascularization Reveals Key Signaling Moieties. PMID: 36626425
Bioinformatics and systems biology approaches to identify the effects of COVID-19 on neurodegenerative diseases: A review. PMID: 26364548
Markedly Lower Glutamic Acid Decarboxylase 67 Protein Levels in a Subset of Boutons in Schizophrenia. PMID: 11099457
The vesicular neurotransmitter transporters: current perspectives and future prospects. PMID: 16106993
Heterogeneity of axon terminals expressing VGLUT1 in the cerebral neocortex. PMID: 36189793
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons. PMID: 33895810
Contribution of Excitatory and Inhibitory Neuronal Activity to BOLD fMRI. PMID: 16624492
Prenatal stress alters Fos protein expression in hippocampus and locus coeruleus stress-related brain structures. PMID: 22968646
Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain. PMID: 28356474
Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses. PMID: 28158493
Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6. PMID: 34174930
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia. PMID: 29950309
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. PMID: 31944441
VGLUT-VGAT expression delineates functionally specialised populations of vasopressin-containing neurones including a glutamatergic perforant path-projecting cell group to the hippocampus in rat and mouse brain. PMID: 27375434
Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. PMID: 20089906
Nitric oxide induces pathological synapse loss by a protein kinase G-, Rho kinase-dependent mechanism preceded by myosin light chain phosphorylation. PMID: 32615251
Increased GABAergic development in iPSC-derived neurons from patients with sporadic Alzheimer's disease. PMID: 32307700
Central afferents to the nucleus of the solitary tract in rats and mice. PMID: 30213622
Effects of agomelatine on electrocorticogram activity on penicillin-induced seizure model of rats. PMID: 33221837
Dendritic pathology, spine loss and synaptic reorganization in human cortex from epilepsy patients. PMID: 21666673
A readily retrievable pool of synaptic vesicles. PMID: 15951119
Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers. PMID: 14596849
Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain. PMID: 25242304
Single rodent mesohabenular axons release glutamate and GABA. PMID: 21093461
An intrinsic GABAergic system in human lymphocytes. PMID: 33130922
Nitric oxide controls excitatory/inhibitory balance in the hypoglossal nucleus during early postnatal development. PMID: 34311052
Nigrostriatal dopamine depletion promoted an increase in inhibitory markers (parvalbumin, GAD67, VGAT) and cold allodynia. PMID: 26010578
Immunogold characteristics of VGLUT3-positive GABAergic nerve terminals suggest corelease of glutamate. PMID: 30412707
Neurochemical fingerprinting of amygdalostriatal and intra-amygdaloid projections: a tracing-immunofluorescence study in the rat. PMID: 15555918
Morphologically identified glycinergic synapses in the hippocampus. PMID: 25174002
Reversal of theta rhythm flow through intact hippocampal circuits. PMID: 32183860
BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses. PMID: 18667749
Restoration of the luteinizing hormone surge in middle-aged female rats by altering the balance of GABA and glutamate transmission in the medial preoptic area. PMID: 29402935
Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. PMID: 22993444
Corelease of dopamine and GABA by a retinal dopaminergic neuron. PMID: 23637187
Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. PMID: 17662605
Tetrapeptide inhibitors of the glutamate vesicular transporter (VGLUT). PMID: 30368554
Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons. PMID: 16616431
Stable expression of the vesicular GABA transporter following photothrombotic infarct in rat brain. PMID: 21507951
Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures. PMID: 24141313
Network state-dependent inhibition of identified hippocampal CA3 axo-axonic cells in vivo. PMID: 22510271
Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons. PMID: 23804087
Sorting of the vesicular GABA transporter to functional vesicle pools by an atypical dileucine-like motif. PMID: 23851655
GABA is localized in dopaminergic synaptic vesicles in the rodent striatum. PMID: 19843525
Vesicular inhibitory amino acid transporter is a Cl-/gamma-aminobutyrate Co-transporter. PMID: 34576177
NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush. PMID: 28419997
Examining the Causal Role of Leptin in Alzheimer Disease: A Mendelian Randomization Study. PMID: 28823934
Structural alterations in fast-spiking GABAergic interneurons in a model of posttraumatic neocortical epileptogenesis. PMID: 33726812
α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice. PMID: 20943908
Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons. PMID: 23982982
Electron tomography on γ-aminobutyric acid-ergic synapses reveals a discontinuous postsynaptic network of filaments. PMID: 23386329
Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord. PMID: 26073293
Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD. PMID: 24361861
Altered cortical expression of GABA-related genes in schizophrenia: illness progression vs developmental disturbance. PMID: 28988851
Ablation of C-fibers decreases quantal size of GABAergic synaptic transmission in the insular cortex. PMID: 19252495
Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses. PMID: 23164505
Behavioural and neuroplastic properties of chronic lurasidone treatment in serotonin transporter knockout rats. PMID: 20067584
EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. PMID: 26349007
Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus. PMID: 29322238
Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex. PMID: 20442321
An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells. PMID: 24708928
Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons. PMID: 20718854
Perinatal development of inhibitory synapses in the nucleus tractus solitarii of the rat. PMID: 27335401
Distinct Fos-Expressing Neuronal Ensembles in the Ventromedial Prefrontal Cortex Mediate Food Reward and Extinction Memories. PMID: 18418735
PACAP-mediated neuroprotection of neurochemically identified cell types in MSG-induced retinal degeneration. PMID: 25749864
Co-expression of VGLUT1 and VGAT sustains glutamate and GABA co-release and is regulated by activity in cortical neurons. PMID: 23224682
Shift from phasic to tonic GABAergic transmission following laser-lesions in the rat visual cortex. PMID: 19738365
A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells. PMID: 29479060
A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling. PMID: 19103593
Time of day-dependent sorting of the vesicular glutamate transporter to the plasma membrane. PMID: 15746915
Inhibitory synapses in the developing auditory system are glutamatergic. PMID: 20519538
Synaptic and vesicular coexistence of VGLUT and VGAT in selected excitatory and inhibitory synapses. PMID: 21435381
Postsynaptic targets of GABAergic basal forebrain projections to the basolateral amygdala. PMID: 25286388
Presynaptic cell type-dependent regulation of GABAergic synaptic transmission by nitric oxide in rat insular cortex. PMID: 11166946
Evidence for microvesicular storage and release of glycine in rodent pinealocytes. PMID: 17711980
Developmental lineage of cell types in cortical dysplasia with balloon cells. PMID: 20685921
For research use only. Not for human or drug use.
