Catalog No.
YHD67501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Gly91
Predicted molecular weight
38.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25686
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HSJ-1, Heat shock protein J1, DNAJB2, Heat shock 40 kDa protein 3, DnaJ homolog subfamily B member 2, HSPF3, HSJ1
Charcot-Marie-Tooth Hereditary Neuropathy Overview. PMID: 20301532
The roles of HSP40/DNAJ protein family in neurodegenerative diseases. PMID: 36581576
DNAJB2-related Charcot-Marie-Tooth disease type 2: Pathomechanism insights and phenotypic spectrum widening. PMID: 35286755
Distal hereditary motor neuropathies: Mutation spectrum and genotype-phenotype correlation. PMID: 33369814
DNAJB2 expression in normal and diseased human and mouse skeletal muscle. PMID: 20395441
The heat shock protein DNAJB2 as a novel biomarker for essential thrombocythemia diagnosis associated with immune infiltration. PMID: 36746103
Chaperonopathies: Spotlight on Hereditary Motor Neuropathies. PMID: 28018906
DNAJB2 c.184C>T mutation associated with distal hereditary motor neuropathy with rimmed vacuolar myopathy. PMID: 35652544
Extension of the DNAJB2a isoform in a dominant neuromyopathy family. PMID: 37070754
Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. PMID: 28031292
Identification of a Large DNAJB2 Deletion in a Family with Spinal Muscular Atrophy and Parkinsonism. PMID: 27449489
Neuromuscular Diseases Due to Chaperone Mutations: A Review and Some New Results. PMID: 32093037
Charcot-Marie-Tooth Neuropathy Type 2 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY. PMID: 20301462
Genetic Analysis of HSP40/DNAJ Family Genes in Parkinson's Disease: a Large Case-Control Study. PMID: 35715682
Huntington's disease: fighting on many fronts. PMID: 22427330
[Genetic distribution in Chinese patients with hereditary peripheral neuropathy]. PMID: 36241230
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. PMID: 23607970
Mitochondrial dynamics and inherited peripheral nerve diseases. PMID: 25847151
Assessment of Targeted Next-Generation Sequencing as a Tool for the Diagnosis of Charcot-Marie-Tooth Disease and Hereditary Motor Neuropathy. PMID: 26752306
Suppression of protein aggregation by chaperone modification of high molecular weight complexes. PMID: 22396390
Gene expression profiling in human skeletal muscle during recovery from eccentric exercise. PMID: 18321953
Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. PMID: 11311562
Molecular analysis and clinical diversity of distal hereditary motor neuropathy. PMID: 32298515
A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation. PMID: 22522442
Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3. PMID: 21625540
PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates. PMID: 33837238
Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflammation in juvenile idiopathic arthritis. PMID: 17469159
Differences in Circulating microRNAs between Grazing and Grain-Fed Wagyu Cattle Are Associated with Altered Expression of Intramuscular microRNA, the Potential Target PTEN, and Lipogenic Genes. PMID: 27611783
HSJ1-related hereditary neuropathies: novel mutations and extended clinical spectrum. PMID: 25274842
Screening of hub genes and prediction of putative drugs in arsenic-related bladder carcinoma: An in silico study. PMID: 32663744
The expression of oxidative stress genes related to myocardial ischemia reperfusion injury in patients with ST-elevation myocardial infarction. PMID: 35237363
The Importance of Multiple Gene Analysis for Diagnosis and Differential Diagnosis in Charcot Marie Tooth Disease. PMID: 34169998
Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. PMID: 20889486
Interaction of the human DnaJ homologue, HSJ1b with the 90 kDa heat shock protein, Hsp90. PMID: 10983842
Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G. PMID: 27713507
Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. PMID: 24023695
HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome. PMID: 15936278
Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation. PMID: 15155768
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis. PMID: 26936937
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. PMID: 16604191
Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system? PMID: 15270696
Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (Bubalus Bubalis). PMID: 27682256
The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. PMID: 12754272
Assignment of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32-->q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids. PMID: 10516435
For research use only. Not for human or drug use.
