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Recombinant Human TRPS1 Protein, N-GST & C-His

Catalog #:   YHK90501 Specific References (146) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q9UHF7
Protein length: Lys400-Gly460
Overview

Catalog No.

YHK90501

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Lys400-Gly460

Predicted molecular weight

34.91 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9UHF7

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

TRPS1, Tricho-rhino-phalangeal syndrome type I protein, Zinc finger protein GC79, Zinc finger transcription factor Trps1

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human TRPS1 protein
References

TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. PMID: 33011748

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma. PMID: 35413381

TRPS1 Expression in Breast Carcinomas: Focusing on Metaplastic Breast Carcinomas. PMID: 35175968

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing. PMID: 35077667

Trichorhinophalangeal Syndrome. PMID: 28426188

Expression of TRPS1 in phyllodes tumor and sarcoma of the breast. PMID: 35063444

Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin. PMID: 36284362

Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo. PMID: 30712485

Trps1 Regulates Development of Craniofacial Skeleton and Is Required for the Initiation of Palatal Shelves Fusion. PMID: 31130868

Trps1 targets Ccnd1 to regulate mouse Leydig cell proliferation. PMID: 34185441

Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression. PMID: 20507941

Dual role of the Trps1 transcription factor in dentin mineralization. PMID: 25128529

Frequent TRPS1 expression in synovial sarcoma is associated with SS18-SSX fusion oncoprotein activity. PMID: 36162599

The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. PMID: 23892436

TRPS1 knockdown inhibits angiogenic vascular mimicry in human triple negative breast cancer cells. PMID: 34216368

TRPS1 expression promotes angiogenesis and affects VEGFA expression in breast cancer. PMID: 24595984

Significance of TRPS1 in the development and clinicopathologic of hepatocellular carcinoma. PMID: 33015773

The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles. PMID: 21630221

Increased expression of TRPS1 affects tumor progression and correlates with patients' prognosis of colon cancer. PMID: 23762846

High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia. PMID: 33926391

TRPS1 drives heterochromatic origin refiring and cancer genome evolution. PMID: 33691114

Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells. PMID: 30691926

TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells. PMID: 30082728

The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. PMID: 12885770

Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin Formation. PMID: 25999324

TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p. PMID: 33293831

Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. PMID: 11285235

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. PMID: 30380416

CHD4 mediates SOX2 transcription through TRPS1 in luminal breast cancer. PMID: 36075559

Functional mechanisms of TRPS1 in disease progression and its potential role in personalized medicine. PMID: 35863130

Reciprocal Regulation of TRPS1 and miR-221 in Intervertebral Disc Cells. PMID: 31569377

Transcription Factor Trps1 Promotes Tubular Cell Proliferation after Ischemia-Reperfusion Injury through cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D and AKT. PMID: 27466160

The TRPS1 transcription factor: androgenic regulation in prostate cancer and high expression in breast cancer. PMID: 15613454

Down-regulation of TRPS1 stimulates epithelial-mesenchymal transition and metastasis through repression of FOXA1. PMID: 26969828

Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. PMID: 22115758

Trps1 regulates biliary epithelial-mesenchymal transition and has roles during biliary fibrosis in liver grafts: a preliminary study. PMID: 25886207

Making extra teeth: Lessons from a TRPS1 mutation. PMID: 27706911

Trps1 functions downstream of Bmp7 in kidney development. PMID: 19820125

LncRNA PVT1 Regulates TRPS1 Expression in Breast Cancer by Sponging miR-543. PMID: 32982402

Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp. PMID: 18456591

Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth. PMID: 30071870

TRPS1 outperforms GATA3 in pleural effusions with metastatic breast carcinoma versus mesothelioma. PMID: 37096814

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development. PMID: 31879358

Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells. PMID: 33022456

Mutation analysis of TRPS1 gene including core promoter, 5'UTR, and 3'UTR regulatory sequences with insight into their organization. PMID: 27826100

Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma. PMID: 26377811

Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma. PMID: 35760555

A pilot study: Comparison of TRPS1 and GATA3 immunoperoxidase staining using cytologic smears in entities reportedly positive for GATA3. PMID: 35790088

A central role for TRPS1 in the control of cell cycle and cancer development. PMID: 25277197

Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene. PMID: 11773701

TRPS1 gene alterations in human subependymoma. PMID: 28528424

Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. PMID: 19759027

Trps1 is necessary for normal temporomandibular joint development. PMID: 22427063

Expression of miRNA-26b-5p and its target TRPS1 is associated with radiation exposure in post-Chernobyl breast cancer. PMID: 28944451

Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice. PMID: 27257806

NDRG1-PLAG1 and TRPS1-PLAG1 Fusion Genes in Chondroid Syringoma. PMID: 32345665

Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice. PMID: 22508542

Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression. PMID: 29601666

TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers. PMID: 29895970

The atypical GATA protein TRPS1 represses androgen-induced prostate-specific antigen expression in LNCaP prostate cancer cells. PMID: 14680804

Novel mutation of TRPS1 in a patient with tricho-rhino-phalangeal syndrome. PMID: 32844440

Trps1 is associated with the multidrug resistance of osteosarcoma by regulating MDR1 gene expression. PMID: 24491996

Novel Pathogenetic Variants in PTHLH and TRPS1 Genes Causing Syndromic Brachydactyly. PMID: 34897794

TRPS1 mutation associated with trichorhinophalangeal syndrome type 1 with 15 supernumerary teeth, hypoplastic mandibular condyles with slender condylar necks and unique hair morphology. PMID: 32347565

miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring. PMID: 31034522

TRPS1 expression in cytokeratin 5 expressing triple negative breast cancers, its value as a marker of breast origin. PMID: 37012444

Tricho-rhino-phalangeal syndrome with supernumerary teeth. PMID: 18946009

Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. PMID: 12446778

Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. PMID: 18363966

Paclitaxel Resistance Modulated by the Interaction between TRPS1 and AF178030.2 in Triple-Negative Breast Cancer. PMID: 35399640

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. PMID: 19389374

SUMOylation modulates transcriptional repression by TRPS1. PMID: 17391059

The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-β signaling. PMID: 23537899

A novel TRPS1 mutation in a family with tricho-rhino-phalangeal syndrome type 1. PMID: 24909213

Expression of Trps1 during mouse embryonic development. PMID: 12617849

Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. PMID: 17997399

Characterization of a Novel Frameshift Mutation Within the TRPS1 Gene Causing Trichorhinophalangeal Syndrome Type 1 in a Kindred Cypriot Family. PMID: 36093893

Clinical significance and biological function of transcriptional repressor GATA binding 1 in gastric cancer: a study based on data mining, RT-qPCR, immunochemistry, and vitro experiment. PMID: 33044891

GC79/TRPS1 and tumorigenesis in humans. PMID: 15690404

[Tricho-rhino-phalangeal syndrome due to a novel frameshift variation of the TRPS1 gene]. PMID: 31598943

Proteomic analysis of proteins regulated by TRPS1 transcription factor in DU145 prostate cancer cells. PMID: 17467349

Immunohistochemical expression of TRPS1 in mammary Paget disease, extramammary Paget disease, and their close histopathologic mimics. PMID: 36808637

Trichorhinophalangeal syndrome type II associated with aplasia cutis congenita in a neonate. PMID: 35181938

Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1. PMID: 12761050

Association of TRPS1 gene with different EMT markers in ERα-positive and ERα-negative breast cancer. PMID: 24934762

Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy. PMID: 31550480

A novel TRPS1 mutation in a Chinese patient with trichorhinophalangeal syndrome type I. PMID: 36376245

The Role of Tricho-Rhino-Phalangeal Syndrome (TRPS) 1 in Apoptosis during Embryonic Development and Tumor Progression. PMID: 24709795

An intragenic duplication of TRPS1 leading to abnormal transcripts and causing trichorhinophalangeal syndrome type I. PMID: 31662300

Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. PMID: 23133399

Immunohistochemical Markers for Distinguishing Metastatic Breast Carcinoma from Other Common Malignancies: Update and Revisit. PMID: 35461734

Long non-coding RNA KCNQ1OT1 promotes cell viability and migration as well as inhibiting degradation of CHON-001 cells by regulating miR-126-5p/TRPS1 axis. PMID: 34108052

Novel deletion mutation of TRPS1 gene in a Chinese patient of trichorhinophalangeal syndrome type I. PMID: 23510776

Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation. PMID: 23772552

Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression. PMID: 25514040

Cut out that YAPping: Mechanisms to reduce scar formation. PMID: 35120615

Genetic Determinants of Colonic Diverticulosis-A Systematic Review., PMID:40428403

[Clinicopathological features of primary thoracic synovial sarcoma: a study of 42 cases]., PMID:40302578

The diagnostic significance of immunohistochemical expression of SOX10 and TRPS1 in triple negative breast cancer., PMID:40245691

Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis., PMID:40197498

The Diagnostic Role of TFF1, TFF3, FOXA1, CA XII and TRPS1 in Serous Effusions., PMID:40170411

Trichorhinophalangeal syndrome type 1 (TRPS1) in breast pathology: diagnostic utility and pitfalls., PMID:40025593

Digenic impairments of haploinsufficient genes in patients with craniosynostosis., PMID:39989454

Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway., PMID:39979480

Genomic and Transcriptomic Profiling of Digital Papillary Adenocarcinomas Reveals Alterations in Matrix Remodeling and Metabolic Genes., PMID:39757862

TRPS1 is a useful marker in differentiating metastatic breast carcinoma from pancreatic adenocarcinoma in fine-needle aspiration specimens., PMID:39656998

Genome-wide association studies of ischemic stroke based on interpretable machine learning., PMID:39650478

TRPS1 Immunohistochemistry in Salivary Gland Neoplasms: Analysis on Cytology Cell Blocks and Surgical Follow-Up Correlation., PMID:39644132

Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex., PMID:39610085

Urinary DNA-methylation and protein biomarkers identify urothelial carcinoma among other genitourinary diseases and cancer-free individuals., PMID:39587670

TRPS1 expression in cytologic specimens of salivary duct carcinoma and other salivary gland tumors., PMID:39547127

Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes., PMID:39535579

A Comprehensive Review of TRPS1 as a Diagnostic Immunohistochemical Marker for Primary Breast Carcinoma: Latest Insights and Diagnostic Pitfalls., PMID:39518009

Evaluation of breast-specific marker expression in metastatic breast cancers: Correlation with subtype switch., PMID:39478414

Exploring the molecular landscape of cutaneous mixed tumors characterized by TRPS1::PLAG1 gene fusion., PMID:39468990

Expression of TRPS1 in Metastatic Tumors of the Skin: An Immunohistochemical Study of 72 Cases., PMID:39449380

Breast cancer with cervix, lung and neck metastases: a case report and literature review., PMID:39380862

[Tricho-rhino-phalangeal syndrome with TRPS1 gene variation in 3 children]., PMID:39327968

Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis., PMID:39307879

GATA factor TRPS1, a new DNA repair protein, cooperates with reversible PARylation to promote chemoresistance in patients with breast cancer., PMID:39276941

Trichorhinophalangeal syndrome 1 expression in breast and nonbreast metastases from Müllerian, lung, gastrointestinal tract, and pancreatic primary tumors by immunohistochemistry with cytology cell block specimens., PMID:39264831

TRPS1, a sensitive marker for different histological and molecular types of breast cancer., PMID:39243111

Deciphering Breast Origin in Malignant Effusions: The Diagnostic Utility of an MGP, GATA-3, and TRPS-1 Immunocytochemical Panel., PMID:39191231

Analysis of the function, mechanism and clinical application prospect of TRPS1, a new marker for breast cancer., PMID:39181273

Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation., PMID:39177752

TRPS1 expression in MPNST is correlated with PRC2 inactivation and loss of H3K27me3., PMID:39084565

UVB-induced TRPS1 regulates MITF transcription activity to promote skin pigmentation., PMID:39074626

The Combined Immunohistochemical Expression of GLI1 and BCOR in Synovial Sarcomas for the Identification of Three Risk Groups and Their Prognostic Outcomes: A Study of 52 Patients., PMID:39062853

TRPS1 Is Consistently Expressed in Hidradenoma Papilliferum., PMID:38959400

PLAG1-Rearranged Uterine Sarcomas: A Study of 11 Cases Showing a Wide Phenotypical Spectrum Not Limited to Myxoid Leiomyosarcoma-Like Morphology., PMID:38942115

TRPS1 expression in breast angiosarcoma., PMID:38902365

Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice., PMID:38899779

Frequent Immunohistochemical Expression of Transcriptional Repressor GATA Binding 1 in Salivary Gland Neoplasms: A Sensitive but Nonspecific Marker., PMID:38797518

TRPS1 function beyond breast: A retrospective immunohistochemical study on non-breast cytology specimens., PMID:38794964

Immunohistochemical Profile of Triple-Negative Breast Cancers: SOX10 and AR Dual Negative Tumors Have Worse Outcomes., PMID:38763422

Molecular analysis of apocrine mixed tumors and cutaneous myoepitheliomas: a comparative study confirming a continuous spectrum of one entity with near-ubiquitous PLAG1 and rare mutually exclusive HMGA2 gene rearrangements., PMID:38736009

Primary Cutaneous NUT Carcinoma: Clinicopathologic and Genetic Study of 4 Cases., PMID:38708710

TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity., PMID:38702730

Xenopus tropicalis osteoblast-specific open chromatin regions reveal promoters and enhancers involved in human skeletal phenotypes and shed light on early vertebrate evolution., PMID:38692409

How many phenotypes for the FBXO11 related disease? Report on a new patient with a tricho-rhino-phalangeal like phenotype., PMID:38679370

Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma., PMID:38656544

TRPS1 is a Highly Sensitive Marker for Breast Cancer: A Tissue Microarray Study Evaluating More Than 19,000 Tumors From 152 Different Tumor Entities., PMID:38647255

Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin., PMID:38613910

Clinical presentation and genetics of tricho-rhino-phalangeal syndrome (TRPS) type 1: A single-center case series of 15 patients and seven novel TRPS1 variants., PMID:38574886

Diagnostic utility and sensitivities of matrix Gla protein (MGP), TRPS1 and GATA3 in breast cancer: focusing on metastatic breast cancer, invasive breast carcinoma with special features, and salivary gland-type tumours., PMID:38570266

[Clinicopathological characteristics and immune microenvironment of breast squamous cell carcinoma]., PMID:38556816

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human TRPS1 Protein, N-GST & C-His [YHK90501]
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