Catalog No.
YHK90301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser425-Gln486
Predicted molecular weight
35.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UNF0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase C and casein kinase substrate in neurons protein 2, SdpII, Syndapin-2, Syndapin-II, PACSIN2
PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. PMID: 31801866
Possible regulation of caveolar endocytosis and flattening by phosphorylation of F-BAR domain protein PACSIN2/Syndapin II. PMID: 26745030
Super-resolution analysis of PACSIN2 and EHD2 at caveolae. PMID: 35834519
Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane. PMID: 26092940
Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. PMID: 35616009
PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli. PMID: 31390291
The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions. PMID: 27417273
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. PMID: 23129763
PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. PMID: 28550045
Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. PMID: 35352878
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. PMID: 21693584
FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. PMID: 25838348
Regulation of caveolae through cholesterol-depletion-dependent tubulation mediated by PACSIN2. PMID: 32878944
HIV-1 gag recruits PACSIN2 to promote virus spreading. PMID: 29891700
PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. PMID: 11076687
PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells. PMID: 36596605
PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients. PMID: 31792371
Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. PMID: 21610094
A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. PMID: 33972531
PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis. PMID: 18495106
Direct interaction of actin filaments with F-BAR protein pacsin2. PMID: 25216944
Proteomic Signature of Extracellular Vesicles for Lung Cancer Recognition. PMID: 34684727
PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. PMID: 22846425
PACSIN proteins in vivo: Roles in development and physiology. PMID: 34990060
HIV-1 packs in PACSIN2 for cell-to-cell spread. PMID: 29925599
RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread. PMID: 31242077
Energy and Dynamics of Caveolae Trafficking. PMID: 33692993
PACSIN2: a BAR-rier forming the megakaryocyte DMS. PMID: 26138537
Pathophysiological Role of Caveolae in Hypertension. PMID: 31355199
PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy. PMID: 27452984
Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. PMID: 27942025
Keeping in touch with the membrane; protein- and lipid-mediated confinement of caveolae to the cell surface. PMID: 32049332
Proteome Analysis of Temporomandibular Joint with Disc Displacement. PMID: 36267015
PACSIN2 does not influence thiopurine-related toxicity in patients with inflammatory bowel disease. PMID: 24896764
Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II. PMID: 20188097
The syndapin protein family: linking membrane trafficking with the cytoskeleton. PMID: 15226389
Caveolin1 Tyrosine-14 Phosphorylation: Role in Cellular Responsiveness to Mechanical Cues. PMID: 33089394
Physicochemical analysis from real-time imaging of liposome tubulation reveals the characteristics of individual F-BAR domain proteins. PMID: 23199228
Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF. PMID: 34342350
PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. PMID: 23918399
Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes. PMID: 34325130
The cytoplasmic protein Pacsin 2 in kidney development and injury repair. PMID: 23235565
OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates. PMID: 26510499
The Rac1 hypervariable region in targeting and signaling: a tail of many stories. PMID: 23354415
Deciphering the relationship between caveolae-mediated intracellular transport and signalling events. PMID: 35820545
Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants. PMID: 32221476
[BAR domain superfamily proteins bind to the cellular membrane of various curvatures]. PMID: 22416469
Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular Level. PMID: 35660026
Trim-Away mediated knock down uncovers a new function for Lbh during gastrulation of Xenopus laevis. PMID: 33159936
Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). PMID: 12023017
Role of the EHD2 unstructured loop in dimerization, protein binding and subcellular localization. PMID: 25875965
Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. PMID: 19549836
Application of a C. trachomatis expression system to identify C. pneumoniae proteins translocated into host cells. PMID: 33685970
The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane. PMID: 36433988
Myocardin Family Members Drive Formation of Caveolae. PMID: 26244347
Membrane tubule formation by banana-shaped proteins with or without transient network structure. PMID: 26863901
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. PMID: 30683896
Nucleophosmin1 is a negative regulator of the small GTPase Rac1. PMID: 23874639
Syndapins integrate N-WASP in receptor-mediated endocytosis. PMID: 12426380
A Network-Based Bioinformatics Approach to Identify Molecular Biomarkers for Type 2 Diabetes that Are Linked to the Progression of Neurological Diseases. PMID: 32041280
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. PMID: 22323287
PACSIN proteins bind tubulin and promote microtubule assembly. PMID: 18456257
Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis. PMID: 28748614
Molecular composition and ultrastructure of the caveolar coat complex. PMID: 24013648
SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy. PMID: 29683944
Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart. PMID: 29107716
Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. PMID: 21807942
Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. PMID: 23596323
Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells. PMID: 24500282
Role of phosphatidylinositol 4,5-bisphosphate in regulating EHD2 plasma membrane localization. PMID: 24040268
Interaction of SPIN90 with syndapin is implicated in clathrin-mediated endocytic pathway in fibroblasts. PMID: 16999739
Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity. PMID: 23888307
A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. PMID: 17761170
EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. PMID: 15930129
Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells. PMID: 22710396
Mutually exclusive interactions of EHD1 with GS32 and syndapin II. PMID: 15371016
A hinge in the distal end of the PACSIN 2 F-BAR domain may contribute to membrane-curvature sensing. PMID: 20471395
Syndapin isoforms participate in receptor-mediated endocytosis and actin organization. PMID: 10704453
PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins. PMID: 10431838
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. PMID: 16627472
Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. PMID: 24385601
All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. PMID: 11082044
Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae. PMID: 22718246
PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. PMID: 21200149
A Multi-Trait Association Analysis of Brain Disorders and Platelet Traits Identifies Novel Susceptibility Loci for Major Depression, Alzheimer's and Parkinson's Disease. PMID: 36672180
Dietary Supplementation of Vitamin E and α-Lipoic Acid Upregulates Cell Growth and Signaling Genes in Rat Myocardium. PMID: 23675004
For research use only. Not for human or drug use.
