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Recombinant Human SAA1 Protein, N-His-SUMO (YHC65502)

Applications:ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system:E. coli
Accession:P0DJI8
Protein length:Ser20-Tyr122
Overview

Catalog No.

YHC65502

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Ser20-Tyr122

Predicted molecular weight

23.87 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P0DJI8

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

SAA, Serum amyloid A-1 protein, SAA1, Amyloid fibril protein AA

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human SAA1 protein
References

Serum Amyloid A (SAA) Proteins. PMID: 32189310

Cancer-associated adipocytes promote pancreatic cancer progression through SAA1 expression. PMID: 32535957

Secondary, AA, Amyloidosis. PMID: 30274625

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. PMID: 31866067

Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway. PMID: 35247611

Serum amyloid A1 (SAA1) protein in human colostrum. PMID: 29511620

Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression. PMID: 33626219

Inhibition of Fatty Acid-Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition. PMID: 33101287

Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury. PMID: 30126923

SAA1 regulates pro-labour mediators in term labour by activating YAP pathway. PMID: 33719002

Serum level of serum amyloid A1 protein in patients with acne vulgaris. PMID: 34449969

Cell-to-cell transfer of SAA1 protein in a cell culture model of systemic AA amyloidosis. PMID: 28361953

Enhancement of cortisol-induced SAA1 transcription by SAA1 in the human amnion. PMID: 30817315

De novo Synthesis of SAA1 in the Placenta Participates in Parturition. PMID: 32582166

Serum amyloid A primes microglia for ATP-dependent interleukin-1β release. PMID: 29803222

SAA1 gene polymorphisms in osteoporosis patients. PMID: 30737305

SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress. PMID: 34597680

Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice. PMID: 32731813

Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome. PMID: 34980155

High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion. PMID: 34232570

SAA1 increases NOX4/ROS production to promote LPS-induced inflammation in vascular smooth muscle cells through activating p38MAPK/NF-κB pathway. PMID: 31216990

CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects. PMID: 27313400

Identification of SAA1 as a prognostic biomarker associated with immune infiltration in glioblastoma. PMID: 35574600

Serum Amyloid A1 (SAA1) Revisited: Restricted Leukocyte-Activating Properties of Homogeneous SAA1. PMID: 32477346

SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation. PMID: 33284950

Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis. PMID: 35126370

SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. PMID: 24608426

Expression of mouse apolipoprotein SAA1.1 in CE/J mice: isoform-specific effects on amyloidogenesis. PMID: 11140693

Differential protein expression in patients with urosepsis. PMID: 30340979

SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-κB/p38/JNK and TGFβ/Smad pathways. PMID: 37022639

Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages. PMID: 31100086

Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice. PMID: 35344382

Hepatocytes derived increased SAA1 promotes intrahepatic platelet aggregation and aggravates liver inflammation in NAFLD. PMID: 33813276

Investigating the pernicious effects of heparan sulfate in serum amyloid A1 protein aggregation: a structural bioinformatics approach. PMID: 33050843

A mutation in the SAA1 promoter causes hereditary amyloid A amyloidosis. PMID: 34560138

Involvement of STAT3 in the synergistic induction of 11β-HSD1 by SAA1 and cortisol in human amnion fibroblasts. PMID: 31131948

Silencing of SAA1 inhibits palmitate- or high-fat diet induced insulin resistance through suppression of the NF-κB pathway. PMID: 31060494

Mouse Bone Marrow Mesenchymal Stem Cells Inhibit Sepsis-Induced Lung Injury in Mice via Exosomal SAA1. PMID: 36173129

Diversity and complexity of the mouse Saa1 and Saa2 genes. PMID: 24521869

Serum amyloid A1: Structure, function and gene polymorphism. PMID: 26945629

Serum amyloid A and atherosclerosis. PMID: 27579547

Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection. PMID: 29042594

Cellular mechanism of fibril formation from serum amyloid A1 protein. PMID: 28637682

Quantification of SAA1 and SAA2 in lung cancer plasma using the isotype-specific PRM assays. PMID: 26177823

COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2. PMID: 29371208

Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A. PMID: 36309973

AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform. PMID: 24228751

Measurement of serum amyloid A1 (SAA1), a major isotype of acute phase SAA. PMID: 16375587

Both murine SAA1 and SAA2 yield AA amyloid in alveolar hydatid cyst-infected mice. PMID: 8633197

SAA1 alleles as risk factors in reactive systemic AA amyloidosis. PMID: 10036584

Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism. PMID: 19755416

SAA1 Has Potential as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, and an Indicator for Immune Infiltration of Tumor Microenvironment in Clear Cell Renal Cell Carcinoma. PMID: 37108666

The contribution of SAA1 polymorphisms to Familial Mediterranean fever susceptibility in the Japanese population. PMID: 23437051

SAA1 gene variants and childhood obesity in China. PMID: 24171731

Effects of serum amyloid protein A on influenza A virus replication and viral interactions with neutrophils. PMID: 33205458

Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. PMID: 25422367

Post-translational modification of amyloid a protein in patients with AA amyloidosis. PMID: 34787027

Influence of genotypes at SAA1 and SAA2 loci on the development and the length of latent period of secondary AA-amyloidosis in patients with rheumatoid arthritis. PMID: 10543406

Serum Proteomic Analysis Identifies SAA1, FGA, SAP, and CETP as New Biomarkers for Eosinophilic Granulomatosis With Polyangiitis. PMID: 35757752

SAA1 alpha/alpha alleles in Behçet's disease related amyloidosis. PMID: 17039260

Editorial comment on: inflammatory protein serum amyloid A1 marks a subset of conventional renal cell carcinomas with fatal outcome. PMID: 19747759

Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. PMID: 15170927

SAA1 is over-expressed in plasma of non small cell lung cancer patients with poor outcome after treatment with epidermal growth factor receptor tyrosine-kinase inhibitors. PMID: 22771314

SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects. PMID: 23940069

Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein. PMID: 29247043

Inflammatory protein serum amyloid A1 marks a subset of conventional renal cell carcinomas with fatal outcome. PMID: 19747761

Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region. PMID: 35664543

AA amyloidosis - Benefits and prospects of IL-6 inhibitors. PMID: 30132351

Associations of genetic polymorphisms of SAA1 with cerebral infarction. PMID: 23987125

Time-resolved fluorescent immunoassay-based combined detection of procalcitonin, C-reactive protein, heparin binding protein, and serum amyloid A1 to improve the diagnostic accuracy of early infection. PMID: 30338547

Discovery of Potential Serum Protein Biomarkers in Ankylosing Spondylitis Using Tandem Mass Tag-Based Quantitative Proteomics. PMID: 31917576

iTRAQ-based proteomic analysis of differentially expressed proteins in sera of seronegative and seropositive rheumatoid arthritis patients. PMID: 34812532

Identification of Genetic Associations and Functional Polymorphisms of SAA1 Gene Affecting Milk Production Traits in Dairy Cattle. PMID: 27610623

Serum amyloid A1 (SAA1) gene polymorphisms in Japanese patients with adult-onset Still's disease. PMID: 30544414

Chitinase-3-Like Protein 1, Serum Amyloid A1, C-Reactive Protein, and Procalcitonin Are Promising Biomarkers for Intracranial Severity Assessment of Traumatic Brain Injury: Relationship with Glasgow Coma Scale and Computed Tomography Volumetry. PMID: 31606503

The plasma peptides of sepsis. PMID: 32636717

FABP4 in Paneth cells regulates antimicrobial protein expression to reprogram gut microbiota. PMID: 36519446

Associations of SAA1 gene polymorphism with lipid lelvels and osteoporosis in Chinese women. PMID: 23522429

Significance of SAA1.3 allele genotype in Japanese patients with amyloidosis secondary to rheumatoid arthritis. PMID: 16219644

HDL proteome remodeling associates with COVID-19 severity. PMID: 34802985

Characterization of amyloid A protein in human secondary amyloidosis: the predominant deposition of serum amyloid A1. PMID: 7827140

Differential expression of serum amyloid A1 and A3 in bovine epithelia. PMID: 32378645

Rs12218 In SAA1 gene was associated with serum lipid levels. PMID: 23898911

Current perspectives on familial Mediterranean fever. PMID: 19339884

A novel polymorphism of human serum amyloid A protein, SAA1 gamma, is characterized by alanines at both residues 52 and 57. PMID: 8512321

Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. PMID: 18369528

C-reactive protein and serum amyloid a overexpression in lung tissues of chronic obstructive pulmonary disease patients: a case-control study. PMID: 23801879

A novel allelic variant of serum amyloid A, SAA1 gamma: genomic evidence, evolution, frequency, and implication as a risk factor for reactive systemic AA-amyloidosis. PMID: 7655463

Serum amyloid A3 is pro-atherogenic. PMID: 29175652

Expression of mouse acute-phase (SAA1.1) and constitutive (SAA4) serum amyloid A isotypes: influence on lipoprotein profiles. PMID: 10845870

Genetically determined recurrent fevers. PMID: 11544000

Human SAA1-derived amyloid deposition in cell culture: a consistent model utilizing human peripheral blood mononuclear cells and serum-free medium. PMID: 23461622

Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice. PMID: 28380028

Human serum amyloid A protein. Complete amino acid sequence of a new variant. PMID: 1546977

Robust Acute Pancreatitis Identification and Diagnosis: RAPIDx. PMID: 36988967

MFGE8, ALB, APOB, APOE, SAA1, A2M, and C3 as Novel Biomarkers for Stress Cardiomyopathy. PMID: 32695227

Tissue-specific regulation of the human acute-phase serum amyloid A genes, SAA1 and SAA2, by glucocorticoids in hepatic and epithelial cells. PMID: 12938239

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. PMID: 31441598

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human SAA1 Protein, N-His-SUMO [YHC65502]
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