RAD18 mediates DNA double-strand break-induced ubiquitination of chromatin protein. PMID: 33508099
Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma. PMID: 35459258
DNA repair protein Rad18 restricts LINE-1 mobility. PMID: 30367120
Analysis of the Mechanism of RAD18 in Glioma. PMID: 35367987
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer. PMID: 36228090
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells. PMID: 34624216
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases. PMID: 23756188
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer. PMID: 35895872
CARM1 regulates replication fork speed and stress response by stimulating PARP1. PMID: 33412112
RAD18 opposes transcription-associated genome instability through FANCD2 recruitment. PMID: 36480547
Impacts of arsenic on Rad18 and translesion synthesis. PMID: 36087615
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. PMID: 34508659
RAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p-DNA-PKcs. PMID: 35426246
The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes. PMID: 26384566
Knockdown of RAD18 inhibits glioblastoma development. PMID: 31081138
SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18. PMID: 31076518
Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis. PMID: 29683380
NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage. PMID: 30563767
LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms. PMID: 35849344
Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen. PMID: 30700555
UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization. PMID: 35313791
The Saccharomyces cerevisiae RAD18 gene encodes a protein that contains potential zinc finger domains for nucleic acid binding and a putative nucleotide binding sequence. PMID: 2970061
Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells. PMID: 22547805
RAD18 promotes colorectal cancer metastasis by activating the epithelial‑mesenchymal transition pathway. PMID: 32319669
RAD18 mediates resistance to ionizing radiation in human glioma cells. PMID: 24518219
Cooperation of replication protein A with the ubiquitin ligase Rad18 in DNA damage bypass. PMID: 19029798
Protein Dynamics in Complex DNA Lesions. PMID: 29547717
Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer. PMID: 34762666
High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression. PMID: 30798132
Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase. PMID: 28784724
Meiotic functions of RAD18. PMID: 21807948
Effect of DNA repair protein Rad18 on viral infection. PMID: 16710452
Functional Domain Mapping of Werner Interacting Protein 1 (WRNIP1). PMID: 35110507
Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. PMID: 26098514
A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein. PMID: 10747036
Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway. PMID: 20675655
RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. PMID: 22036607
RAD18 contributes to the migration and invasion of human cervical cancer cells via the interleukin‑1β pathway. PMID: 31432163
The structure and function of RAD6 and RAD18 DNA repair genes of Saccharomyces cerevisiae. PMID: 2698834
Pathological trans-lesion synthesis in cancer. PMID: 27462757
USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. PMID: 25961918
DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation. PMID: 15381075
[RAD18 regulates DNA damage tolerance]. PMID: 18341034
The human RAD18 gene product interacts with HHR6A and HHR6B. PMID: 10908344
Rad6/Rad18 Competes with DNA Polymerases η and δ for PCNA Encircling DNA. PMID: 31887036
RAD18 promotes the migration and invasion of esophageal squamous cell cancer via the JNK-MMPs pathway. PMID: 29306013
Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. PMID: 30567999
The role of WRNIP1 in genome maintenance. PMID: 28118071
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. PMID: 26883629
REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis. PMID: 35115490
High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer. PMID: 32356270
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. PMID: 18363965
DNA-damage tolerance through PCNA ubiquitination and sumoylation. PMID: 32726436
Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication. PMID: 21098111
c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks. PMID: 22456510
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. PMID: 23295675
Somatic hypermutation of immunoglobulin genes in Rad18 knockout mice. PMID: 28082021
DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress. PMID: 28835467
BRCTx is a novel, highly conserved RAD18-interacting protein. PMID: 15632077
RAD18 may function as a predictor of response to preoperative concurrent chemoradiotherapy in patients with locally advanced rectal cancer through caspase-9-caspase-3-dependent apoptotic pathway. PMID: 31033216
RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. PMID: 26549024
SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. PMID: 24958773
Elevated expression of Rad18 regulates melanoma cell proliferation. PMID: 22145991
PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments. PMID: 33242956
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. PMID: 22742833
Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure. PMID: 29859927
Integrating DNA replication with trans-lesion synthesis via Cdc7. PMID: 21150323
Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5. PMID: 19851286
Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination. PMID: 15509568
The Zn-finger of Saccharomyces cerevisiae Rad18 and its adjacent region mediate interaction with Rad5. PMID: 33570581
Rad18 is a transcriptional target of E2F3. PMID: 22391204
RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos. PMID: 26212134
REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18. PMID: 26795561
Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression. PMID: 35365623
ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins. PMID: 12776193
Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant. PMID: 31363085
WRN functions in a RAD18-dependent damage avoidance pathway. PMID: 17541157
RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure. PMID: 25675240
Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks. PMID: 21858012
NBS1 and multiple regulations of DNA damage response. PMID: 27068998
Physical and functional interaction between WRNIP1 and RAD18. PMID: 19556710
Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. PMID: 19068231
Control of DNA Damage Bypass by Ubiquitylation of PCNA. PMID: 32013080
Error-free DNA-damage tolerance in Saccharomyces cerevisiae. PMID: 26041265
Domains required for dimerization of yeast Rad6 ubiquitin-conjugating enzyme and Rad18 DNA binding protein. PMID: 9234711
DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. PMID: 25023518
Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. PMID: 10884424
Recruitment, loading, and activation of the Smc5-Smc6 SUMO ligase. PMID: 30600397
Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining. PMID: 25417706
SUMOylation regulates Rad18-mediated template switch. PMID: 19092928
DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1. PMID: 35339488
Chromatin Regulates Genome Targeting with Cisplatin. PMID: 28474855
Yeast DNA polymerase η possesses two PIP-like motifs that bind PCNA and Rad6-Rad18 with different specificities. PMID: 32932109
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. PMID: 19228710
Regulated expression and dynamic changes in subnuclear localization of mammalian Rad18 under normal and genotoxic conditions. PMID: 16098139
A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA. PMID: 23034805
A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci. PMID: 24107634
Functional relationships between Rad18 and WRNIP1 in vertebrate cells. PMID: 17077513
PUB-NChIP--"in vivo biotinylation" approach to study chromatin in proximity to a protein of interest. PMID: 23038767
Rad18 is required for DNA repair and checkpoint responses in fission yeast. PMID: 10473635
The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair. PMID: 8524274
The Neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc finger motifs. PMID: 8097557
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis. PMID: 21884979
[Effect of RAD18-siRNA on proliferation and chemotherapy sensitivity of human esophageal squamous cell carcinoma ECA-109 cells]. PMID: 27868409
Role for RAD18 in homologous recombination in DT40 cells. PMID: 16923963
Molecular determinants of polyubiquitin recognition by continuous ubiquitin-binding domains of Rad18. PMID: 25756347
Symmetry and asymmetry of the RING-RING dimer of Rad18. PMID: 21549715
Tumor-associated macrophages contribute to cisplatin resistance via regulating Pol η-mediated translesion DNA synthesis in ovarian cancer., PMID:40437303
Genome-Wide Identification of ATL Gene Family in Wheat and Their Expression Analysis in Response to Salt Stress., PMID:40364335
Beyond the Transcript: Translating Non-Coding RNAs and Their Impact on Cellular Regulation., PMID:40361481
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells., PMID:40025006
MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis., PMID:40016217
Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy., PMID:39905312
Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency., PMID:39886906
RIOK1: A Novel Oncogenic Driver in Hepatocellular Carcinoma., PMID:39865406
In and out of Replication Stress: PCNA/RPA1-Based Dynamics of Fork Stalling and Restart in the Same Cell., PMID:39859385
Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination., PMID:39858544
Rad5 and Ubc4 directly ubiquitinate PCNA at Lys164 in vitro., PMID:39826694
The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egress., PMID:39628457
RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA., PMID:39580855
DNA damage repair factor Rad18 controls virulence partially via transcriptional suppression of genes HWP1 and ECE1 in Candida albicans., PMID:39573927
ADAR1 enhances tumor proliferation and radioresistance in non-small cell lung cancer by interacting with Rad18., PMID:39570561
Somatic gene mutations involved in DNA damage response/Fanconi anemia signaling are tissue- and cell-type specific in human solid tumors., PMID:39421870
MELATONIN ENHANCES TEMOZOLOMIDE-INDUCED APOPTOSIS IN GLIOBLASTOMA AND NEUROBLASTOMA CELLS., PMID:39396175
Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork., PMID:39360622
Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells., PMID:39291733
Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response., PMID:39180588
RAD18- and BRCA1-dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir., PMID:39169841
A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates., PMID:39121224
Identification of Key Genes Associated with Polycystic Ovarian Syndrome and Endometrial and Ovarian Cancer through Bioinformatics., PMID:39091436
PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis., PMID:39043663
A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells., PMID:38943334
Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction., PMID:38907034
Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity., PMID:38885312
RAD18 directs DNA double-strand break repair by homologous recombination to post-replicative chromatin., PMID:38884202
USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase., PMID:38802791
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis., PMID:38769345
RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair., PMID:38719812
Adaptive use of error-prone DNA polymerases provides flexibility in genome replication during tumorigenesis., PMID:38651239
Neil 1 deficiency facilitates chemoresistance through upregulation of RAD18 expression in ovarian cancer stem cells., PMID:38636303
RAS-RAF-miR-296-3p signaling axis increases Rad18 expression to augment radioresistance in pancreatic and thyroid cancers., PMID:38604313
CPPs-modified chitosan as permeability-enhancing chemotherapeutic combined with gene therapy nanosystem by thermosensitive hydrogel for the treatment of osteosarcoma., PMID:38561118
Role of Rad18 in B cell activation and lymphomagenesis., PMID:38528023
ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability., PMID:38467834
Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression., PMID:38460179
Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins., PMID:38448672
Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma., PMID:38438348
Rad6, a ubiquitin conjugator required for insect-pathogenic lifestyle, UV damage repair, and genomic expression of Beauveria bassiana., PMID:38246123
TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis., PMID:38175749
Current insights into the oncogenic roles of lncRNA LINC00355., PMID:38125763
Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription., PMID:38073330
Exploring RAD18-dependent replication of damaged DNA and discontinuities: A collection of advanced tools., PMID:38072328
Decreasing predictable DNA off-target effects and narrowing editing windows of adenine base editors by fusing human Rad18 protein variant., PMID:37848112
Structural insights into Rad18 targeting by the SLF1 BRCT domains., PMID:37748650
High-throughput screening of the Saccharomyces cerevisiae genome for 2-amino-3-methylimidazo [4,5-f] quinoline resistance identifies colon cancer-associated genes., PMID:37738679
The DDUP protein encoded by the DNA damage-induced CTBP1-DT lncRNA confers cisplatin resistance in ovarian cancer., PMID:37633920
L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab., PMID:37557179
For research use only. Not for human or drug use.
