NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment. PMID: 30362654
Skin adnexal carcinoma with BRD3-NUTM2B fusion. PMID: 34296453
BRD3-NUTM1-expressing NUT carcinoma of lung on endobronchial ultrasound-guided transbronchial needle aspiration cytology, a diagnostic pitfall. PMID: 34672128
Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. PMID: 37043564
The BET family in immunity and disease. PMID: 33462181
Cutaneous Primary NUT Carcinoma With BRD3-NUTM1 Fusion. PMID: 34482332
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. PMID: 32895492
BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs. PMID: 32324495
BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation. PMID: 35665862
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. PMID: 34813359
Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC. PMID: 34605158
BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis. PMID: 28733670
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. PMID: 31969702
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. PMID: 27274052
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. PMID: 32193360
[Brd3 promotes IL-6 production via enhancing acetylase CBP recruitment and histone 3 acetylation within IL6 promoter]. PMID: 27667451
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. PMID: 21536911
Long noncoding RNA NEAT1 decreases polycystic ovary syndrome progression via the modulation of the microRNA-324-3p and BRD3 axis. PMID: 36040750
BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. PMID: 29240787
Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. PMID: 28045112
Author Correction: Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. PMID: 33262417
The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. PMID: 29567837
Reply to: Expanding the Spectrum of Primary Cutaneous Carcinoma With BRD3-NUTM1 Fusion. PMID: 34469332
Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants. PMID: 35468861
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. PMID: 34520194
BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors. PMID: 33393503
[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]. PMID: 12600283
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines. PMID: 37084596
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. PMID: 33592170
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. PMID: 26035625
ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma. PMID: 34951647
Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma. PMID: 33509905
Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression. PMID: 30786900
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma. PMID: 33016928
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. PMID: 28805820
Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes. PMID: 27158652
Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. PMID: 35622893
BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. PMID: 27008626
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. PMID: 18406326
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. PMID: 28805822
BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia. PMID: 35958877
NUT midline carcinoma. PMID: 20951314
Three calcium-sensitive genes, fus, brd3 and wdr5, are highly expressed in neural and renal territories during amphibian development. PMID: 23287019
Pharmacological Modulation of BET Family in Sepsis. PMID: 33776776
Phospho-BRD4: transcription plasticity and drug targeting. PMID: 27769352
BET proteins: Biological functions and therapeutic interventions. PMID: 36739915
Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3. PMID: 21555453
Case report of a pan-cytokeratin negative NUT midline carcinoma of pulmonary origin, a BRD3-NUT variant: Challenges in cytomorphologic presentation. PMID: 37021735
Dihydropyridine Lactam Analogs Targeting BET Bromodomains. PMID: 34932262
NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics. PMID: 35372003
Identification of photocrosslinking peptide ligands by mRNA display. PMID: 37258712
Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor. PMID: 37269669
Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets. PMID: 36793283
A 33-Year-Old Man With Chest Pain. PMID: 35000716
BRD4: New hope in the battle against glioblastoma. PMID: 37061146
Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis. PMID: 15261828
Small-Molecule Targeting of BET Proteins in Cancer. PMID: 27451123
Bromodomains as therapeutic targets in cancer. PMID: 23543289
Targeting the BET family for the treatment of leukemia. PMID: 24811781
Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination. PMID: 15128596
Pathogenesis of NUT midline carcinoma. PMID: 22017582
Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer., PMID:40407591
Inhibition of bromodomain and extra-terminal (BET) proteins with JQ1 exacerbates acetaminophen-induced hepatotoxicity by altering detoxification pathways and oxidative stress responses., PMID:40157625
Challenging diagnosis in pulmonary nut carcinoma: A report of two cases with different histopathologic and molecular features and a novel NUTM1::SPECC1 gene fusion., PMID:40152114
Advancing Understanding and Therapeutic Strategies for NUT Sarcomas: Comprehensive Review of the Literature and Two Cases., PMID:40070529
Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates., PMID:40046450
Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma., PMID:40011918
MAD::NUT Fusion Sarcoma: A Sarcoma Class With NUTM1, NUTM2A, and NUTM2G Fusions and Possibly Distinctive Subtypes., PMID:39921028
Gene Fusion-Driven Cutaneous Adnexal Neoplasms: An Updated Review Emphasizing Molecular Characteristics., PMID:39912629
Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies., PMID:39905380
Ku70 targets BRD3-MYC/Cyclin D1 axis to drive hepatocellular carcinoma progression., PMID:39743013
Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor., PMID:39681044
MiR-200a-3p Attenuates Neuropathic Pain by Suppressing the Bromodomain-Containing Protein 3-Nuclear Factor-κB Pathway., PMID:39651616
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2., PMID:39396041
OsFAD1-OsMYBR22 modulates clustered spikelet through regulating BRD3 in rice., PMID:39279451
Identification of Novel Bromodomain-Containing Protein 4 (BRD4) Binders through 3D Pharmacophore-Based Repositioning Screening Campaign., PMID:39274873
Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma., PMID:39273015
BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression., PMID:39164524
Intrinsic signaling pathways modulate targeted protein degradation., PMID:38956052
mRNA Display in Cell Lysates Enables Identification of Cyclic Peptides Targeting the BRD3 Extraterminal Domain., PMID:38899853
Primary Cutaneous NUT Carcinoma: Clinicopathologic and Genetic Study of 4 Cases., PMID:38708710
BRD2-specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis-induced C57BL/6 male mice., PMID:38600628
The Pharmacogenetic Variability Associated with the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Healthy Chinese Subjects: A National Multicenter Exploratory Study., PMID:38553322
Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer., PMID:38494600
Primary cutaneous NUT carcinoma with BRD4::NUTM1 fusion., PMID:38481096
Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition., PMID:38452087
Clinicopathological molecular characterizations of sinonasal NUT carcinoma: a report of two cases and a literature review., PMID:38239638
BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing., PMID:38226395
BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer., PMID:38216082
Genetic correlation, shared loci, but no causality between bipolar disorder and inflammatory bowel disease: A genome-wide pleiotropic analysis., PMID:38154582
BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts., PMID:38137409
Bromodomain Proteins Epigenetically Regulate the Mitotically Associated lncRNA MANCR in Triple Negative Breast Cancer Cells., PMID:38073442
High-Grade Spindle Cell Sarcoma of the Scalp With an MGA::NUTM1 Gene Fusion in a Pediatric Patient., PMID:38055974
mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome., PMID:37992806
A Phase I/II Study of GSK525762 Combined with Fulvestrant in Patients with Hormone Receptor-positive/HER2-negative Advanced or Metastatic Breast Cancer., PMID:37992310
Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins., PMID:37629054
Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors., PMID:37628849
BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3., PMID:37594294
Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey., PMID:37505808
Uncovering the Kinetic Characteristics and Degradation Preference of PROTAC Systems with Advanced Theoretical Analyses., PMID:37388700
Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity., PMID:37289649
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins., PMID:37269828
Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor., PMID:37269669
Identification of photocrosslinking peptide ligands by mRNA display., PMID:37258712
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines., PMID:37084596
The expanding universe of NUTM1 fusions in pediatric cancer., PMID:37082775
Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra-Terminal Domain., PMID:37071570
BRD4: New hope in the battle against glioblastoma., PMID:37061146
BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications., PMID:37049806
Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis., PMID:37043564
Case report of a pan-cytokeratin negative NUT midline carcinoma of pulmonary origin, a BRD3-NUT variant: Challenges in cytomorphologic presentation., PMID:37021735
For research use only. Not for human or drug use.
