Catalog No.
YHK89301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys117-His190
Predicted molecular weight
20.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q75N03
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CBLL1, RING-type E3 ubiquitin transferase Hakai, E3 ubiquitin-protein ligase Hakai, RING finger protein 188, c-Cbl-like protein 1, HAKAI, RNF188, Casitas B-lineage lymphoma-transforming sequence-like protein 1
The role of m6A modification in the biological functions and diseases. PMID: 33611339
Expression and clinical prognostic value of m6A RNA methylation modification in breast cancer. PMID: 33926554
CBLL1 is highly expressed in non-small cell lung cancer and promotes cell proliferation and invasion. PMID: 31124298
Upregulation of CBLL1 in rat brain cortex after lipopolysaccharide treated. PMID: 23160791
RNA m6A Methylation Regulators Multi-Omics Analysis in Prostate Cancer. PMID: 34899855
m6A regulator-mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis. PMID: 33724691
Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication. PMID: 21191016
Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis. PMID: 32190002
The Role of m6A RNA Methylation in Cancer: Implication for Nature Products Anti-Cancer Research. PMID: 35784761
Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/CBLL1 axis in non-small cell lung cancer cells. PMID: 31646569
Comprehensive analysis of the m6A-related molecular patterns and diagnostic biomarkers in osteoporosis. PMID: 36034449
Study on the prognosis, immune and drug resistance of m6A-related genes in lung cancer. PMID: 36261786
Diagnosis, clustering, and immune cell infiltration analysis of m6A-related genes in patients with acute myocardial infarction-a bioinformatics analysis. PMID: 35693610
Human mesenchymal stem cell homing induced by SKOV3 cells. PMID: 28337256
Wilms' tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences. PMID: 34582888
Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. PMID: 36733939
Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis. PMID: 36685841
Biological influence of Hakai in cancer: a 10-year review. PMID: 22349934
Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma. PMID: 35223847
Hacking RNA: Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF. PMID: 19855157
Genome-wide identification of alternative splicing associated with histone deacetylase inhibitor in cutaneous T-cell lymphomas. PMID: 36147491
N6-methyladenosine modulation classes and immune microenvironment regulation in ischemic stroke. PMID: 36762188
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop. PMID: 34764728
Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease. PMID: 36266428
Landscape analysis of m6A modification regulators related biological functions and immune characteristics in myasthenia gravis. PMID: 36864526
Expression patterns of eight RNA-modified regulators correlating with immune infiltrates during the progression of osteoarthritis. PMID: 37006267
m6A Regulator-mediated RNA Methylation Modulates Immune Microenvironment of Hepatitis B Virus-related Acute Liver Failure. PMID: 37256461
The development of a novel signature based on the m6A RNA methylation regulator-related ceRNA network to predict prognosis and therapy response in sarcomas. PMID: 36313417
Hakai, an E3-ligase for E-cadherin, stabilizes δ-catenin through Src kinase. PMID: 28069439
RNA interference screen for human genes associated with West Nile virus infection. PMID: 18690214
Effects of N6-Methyladenosine Regulators on LAG3 and Immune Infiltrates in Lung Adenocarcinoma. PMID: 36051357
Microarray profiling of genes differentially expressed during erythroid differentiation of murine erythroleukemia cells. PMID: 16258242
Diagnostic signature, subtype classification, and immune infiltration of key m6A regulators in osteomyelitis patients. PMID: 36544487
Hakai overexpression effectively induces tumour progression and metastasis in vivo. PMID: 29472634
Human m6A-mRNA and lncRNA epitranscriptomic microarray reveal function of RNA methylation in hemoglobin H-constant spring disease. PMID: 34650160
PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function. PMID: 33573690
Analysis of m6A modification regulators in the substantia nigra and striatum of MPTP-induced Parkinson's disease mice. PMID: 36209975
Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. PMID: 22252131
E-cadherin and Hakai: signalling, remodeling or destruction? PMID: 11944035
Identification of RNA N6-methyladenosine regulation in epilepsy: Significance of the cell death mode, glycometabolism, and drug reactivity. PMID: 36468034
Novel roles of hakai in cell proliferation and oncogenesis. PMID: 19535458
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion. PMID: 22051109
Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress. PMID: 29356040
miR-203 regulates cell proliferation through its influence on Hakai expression. PMID: 23285092
Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI. PMID: 30111817
Proteomic Analysis of the E3 Ubiquitin-Ligase Hakai Highlights a Role in Plasticity of the Cytoskeleton Dynamics and in the Proteasome System. PMID: 28675930
Hakai acts as a coregulator of estrogen receptor alpha in breast cancer cells. PMID: 20608937
Gene signature of m6A-related targets to predict prognosis and immunotherapy response in ovarian cancer. PMID: 36048273
Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure. PMID: 25074933
Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes. PMID: 18624796
Novel gene markers of immunosuppressive chemicals in mouse lymph node assay. PMID: 21621594
For research use only. Not for human or drug use.
