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Recombinant Human AMOTL2/LCCP Protein, N-His

Catalog #:   YHK88501 Specific References (118) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q9Y2J4
Protein length: Ser540-Asp653
Overview

Catalog No.

YHK88501

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Ser540-Asp653

Predicted molecular weight

15.36 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9Y2J4

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

LCCP, AMOTL2, Angiomotin-like protein 2, Leman coiled-coil protein, KIAA0989

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human AMOTL2/LCCP protein
References

AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches. PMID: 34165350

AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization. PMID: 34036399

FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats. PMID: 35563891

AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. PMID: 32950569

AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation. PMID: 34323359

AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. PMID: 34404733

IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment. PMID: 30794467

AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells. PMID: 23911299

Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. PMID: 17293535

The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. PMID: 22362771

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis. PMID: 33707576

Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle. PMID: 23525008

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. PMID: 25080976

AmotL2 integrates polarity and junctional cues to modulate cell shape. PMID: 28790366

AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. PMID: 24806444

Myocyte enhancer factor 2D promotes hepatocellular carcinoma through AMOTL2/YAP signaling that inhibited by luteolin. PMID: 35698637

The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. PMID: 28842668

Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. PMID: 21937427

Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness. PMID: 25998128

Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension. PMID: 32166015

mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease. PMID: 34202571

Hypoxic Tumor-Derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer. PMID: 32942233

Angiomotin-like 2 interacts with and negatively regulates AKT. PMID: 28368415

Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. PMID: 26598551

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2. PMID: 37131806

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. PMID: 21832154

Angiomotin Family Members: Oncogenes or Tumor Suppressors? PMID: 28656002

The physiological role of Motin family and its dysregulation in tumorigenesis. PMID: 29650031

Suppression of YAP safeguards human naïve pluripotency. PMID: 36398796

Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma. PMID: 33658392

Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. PMID: 22813598

Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway. PMID: 32385107

The role of Motin family proteins in tumorigenesis-an update. PMID: 36973516

Podosomes in muscle cells and their role in the remodeling of neuromuscular postsynaptic machinery. PMID: 25012928

Angiomotin'g YAP into the nucleus for cell proliferation and cancer development. PMID: 24003252

The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap. PMID: 34761265

Evaluation of the role of kefir in management of non-alcoholic steatohepatitis rat model via modulation of NASH linked mRNA-miRNA panel. PMID: 36604518

Connecting physical cues and tissue patterning. PMID: 26473744

Overlooked long-chain chlorinated paraffin (LCCP) contamination in foodstuff from China. PMID: 34467914

How Low-Carbon Pilots Affect Chinese Urban Energy Efficiency: An Explanation from Technological Progress. PMID: 36497638

Effectiveness of Lilly Connected Care Program (LCCP) App-Based Diabetes Education for Patients With Type 2 Diabetes Treated With Insulin: Retrospective Real-World Study. PMID: 32141838

How to Achieve Carbon Neutrality in Cities? Evidence from China's Low-Carbon Cities Development. PMID: 36767488

Evaluation of China's low-carbon city pilot policy: Evidence from 210 prefecture-level cities. PMID: 34618870

Assessing the low-carbon city pilot policy on carbon emission from consumption and production in China: how underlying mechanism and spatial spillover effect? PMID: 35610453

Effectiveness of the Family Portal Function on the Lilly Connected Care Program (LCCP) for Patients With Type 2 Diabetes: Retrospective Cohort Study With Propensity Score Matching. PMID: 33544081

Has China's Low-Carbon City Construction Enhanced the Green Utilization Efficiency of Urban Land? PMID: 36011480

The impact of low-carbon city pilot policy on green total-factor productivity in China's cities. PMID: 36334204

Does Low-Carbon City Pilot Policy Alleviate Urban Haze Pollution? Empirical Evidence from a Quasi-Natural Experiment in China. PMID: 34769802

Effectiveness of the Lilly Connected Care Program in Improving Glycemic Management Among Patients With Type 2 Diabetes in China: Retrospective Real-world Study. PMID: 37097724

Does low-carbon city pilot affect the enterprise competitiveness in China? Based on a staggered difference-in-difference model. PMID: 36571678

Impact of Low-Carbon City Policy on Enterprise Investment Efficiency: Based on the Heterogeneity of Chinese Urban Culture. PMID: 36193413

GREEN-MAC-LCCP: a tool for assessing the life cycle climate performance of MAC systems. PMID: 20812721

The Low-Carbon Policy and Urban Green Total Factor Energy Efficiency: Evidence from a Spatial Difference-in-Difference Method. PMID: 36834192

Does the low-carbon city pilot policy work in China? A company-level analysis based on the PSM-DID model. PMID: 36933536

Pathological characteristics of light chain crystalline podocytopathy. PMID: 36581019

Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery. PMID: 32263910

Can low-carbon city construction reduce carbon intensity?Empirical evidence from low-carbon city pilot policy in China. PMID: 36736083

Environmental Risks of Medium-Chain Chlorinated Paraffins (MCCPs): A Review. PMID: 29791144

Medium- and long-chain chlorinated paraffins in air: A review of levels, physicochemical properties, and analytical considerations. PMID: 35779735

Risk assessment of chlorinated paraffins in feed and food. PMID: 32874241

Evaluation of the Effectiveness of a Multimodal Complementary Medicine Program for Improving the Quality of Life of Cancer Patients during Adjuvant Radiotherapy and/or Chemotherapy or Outpatient Aftercare. PMID: 28472802

The personal development tutor role: an exploration of student and lecturer experiences and perceptions of that relationship. PMID: 24467865

Novel metal sites in protein structures. PMID: 8994881

Polyelectrolyte-grafted anion exchangers with hydrophilic intermediate layers for ion chromatography. PMID: 36166883

Seasonal variation of short-, medium- and long-chain chlorinated paraffin distribution in Belgian indoor dust. PMID: 36370602

Advances in kinetic protein crystallography. PMID: 16129597

Short-, medium-, and long-chain chlorinated paraffins in South African indoor dust and cat hair. PMID: 31473532

Chlorinated Paraffins in Human Milk from Urban Sites in China, Sweden, and Norway. PMID: 32101003

hsa-mir-483-3p modulates delayed breast cancer recurrence., PMID:39753688

E3 ubiquitin ligase ITCH-mediated proteasomal degradation of WBP2 sensitizes breast cancer cells to chemotherapy through restraining AMOTL2/c-JUN axis., PMID:39709035

Changes in AmotL2 Expression in Cells of the Human Enteral Nervous System in Oxaliplatin-Induced Enteric Neuropathy., PMID:39335466

Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling., PMID:39027975

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway., PMID:38956029

Role of angiomotin family members in human diseases (Review)., PMID:38766307

Angiomotin family proteins in the Hippo signaling pathway., PMID:38760875

The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells., PMID:38717123

Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction., PMID:38299356

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2., PMID:38126343

Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis., PMID:37994470

Rapid Regulation of Cardiomyocytes Adhesion on Substrates with Varied Modulus via Mechanical Cues., PMID:37956199

Modulation of E-Cadherin Function through the AmotL2 Isoforms Promotes Ameboid Cell Invasion., PMID:37443716

The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms., PMID:39195920

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2., PMID:37131806

The role of Motin family proteins in tumorigenesis-an update., PMID:36973516

Evaluation of the role of kefir in management of non-alcoholic steatohepatitis rat model via modulation of NASH linked mRNA-miRNA panel., PMID:36604518

Suppression of YAP safeguards human naïve pluripotency., PMID:36398796

Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries., PMID:36152675

Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway., PMID:35941675

Myocyte enhancer factor 2D promotes hepatocellular carcinoma through AMOTL2/YAP signaling that inhibited by luteolin., PMID:35698637

FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats., PMID:35563891

Copper stress impairs angiogenesis and lymphangiogenesis during zebrafish embryogenesis by down-regulating pERK1/2-foxm1-MMP2/9 axis and epigenetically regulating ccbe1 expression., PMID:35034208

The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap., PMID:34761265

Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity., PMID:34515990

AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation., PMID:34404733

AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation., PMID:34323359

mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease., PMID:34202571

AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches., PMID:34165350

AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization., PMID:34036399

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis., PMID:33707576

Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma., PMID:33658392

AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells., PMID:32950569

Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway., PMID:32385107

IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment., PMID:30794467

Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases., PMID:30708959

Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling., PMID:30266805

The physiological role of Motin family and its dysregulation in tumorigenesis., PMID:29650031

ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation., PMID:29177764

TAZ responds to fluid shear stress to regulate the cell cycle., PMID:29143545

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade., PMID:28877210

The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching., PMID:28842668

AmotL2 integrates polarity and junctional cues to modulate cell shape., PMID:28790366

Angiomotin Family Members: Oncogenes or Tumor Suppressors?, PMID:28656002

Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy., PMID:28441737

Angiomotin-like 2 interacts with and negatively regulates AKT., PMID:28368415

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin., PMID:27521426

Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition., PMID:26598551

Connecting physical cues and tissue patterning., PMID:26473744

Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish., PMID:26335201

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human AMOTL2/LCCP Protein, N-His [YHK88501]
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