Catalog No.
YHD38301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr316-Gln403
Predicted molecular weight
22.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20264
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
POU3F3, Oct-8, OTF-8, BRN1, POU domain, class 3, transcription factor 3, Brain-1, Octamer-binding transcription factor 8, OTF8, Brn-1, Brain-specific homeobox/POU domain protein 1, Octamer-binding protein 8
LncRNA POU3F3 promotes melanoma cell proliferation by downregulating lncRNA MEG3. PMID: 35201451
LncRNA POU3F3 Contributes to Dacarbazine Resistance of Human Melanoma Through the MiR-650/MGMT Axis. PMID: 33816296
POU3F3-related disorder: Defining the phenotype and expanding the molecular spectrum. PMID: 37165752
LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5. PMID: 34352801
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis. PMID: 35264092
Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion. PMID: 29906746
LncRNA POU3F3 promotes cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1. PMID: 30602452
LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9. PMID: 30843771
Effect of Linc-POU3F3 on radiotherapy resistance and cancer stem cell markers of esophageal cancer cells. PMID: 34275926
Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p. PMID: 32615948
Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma. PMID: 25445282
Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson's Disease. PMID: 32236821
Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1. PMID: 30474879
Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer. PMID: 26510906
Tumor-Secreted Exosomal lncRNA POU3F3 Promotes Cisplatin Resistance in ESCC by Inducing Fibroblast Differentiation into CAFs. PMID: 32637576
Linc-POU3F3 promotes cell proliferation in gastric cancer via increasing T-reg distribution. PMID: 26807174
Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. PMID: 32958671
Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium. PMID: 19743445
De Novo Variants Disturbing the Transactivation Capacity of POU3F3 Cause a Characteristic Neurodevelopmental Disorder. PMID: 31303265
scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3. PMID: 33444816
Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3. PMID: 28338200
Linc-POU3F3 is overexpressed in in-stent restenosis patients and induces VSMC phenotypic transformation via POU3F3/miR-449a/KLF4 signaling pathway. PMID: 31396351
Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. PMID: 25608466
Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. PMID: 24631494
SP1-mediated long noncoding RNA POU3F3 accelerates the cervical cancer through miR-127-5p/FOXD1. PMID: 31252264
Coexistence of severe developmental delay, epilepsy, and hemangioma in Snijders Blok-Fisher syndrome suggests the presence of a POU3F3-related SNIBFIS endophenotype: A case report. PMID: 33645921
A de novo POU3F3 Deletion in a Boy with Intellectual Disability and Dysmorphic Features. PMID: 24550763
Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. PMID: 29877572
Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2. PMID: 9457692
Regulatory de novo mutations underlying intellectual disability. PMID: 36854624
Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle. PMID: 27420727
[Retracted] Long noncoding RNA UCID sponges miR‑152‑3p to promote colorectal cancer cell migration and invasion via the Wnt/β‑catenin signaling pathway. PMID: 36960872
Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. PMID: 27003440
Kir2.1 is important for efficient BMP signaling in mammalian face development. PMID: 29571612
The long non-coding RNA Dali is an epigenetic regulator of neural differentiation. PMID: 25415054
Evaluation of Serum Exosomal lncRNAs as Diagnostic and Prognostic Biomarkers for Esophageal Squamous Cell Carcinoma. PMID: 33116835
Sequential pattern of sublayer formation in the paleocortex and neocortex. PMID: 32002665
Sexually dimorphic transcriptional programs of early-phase response in regenerating peripheral nerves. PMID: 35983069
Neurogenic gene regulatory pathways in the sea urchin embryo. PMID: 26657764
POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex. PMID: 22892427
[Renal development and its molecular mechanism]. PMID: 15926494
Multiomics Analyses Reveal Sex Differences in Mouse Renal Proximal Subsegments. PMID: 36758122
Identification of Differentially Expressed Genes and Prediction of Expression Regulation Networks in Dysfunctional Endothelium. PMID: 36140731
LncRNA PANTR1 is Associated with Poor Prognostic and Suppresses Apoptosis in Glioma. PMID: 36861062
A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification. PMID: 29395907
Transcriptional characterization of conjunctival melanoma identifies the cellular tumor microenvironment and prognostic gene signatures. PMID: 33046735
Deep intronic NIPBL de novo mutations and differential diagnoses revealed by whole genome and RNA sequencing in Cornelia de Lange syndrome patients. PMID: 35842780
A Novel CpG Methylation Risk Indicator for Predicting Prognosis in Bladder Cancer. PMID: 34540821
Three Circulating LncRNA Predict Early Progress of Esophageal Squamous Cell Carcinoma. PMID: 27855375
Hepatocyte nuclear factor 1β controls nephron tubular development. PMID: 23362349
DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex. PMID: 30329130
Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants. PMID: 31796600
Biocompatibility evaluation of a 3D-bioprinted alginate-GelMA-bacteria nanocellulose (BNC) scaffold laden with oriented-growth RSC96 cells. PMID: 34579912
Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw. PMID: 33905525
Global methylation profiling for risk prediction of prostate cancer. PMID: 22589488
Deconvolution of Transcriptional Networks in Post-Traumatic Stress Disorder Uncovers Master Regulators Driving Innate Immune System Function. PMID: 29101382
Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma. PMID: 25366138
Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. PMID: 19527706
Long Non-Coding RNA PANTR1 is Associated with Poor Prognosis and Influences Angiogenesis and Apoptosis in Clear-Cell Renal Cell Cancer. PMID: 32397610
Transcriptional regulation of cortical neuron migration by POU domain factors. PMID: 11859196
Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex. PMID: 20484645
Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4. PMID: 26951672
The Optimedin gene is a downstream target of Pax6. PMID: 16115881
GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome. PMID: 29168008
Long noncoding RNA, tissue differentiation-inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma. PMID: 26833746
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. PMID: 21692051
Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas. PMID: 18421211
Structure and evolution of four POU domain genes expressed in mouse brain. PMID: 1565620
RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome. PMID: 27295951
Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. PMID: 15872005
Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development. PMID: 36521641
Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation. PMID: 25243889
Dewaxed ECM: A simple method for analyzing cell behaviour on decellularized extracellular matrices. PMID: 23172824
Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. PMID: 12925600
Cooperative function of POU proteins and SOX proteins in glial cells. PMID: 9632656
Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. PMID: 11997177
Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior. PMID: 16900213
Characterization of enhancers active in the mouse embryonic cerebral cortex suggests Sox/Pou cis-regulatory logics and heterogeneity of cortical progenitors. PMID: 23720416
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. PMID: 17141158
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. PMID: 12130536
Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity. PMID: 17568789
Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. PMID: 15465489
Microarray analysis of striatal embryonic stem cells induced to differentiate by ensheathing cell conditioned media. PMID: 18351659
Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. PMID: 18697905
Expression of Sox11 and Brn transcription factors during development and following transient forebrain ischemia in the rat. PMID: 18261853
An octamer-binding site is crucial for the activity of an enhancer active at the embryonic met-/mesencephalic junction. PMID: 10473120
Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region. PMID: 25747816
Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6. PMID: 17660295
High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. PMID: 15249135
DNA methylation-based patterns for early diagnostic prediction and prognostic evaluation in colorectal cancer patients with high tumor mutation burden. PMID: 36713578
The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination. PMID: 15713637
Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. PMID: 19424592
For research use only. Not for human or drug use.
