Catalog No.
YHG48001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met10-Asp225
Predicted molecular weight
26.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13310
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activated-platelet protein 1, APP-1, PABP4, PABPC4, APP1, Inducible poly(A)-binding protein, PABP-4, Polyadenylate-binding protein 4, Poly(A)-binding protein 4, iPABP
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy. PMID: 34612687
A novel long non-coding RNA RP11-286H15.1 represses hepatocellular carcinoma progression by promoting ubiquitination of PABPC4. PMID: 33259899
LncRNA PCIR Is an Oncogenic Driver via Strengthen the Binding of TAB3 and PABPC4 in Triple Negative Breast Cancer. PMID: 34012913
Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. PMID: 37059182
MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty. PMID: 33744966
Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. PMID: 24469397
Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes. PMID: 36067236
Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis. PMID: 22884093
Gender-specific association between the cytoplasmic poly(A) binding protein 4 rs4660293 single nucleotide polymorphism and serum lipid levels. PMID: 26005159
LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma. PMID: 37009826
Immunohistochemical analysis of medullary breast carcinoma autoantigens in different histological types of breast carcinomas. PMID: 23181716
The long non-coding RNA MEG3 plays critical roles in the pathogenesis of cholesterol gallstone. PMID: 33665015
Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes. PMID: 20943973
miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features. PMID: 30530815
Identification and screening of host proteins interacting with ORFV-ORF047 protein. PMID: 33499896
The translational functions of embryonic poly(A)-binding protein during gametogenesis and early embryo development. PMID: 31408254
A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. PMID: 11374897
Strap associates with Csde1 and affects expression of select Csde1-bound transcripts. PMID: 30138317
Translational regulation in the brain by TDP-43 phase separation. PMID: 34427634
Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation. PMID: 26310847
Gene variants of coagulation related proteins that interact with SARS-CoV-2. PMID: 33730015
Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success. PMID: 23938467
Genome-wide search identified DNA methylation sites that regulate the metabolome. PMID: 37274792
Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma. PMID: 27161446
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein. PMID: 25768928
[Cytoplasmic RNP complexes in Xenopus oocytes]. PMID: 21089635
Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation. PMID: 33580194
Evidence of differential allelic effects between adolescents and adults for plasma high-density lipoprotein. PMID: 22530058
Uncovering potential lncRNAs and nearby mRNAs in systemic lupus erythematosus from the Gene Expression Omnibus dataset. PMID: 31755746
Screening of differentially expressed proteins from syncytiotrophoblast for severe early-onset preeclampsia in women with gestational diabetes mellitus using tandem mass tag quantitative proteomics. PMID: 30404616
Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. PMID: 31152063
Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2. PMID: 32935103
Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation. PMID: 22497250
An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins. PMID: 22896784
Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression. PMID: 26911678
Effect of Experimental Ischemic Stroke and PGE2 EP1 Selective Antagonism in Alzheimer's Disease Mouse Models. PMID: 31985468
Human testis expresses a specific poly(A)-binding protein. PMID: 11328870
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. PMID: 15713657
Embryonic poly(A)-binding protein stimulates translation in germ cells. PMID: 21518916
Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development. PMID: 25844599
Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. PMID: 16418480
Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades. PMID: 16418484
Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation. PMID: 17938241
RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB. PMID: 14717712
Human PABP binds AU-rich RNA via RNA-binding domains 3 and 4. PMID: 28359799
Paxillin and embryonic PolyAdenylation Binding Protein (ePABP) engage to regulate androgen-dependent Xenopus laevis oocyte maturation - A model of kinase-dependent regulation of protein expression. PMID: 12489691
Characterization of the poly(A) binding proteins expressed during oogenesis and early development of Xenopus laevis. PMID: 12846786
Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract. PMID: 16214267
Alzheimer-associated APP+1 transgenic mice: frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology. PMID: 11274061
A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts. PMID: 15630085
An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. PMID: 23300856
Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells. PMID: 21940797
Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. PMID: 15676026
Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. PMID: 9030741
For research use only. Not for human or drug use.
