Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis. PMID: 32072193
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease. PMID: 35844803
AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes. PMID: 33747723
A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases. PMID: 31783032
Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia. PMID: 35370705
Akap1 Regulates Vascular Function and Endothelial Cells Behavior. PMID: 29335250
AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes. PMID: 32108342
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. PMID: 30093535
miR-199b-5p-AKAP1-DRP1 Pathway Plays a Key Role in ox-LDL-induced Mitochondrial Fission and Endothelial Apoptosis. PMID: 35331106
Mitochondrial AKAP1 supports mTOR pathway and tumor growth. PMID: 28569781
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. PMID: 32312949
Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice. PMID: 29388469
1-Nitropyrene disrupts testosterone biogenesis via AKAP1 degradation promoted mitochondrial fission in mouse Leydig cell. PMID: 35613681
AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing. PMID: 37175819
Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure. PMID: 29892230
Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis. PMID: 27136357
Hypoxia-induced circular RNA hsa_circ_0008450 accelerates hepatocellular cancer progression via the miR-431/AKAP1 axis. PMID: 33193848
PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics. PMID: 22049414
Correction: Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis. PMID: 27384315
A-kinase anchor protein 1 (AKAP1) regulates cAMP-dependent protein kinase (PKA) localization and is involved in meiotic maturation of porcine oocytes. PMID: 23426434
A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease. PMID: 31991888
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. PMID: 29092894
Higher expression of A-kinase anchoring-protein 1 predicts poor prognosis in human hepatocellular carcinoma. PMID: 29928393
Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression. PMID: 33868472
Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. PMID: 32855239
Mitochondria-associated endoplasmic reticulum membranes promote mitochondrial fission through AKAP1-Drp1 pathway in podocytes under high glucose conditions. PMID: 36775185
NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. PMID: 10352013
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. PMID: 21526220
Characterization of RII(beta) and D-AKAP1 in differentiated adipocytes. PMID: 11742813
Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function. PMID: 24412345
Short RNA molecules with high binding affinity to the KH motif of A-kinase anchoring protein 1 (AKAP1): implications for the regulation of steroidogenesis. PMID: 23077346
Mitochondrial PKA Is Neuroprotective in a Cell Culture Model of Alzheimer's Disease. PMID: 33624140
A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury. PMID: 36263130
Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM. PMID: 32797476
Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein. PMID: 16756943
The function and mechanism of microRNA-92a-3p in lipopolysaccharide-induced acute lung injury. PMID: 34783628
Pivotal role of AKAP121 in mitochondrial physiology. PMID: 26825124
PINK1 regulates mitochondrial trafficking in dendrites of cortical neurons through mitochondrial PKA. PMID: 28556983
A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. PMID: 11994283
The BBSome regulates mitochondria dynamics and function. PMID: 36513220
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes. PMID: 34514737
The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. PMID: 19570980
Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology. PMID: 35887048
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. PMID: 9065479
The nuclear envelope, lamins and nuclear assembly. PMID: 12067659
How AMPK and PKA Interplay to Regulate Mitochondrial Function and Survival in Models of Ischemia and Diabetes. PMID: 29391924
D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane. PMID: 26950402
PKA, PKC, and AKAP localization in and around the neuromuscular junction. PMID: 11716788
Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. PMID: 26437602
Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy. PMID: 31349216
Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification. PMID: 33412331
PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations. PMID: 30772175
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study. PMID: 36274151
The effect of SiNPs on DNA methylation of genome in mouse spermatocytes. PMID: 33840017
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. PMID: 27091447
Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. PMID: 31674811
DNA Methylation and Asthma Acquisition during Adolescence and Post-Adolescence, an Epigenome-Wide Longitudinal Study. PMID: 35207690
PKA-type I selective constrained peptide disruptors of AKAP complexes. PMID: 25765284
Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. PMID: 32144179
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations. PMID: 29895819
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface. PMID: 32482893
Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping. PMID: 9857038
[Progress in researches on A-kinase anchor proteins in sperm]. PMID: 15497715
Probing of protein localization and shuttling in mitochondrial microcompartments by FLIM with sub-diffraction resolution. PMID: 27016377
Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress. PMID: 30652267
Characterization of A-kinase-anchoring disruptors using a solution-based assay. PMID: 16948636
Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89. PMID: 21689781
AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. PMID: 18786546
Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility. PMID: 30598507
Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. PMID: 19667072
Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. PMID: 19074462
MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression. PMID: 28965855
Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera. PMID: 26748308
Multi-stage screening cell-free seminal mRNAs to diagnose completion of meiosis and predict testicular sperm retrieval in men with non-obstructive azoospermia. PMID: 35266640
The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy. PMID: 19358331
Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism. PMID: 16251349
Developmentally acquired PKA localisation in mouse oocytes and embryos. PMID: 18367160
Dynamic anchoring of PKA is essential during oocyte maturation. PMID: 16461287
Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. PMID: 18323779
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. PMID: 22099302
Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility. PMID: 22310664
AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress. PMID: 20511238
PKA-dependent binding of mRNA to the mitochondrial AKAP121 protein. PMID: 12654270
Hepatic AKAP1 deficiency exacerbates diet-induced MASLD by enhancing GPAT1-mediated lysophosphatidic acid synthesis., PMID:40341440
A-kinase anchoring protein 1: an independent predictor of coronary artery disease., PMID:40055597
A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation., PMID:39986592
AKAP1-STABILIZED TIMP-4 ATTENUATES ANG-II-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN VASCULAR SMOOTH MUSCLE CELLS BY INACTIVATING THE NF-ΚB SIGNALING., PMID:39965635
Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)., PMID:39878941
LINC00323 knockdown suppresses the proliferation, migration, and vascular mimicry of non-small cell lung cancer cells by promoting ubiquitinated degradation of AKAP1., PMID:39802612
Genetic architecture of RNA editing, splicing and gene expression in schizophrenia., PMID:39656777
Insights into the regulation of mRNA translation by scaffolding proteins., PMID:39641595
AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis., PMID:39537840
Ibrutinib Promotes Atrial Fibrillation by Disrupting A-Kinase Anchoring Protein 1-Mediated Mitochondrial Quality Surveillance in Cardiomyocytes., PMID:39469220
miR-199a-5p aggravates renal ischemia-reperfusion and transplant injury by targeting AKAP1 to disrupt mitochondrial dynamics., PMID:39265082
Stable long-term germline transmission of GFP transgenic rat via PiggyBac transposon mediated gene transfer., PMID:38918814
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes., PMID:38909044
AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission., PMID:38850669
lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation., PMID:38745296
Driving Mitochondrial Fission Improves Cognitive, but not Motor Deficits in a Mouse Model of Ataxia of Charlevoix-Saguenay., PMID:38735882
Driving mitochondrial fission improves cognitive, but not motor deficits in a mouse model of Ataxia of Charlevoix-Saguenay., PMID:38659734
AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte., PMID:38286648
Ligustilide-loaded liposome ameliorates mitochondrial impairments and improves cognitive function via the PKA/AKAP1 signaling pathway in a mouse model of Alzheimer's disease., PMID:37718506
[Protective effect and mechanism of AKAP1 on myocardial injury induced by highland hypobaric hypoxia]., PMID:37524671
Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection., PMID:37296658
Mitochondria-associated endoplasmic reticulum membranes promote mitochondrial fission through AKAP1-Drp1 pathway in podocytes under high glucose conditions., PMID:36775185
The BBSome regulates mitochondria dynamics and function., PMID:36513220
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study., PMID:36274151
A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury., PMID:36263130
Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology., PMID:35887048
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease., PMID:35844803
1-Nitropyrene disrupts testosterone biogenesis via AKAP1 degradation promoted mitochondrial fission in mouse Leydig cell., PMID:35613681
Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia., PMID:35370705
miR-199b-5p-AKAP1-DRP1 Pathway Plays a Key Role in ox-LDL-induced Mitochondrial Fission and Endothelial Apoptosis., PMID:35331106
Multi-stage screening cell-free seminal mRNAs to diagnose completion of meiosis and predict testicular sperm retrieval in men with non-obstructive azoospermia., PMID:35266640
The function and mechanism of microRNA-92a-3p in lipopolysaccharide-induced acute lung injury., PMID:34783628
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes., PMID:34514737
Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression., PMID:33868472
AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes., PMID:33747723
Mitochondrial PKA Is Neuroprotective in a Cell Culture Model of Alzheimer's Disease., PMID:33624140
Deleterious variants in genes regulating mammalian reproduction in Neanderthals, Denisovans and extant humans., PMID:33417716
Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification., PMID:33412331
Hypoxia-induced circular RNA hsa_circ_0008450 accelerates hepatocellular cancer progression via the miR-431/AKAP1 axis., PMID:33193848
Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation., PMID:32855239
Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM., PMID:32797476
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface., PMID:32482893
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells., PMID:32312949
Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia., PMID:32144179
AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes., PMID:32108342
Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis., PMID:32072193
A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease., PMID:31991888
A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases., PMID:31783032
Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα., PMID:31674811
Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy., PMID:31349216