Interstitial Lung Disease in Anti-MDA5 Positive Dermatomyositis. PMID: 33405101
Dermatomyositis With Anti-MDA5 Antibodies: Bioclinical Features, Pathogenesis and Emerging Therapies. PMID: 34745149
Anti-MDA5-associated dermatomyositis. PMID: 32270621
Anti-MDA5 dermatomyositis after COVID-19 vaccination: a case-based review. PMID: 35661906
Anti-MDA5 dermatomyositis: an update from bench to bedside. PMID: 36094462
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications. PMID: 36309526
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. PMID: 16625202
Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features. PMID: 29229575
The intersection molecule MDA5 in Cancer and COVID-19. PMID: 36119095
Editorial: Anti-MDA5-Positive Dermatomyositis. PMID: 35712109
MDA5-filament, dynamics and disease. PMID: 25676875
Roles of biomarkers in anti-MDA5-positive dermatomyositis, associated interstitial lung disease, and rapidly progressive interstitial lung disease. PMID: 36221983
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5. PMID: 31379819
Dermatomyositis: Clinical features and pathogenesis. PMID: 31279808
Anti-MDA5 Antibody Spectrum in Western World. PMID: 30382445
Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. PMID: 29395326
MDA5 autoantibody-another indicator of clinical diversity in dermatomyositis. PMID: 28480196
Different Multivariable Risk Factors for Rapid Progressive Interstitial Lung Disease in Anti-MDA5 Positive Dermatomyositis and Anti-Synthetase Syndrome. PMID: 35320936
A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation. PMID: 30201512
A New Predictive Model for the Prognosis of MDA5+ DM-ILD. PMID: 35783655
[Dermatomyositis with anti-MDA5 antibodies]. PMID: 31626458
MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations. PMID: 26557046
Presence of Anti-MDA5 Antibody and Its Value for the Clinical Assessment in Patients With COVID-19: A Retrospective Cohort Study. PMID: 34987516
To "Z" or not to "Z": Z-RNA, self-recognition, and the MDA5 helicase. PMID: 33983939
MDA5 attenuate autophagy in chicken embryo fibroblasts infected with IBDV. PMID: 34406094
Prognostic values of anti-Ro52 antibodies in anti-MDA5-positive clinically amyopathic dermatomyositis associated with interstitial lung disease. PMID: 33331866
MDA5 expression is associated with TGF-β-induced fibrosis: potential mechanism of interstitial lung disease in anti-MDA5 dermatomyositis. PMID: 35412608
Monoclonal antibodies from B cells of patients with anti-MDA5 antibody-positive dermatomyositis directly stimulate interferon gamma production. PMID: 35436746
Anti-MDA5 Amyopathic Dermatomyositis-A Diagnostic and Therapeutic Challenge. PMID: 35892910
Cardiac involvement in anti-MDA5 dermatomyositis: a case-based review. PMID: 36454342
Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development. PMID: 32635205
Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective. PMID: 34834938
LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling. PMID: 25794939
Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review. PMID: 31080451
Melanoma differentiation-Associated gene 5 protects against NASH in mice. PMID: 34482560
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. PMID: 34795277
Recurrence in long-term survivor of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis: case series and literature review. PMID: 33560195
Clinical Features of Dermatomyositis/Polymyositis with Anti-MDA5 Antibody Positivity. PMID: 35992549
RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5'-UTR. PMID: 35414110
MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. PMID: 36512407
IFIH1 Contributes to M1 Macrophage Polarization in ARDS. PMID: 33519803
Genetic and phenotypic spectrum associated with IFIH1 gain-of-function. PMID: 31898846
IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease. PMID: 34185153
[Dermatomyositis: new antibody, new classification]. PMID: 31859626
Tofacitinib in Amyopathic Dermatomyositis-Associated Interstitial Lung Disease. PMID: 31314977
Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression. PMID: 26385483
Immunogenicity of In Vitro-Transcribed RNA. PMID: 34677064
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown. PMID: 29395325
The Significance of Autoantibodies in Juvenile Dermatomyositis. PMID: 34840975
Biomarkers of disease activity in dermatomyositis. PMID: 36082751
Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis. PMID: 23734776
Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population. PMID: 35983127
Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review. PMID: 20121398
Hereditary spastic paraplegia associated with a rare IFIH1 mutation: a case report and literature review. PMID: 31427910
Polymorphisms in IFIH1: the good and the bad. PMID: 28632717
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19. PMID: 36672770
Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond. PMID: 27643693
Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study. PMID: 35060899
The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus. PMID: 24402011
ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation. PMID: 34380029
IFIH1/IRF1/STAT1 promotes sepsis associated inflammatory lung injury via activating macrophage M1 polarization. PMID: 36462334
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. PMID: 33727702
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. PMID: 33373584
Severe viral respiratory infections in children with IFIH1 loss-of-function mutations. PMID: 28716935
IFIH1 was predicted as a key biomarker in primary Sjögren's syndrome based on transcriptome analysis and experimental verification in patients and mice. PMID: 36973184
Reduced expression of IFIH1 is protective for type 1 diabetes. PMID: 20844740
Rituximab in the Treatment of Interstitial Lung Diseases Related to Anti-Melanoma Differentiation-Associated Gene 5 Dermatomyositis: A Systematic Review. PMID: 35116041
An origin of the immunogenicity of in vitro transcribed RNA. PMID: 29534222
Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection. PMID: 32574256
ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. PMID: 36000401
Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes. PMID: 32974248
Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility. PMID: 23535865
IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages. PMID: 36380629
A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome. PMID: 25620204
USP8-Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity., PMID:40525588
Immunohistochemical Profiling of Interferon-Stimulated Genes in Histopathological Specimens: A Potential Screening Approach for Viral Infections., PMID:40518873
Anti-melanoma differentiation-associated gene 5 antibody associated rapidly progressive interstitial lung disease in a pediatric patient: a case report., PMID:40514742
The macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses., PMID:40493408
Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer., PMID:40492347
Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation., PMID:40483467
Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice., PMID:40463036
MDA5 variants trade antiviral activity for protection from autoimmune disease., PMID:40457382
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5., PMID:40454785
Potential of Circular RNAs (circRNAs) Neoantigen Vaccines in Tumor Immunotherapy., PMID:40442904
The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion., PMID:40431746
Anti-MDA5 antibody positive dermatomyositis complicated by interstitial lung disease with an improved outcome: A case report., PMID:40419927
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion., PMID:40413207
The viral early protein 4 of human papillomavirus type 16 suppresses innate antiviral immunity., PMID:40409624
Identification of pattern recognition receptors participating in the innate immune response to Tembusu virus., PMID:40374862
Shared and Distinctive Inflammation-Related Protein Profiling in Idiopathic Inflammatory Myopathy with/without Anti-MDA5 Autoantibodies., PMID:40357378
cGAS/STING-Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B., PMID:40353728
The C-terminal nsP1a protein of porcine astrovirus antagonizes interferon beta production by targets MAVS and IRF3 signaling., PMID:40339257
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response., PMID:40330464
Anti- Melanoma Differentiation-Associated Gene 5 Antibody Positive Dermatomyositis: Recent Progress in Pathophysiology and Treatment., PMID:40323493
CD19 CAR-T cell therapy in a pediatric patient with MDA5+ dermatomyositis and rapidly progressive interstitial lung disease., PMID:40306284
Accessory viral protein, V, of Newcastle Disease Virus binds dsRNA to facilitate immune evasion., PMID:40290766
Cepharanthine mitigates NIBV-induced pyroptosis via the MDA5/NF-κB/NLRP3 signaling pathway., PMID:40273551
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways., PMID:40264759
Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy., PMID:40253768
SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases., PMID:40253699
Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis., PMID:40250126
Oxidation of human mitochondrial RNA strongly potentiates immunostimulation in an interferon-associated manner., PMID:40247667
Analysis of the immune response in COVID-19., PMID:40246347
Severe infection risk in triple and quadruple therapy for anti-MDA5 antibody-positive dermatomyositis., PMID:40244469
Identifying two pathways to poor prognosis in patients with anti-MDA5 antibodies: insights from prognostic factor and cytokines analysis., PMID:40241163
METTL3 depletion blocks vesicular stomatitis virus replication in pancreatic cancer cells through the establishment of an intrinsic antiviral state., PMID:40214229
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor., PMID:40205031
ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication., PMID:40198737
N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling., PMID:40198675
ATPase activity profiling of three human DExD/H-box RNA helicases., PMID:40194700
MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis., PMID:40184173
ASFV pS183L protein negatively regulates RLR-mediated antiviral signalling by blocking MDA5 oligomerisation., PMID:40165208
Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma., PMID:40135601
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis., PMID:40122798
LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes., PMID:40121229
Nailfold videocapillaroscopy findings are associated with IIM subtypes and IFN activation., PMID:40114239
Amyopathic dermatomyositis associated with immune checkpoint inhibitor therapy in lung adenocarcinoma: a case report., PMID:40104725
Overexpression of LMOD1 induces oxidative stress and enhances cell apoptosis of melanoma through the RIG-I like receptor pathway., PMID:40068386
External validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China., PMID:40056481
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity., PMID:40055821
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein., PMID:40006954
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer., PMID:40000433
The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses., PMID:39998221
For research use only. Not for human or drug use.
